Peringatan Keamanan

It is hazardous in case of ingestion MSDS. The carcinogenicity, mutagenicity and effects on reproductive fertility of trolamine salicylate have not been reported.

Trolamine salicylate

DB11079

small molecule approved

Deskripsi

Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike other topical analgesics, trolamine salicylate has no distinct odor which improves patient acceptability A32189. It also displays low systemic absorption upon dermal or topical administration A32190 and has low skin irritant properties A32191. As with other salicylates, trolamine salicylate is an inhibitor of cyclo-oxygenase (COX) enzymes with no reported selectivity towards a specific enzyme isoform. Trolamine salicylate serves as an active ingredient in topical over-the-counter products for temporary management of mild to moderate muscular and joint pains.

Struktur Molekul 2D

Berat 287.312
Wujud -

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi Topical administration of 1 gram of 10% trolamine salicylate in abdominal rat skin resulted in an approximate extravascular volume of distribution (V/F) of 24.0 mL [A32191].
Klirens (Clearance) -

Absorpsi

Following topical administration of 10% trolamine salicylate in healthy volunteers, salicylic acid could not be detected in serum indicating low systemic absorption A32190.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Following topical administration of 10% trolamine salicylate in healthy volunteers, urinary recovery of total salicylate during the first 24 hours was 6.9 mg (p < 0.05), which is 1.4% of total dose A32190.

Interaksi Obat

343 Data
Coumarin Trolamine salicylate may increase the anticoagulant activities of Coumarin.
Lepirudin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Lepirudin.
Bivalirudin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Bivalirudin.
Alteplase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Alteplase.
Urokinase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Urokinase.
Reteplase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Reteplase.
Anistreplase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Anistreplase.
Tenecteplase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Tenecteplase.
Abciximab The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Abciximab.
Drotrecogin alfa The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Drotrecogin alfa.
Streptokinase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Streptokinase.
Dicoumarol Trolamine salicylate may increase the anticoagulant activities of Dicoumarol.
Argatroban The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Argatroban.
Ardeparin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Ardeparin.
Phenindione Trolamine salicylate may increase the anticoagulant activities of Phenindione.
Fondaparinux The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Fondaparinux.
Warfarin Trolamine salicylate may increase the anticoagulant activities of Warfarin.
Pentosan polysulfate The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Pentosan polysulfate.
Phenprocoumon Trolamine salicylate may increase the anticoagulant activities of Phenprocoumon.
Dipyridamole The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Dipyridamole.
Heparin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Heparin.
Enoxaparin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Enoxaparin.
Epoprostenol The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Epoprostenol.
Acenocoumarol Trolamine salicylate may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Trolamine salicylate may increase the anticoagulant activities of 4-hydroxycoumarin.
Ximelagatran The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Ximelagatran.
Desmoteplase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Desmoteplase.
Defibrotide The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Defibrotide.
Ancrod The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Ancrod.
Beraprost The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Beraprost.
Prasugrel The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Prasugrel.
Rivaroxaban The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Rivaroxaban.
Sulodexide The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Sulodexide.
Semuloparin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Semuloparin.
Idraparinux The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Idraparinux.
Cangrelor The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Cangrelor.
Astaxanthin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Astaxanthin.
Apixaban The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Apixaban.
Otamixaban The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Otamixaban.
Amediplase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Amediplase.
Dabigatran etexilate The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Dabigatran etexilate.
Danaparoid The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Danaparoid.
Dalteparin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Dalteparin.
Tinzaparin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Tinzaparin.
(R)-warfarin Trolamine salicylate may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Trolamine salicylate may increase the anticoagulant activities of Ethyl biscoumacetate.
Nadroparin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Nadroparin.
Triflusal The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Triflusal.
Ticagrelor The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Ticagrelor.
Ditazole The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Ditazole.
Vorapaxar The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Vorapaxar.
Edoxaban The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Edoxaban.
Sodium citrate The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Sodium citrate.
Dextran The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Dextran.
Bemiparin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Bemiparin.
Parnaparin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Parnaparin.
Desirudin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Desirudin.
Antithrombin Alfa The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Antithrombin Alfa.
Protein C The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Protein C.
Antithrombin III human The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Antithrombin III human.
Letaxaban The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Letaxaban.
Darexaban The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Darexaban.
Betrixaban The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Betrixaban.
Nafamostat The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Nafamostat.
Monteplase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Monteplase.
Gabexate The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Gabexate.
Fluindione Trolamine salicylate may increase the anticoagulant activities of Fluindione.
Protein S human The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Protein S human.
Brinase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Brinase.
Clorindione Trolamine salicylate may increase the anticoagulant activities of Clorindione.
Diphenadione Trolamine salicylate may increase the anticoagulant activities of Diphenadione.
Tioclomarol Trolamine salicylate may increase the anticoagulant activities of Tioclomarol.
Melagatran The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Melagatran.
Saruplase The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Saruplase.
(S)-Warfarin Trolamine salicylate may increase the anticoagulant activities of (S)-Warfarin.
Tocopherylquinone The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Tocopherylquinone.
Dabigatran The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Dabigatran.
Troxerutin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Troxerutin.
Edetic acid The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Edetic acid.
Reviparin The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Reviparin.
Dermatan sulfate The risk or severity of bleeding can be increased when Trolamine salicylate is combined with Dermatan sulfate.
SR-123781A The risk or severity of bleeding can be increased when Trolamine salicylate is combined with SR-123781A.
Insulin human The risk or severity of hypoglycemia can be increased when Trolamine salicylate is combined with Insulin human.
Insulin lispro The risk or severity of hypoglycemia can be increased when Trolamine salicylate is combined with Insulin lispro.
Insulin glargine The risk or severity of hypoglycemia can be increased when Trolamine salicylate is combined with Insulin glargine.
Insulin pork The risk or severity of hypoglycemia can be increased when Trolamine salicylate is combined with Insulin pork.
Troglitazone Trolamine salicylate may increase the hypoglycemic activities of Troglitazone.
Glimepiride Trolamine salicylate may increase the hypoglycemic activities of Glimepiride.
Sulfisoxazole Trolamine salicylate may increase the hypoglycemic activities of Sulfisoxazole.
Disopyramide Trolamine salicylate may increase the hypoglycemic activities of Disopyramide.
Acarbose Trolamine salicylate may increase the hypoglycemic activities of Acarbose.
Metformin Trolamine salicylate may increase the hypoglycemic activities of Metformin.
Sulfadiazine Trolamine salicylate may increase the hypoglycemic activities of Sulfadiazine.
Rosiglitazone Trolamine salicylate may increase the hypoglycemic activities of Rosiglitazone.
Acetohexamide Trolamine salicylate may increase the hypoglycemic activities of Acetohexamide.
Quinine Trolamine salicylate may increase the hypoglycemic activities of Quinine.
Miglitol Trolamine salicylate may increase the hypoglycemic activities of Miglitol.
Chlorpropamide Trolamine salicylate may increase the hypoglycemic activities of Chlorpropamide.
Nateglinide Trolamine salicylate may increase the hypoglycemic activities of Nateglinide.
Pentamidine Trolamine salicylate may increase the hypoglycemic activities of Pentamidine.

