Peringatan Keamanan

Injectable selenium is more acutely toxic than oral administration, with an intramuscular LD50 of 0.5 mg/kg BW in lambs ^A33009.

Selenic acid

DB11068

small molecule approved

Deskripsi

Selenic acid is an organic compound with the chemical formula H2SeO4. It may be found in over-the-counter daily dietary supplements as a source of DB11135, an essential trace mineral for human health.

Struktur Molekul 2D

Berat 144.97

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Following single oral administration of 1 mg Se/kg of sodium selenate in lambs, the elimination half life was 313 hours. The elimination half life was 142 hours following a single oral dosing of 4 mg Se/kg as sodium selenate [A33009].

Volume Distribusi No pharmacokinetic data available.

Klirens (Clearance) No pharmacokinetic data available.

Absorpsi

Following single oral administration of sodium selenate concentrations ranging from 1 mg Se/kg to 4 mg Se/kg in lambs, the peak plasma concentrations ranged from 0.79 mg Se/L to 2.54 mg Se/L ^A33009. The time to reach peak plasma concentrations ranged from 7 to 12 hours ^A33009.

Metabolisme

No pharmacokinetic data available.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1 Data

Eltrombopag

The bioavailability of Selenic acid can be decreased when combined with Eltrombopag.

Referensi & Sumber

Artikel (PubMed)

PMID: 22381456
Rayman MP: Selenium and human health. Lancet. 2012 Mar 31;379(9822):1256-68. doi: 10.1016/S0140-6736(11)61452-9. Epub 2012 Feb 29.
PMID: 10963212
Rayman MP: The importance of selenium to human health. Lancet. 2000 Jul 15;356(9225):233-41. doi: 10.1016/S0140-6736(00)02490-9.
PMID: 23825349
Davis TZ, Stegelmeier BL, Welch KD, Pfister JA, Panter KE, Hall JO: Comparative oral dose toxicokinetics of selenium compounds commonly found in selenium accumulator plants. J Anim Sci. 2013 Sep;91(9):4501-9. doi: 10.2527/jas.2012-6101. Epub 2013 Jul 3.

Contoh Produk & Brand

Produk: 29 • International brands: 0

Produk

Balance Ace - Cap

Capsule • - • Oral • Canada • OTC • Approved
Beta A With Vitamins C and E Plus Selenium

Capsule • - • Oral • Canada • OTC • Approved
Cavan Heme OB

Tablet • - • Oral • US
Cell-wise Natural Source

Tablet • - • Oral • Canada • OTC • Approved
Corvita

Tablet, coated • - • Oral • US
Duet DHA Balanced

Capsule, gelatin coated; Kit; Tablet • - • Oral • US
HemeNatal OB

Tablet • - • Oral • US
HemeNatal OB plus DHA

Kit • - • Oral • US

Menampilkan 8 dari 29 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.