Target Protein

Prostaglandin G/H synthase 1 PTGS1
Prostaglandin G/H synthase 2 PTGS2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 19078236
    Rothacker DQ, Lee I, Littlejohn TW 3rd: Effectiveness of a single topical application of 10|x% trolamine salicylate cream in the symptomatic treatment of osteoarthritis. J Clin Rheumatol. 1998 Feb;4(1):6-12.
  • PMID: 18796932
    Hill DW, Richardson JD: Effectiveness of 10% trolamine salicylate cream on muscular soreness induced by a reproducible program of weight training. J Orthop Sports Phys Ther. 1989;11(1):19-23.
  • PMID: 8876850
    Morra P, Bartle WR, Walker SE, Lee SN, Bowles SK, Reeves RA: Serum concentrations of salicylic acid following topically applied salicylate derivatives. Ann Pharmacother. 1996 Sep;30(9):935-40. doi: 10.1177/106002809603000903.
  • PMID: 24312851
    Sajjadi P, Khodayar MJ, Sharif Makhmalzadeh B, Rezaee S: Percutaneous absorption of salicylic Acid after administration of trolamine salicylate cream in rats with transcutol((R)) and eucalyptus oil pre-treated skin. Adv Pharm Bull. 2013;3(2):295-301. doi: 10.5681/apb.2013.048. Epub 2013 Aug 20.
Textbook
  • ISBN: 978-0-7020-3471-8
    26. (2012). In Rang and Dale's Pharmacology (7th ed., pp. 318-322). Edinburgh: Elsevier/Churchill Livingstone.

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