Peringatan Keamanan

The adverse reactions from azficel-T treatment tend to be limited to injection site reactions FDA Label.

Azficel-T

DB11051

biotech approved investigational

Deskripsi

Azficel-T is an autologous cellular product composed of fibroblasts indicated for improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults. Dermal fibroblasts are collected from the post-auricular biopsy tissue and aseptically expanded using standard tissue-culture procedures until sufficient cells for three doses are obtained FDA Label. Expanded cells are then suspended in a cell medium. As a replacement for lost dermal constituents in the aging or skin deformation process, treatment with autologous fibroblasts has shown to improve wrinkle and acne scar appearance than with placebo treatment A31920, A31926. Intradermal administration of autologous dermal fibroblasts into irradiated skin following surgical procedures was associated with an improved healing process of subsequent surgical wounds A31927. Azficel-T is marketed in the US as Laviv for intradermal injection.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

187 Data
Icosapent The risk or severity of adverse effects can be increased when Icosapent is combined with Azficel-T.
Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Azficel-T.
Nabumetone The risk or severity of adverse effects can be increased when Nabumetone is combined with Azficel-T.
Ketorolac The risk or severity of adverse effects can be increased when Ketorolac is combined with Azficel-T.
Tenoxicam The risk or severity of adverse effects can be increased when Tenoxicam is combined with Azficel-T.
Celecoxib The risk or severity of adverse effects can be increased when Celecoxib is combined with Azficel-T.
Tolmetin The risk or severity of adverse effects can be increased when Tolmetin is combined with Azficel-T.
Rofecoxib The risk or severity of adverse effects can be increased when Rofecoxib is combined with Azficel-T.
Piroxicam The risk or severity of adverse effects can be increased when Piroxicam is combined with Azficel-T.
Fenoprofen The risk or severity of adverse effects can be increased when Fenoprofen is combined with Azficel-T.
Valdecoxib The risk or severity of adverse effects can be increased when Valdecoxib is combined with Azficel-T.
Diclofenac The risk or severity of adverse effects can be increased when Diclofenac is combined with Azficel-T.
Sulindac The risk or severity of adverse effects can be increased when Sulindac is combined with Azficel-T.
Flurbiprofen The risk or severity of adverse effects can be increased when Flurbiprofen is combined with Azficel-T.
Etodolac The risk or severity of adverse effects can be increased when Etodolac is combined with Azficel-T.
Mefenamic acid The risk or severity of adverse effects can be increased when Mefenamic acid is combined with Azficel-T.
Naproxen The risk or severity of adverse effects can be increased when Naproxen is combined with Azficel-T.
Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Azficel-T.
Phenylbutazone The risk or severity of adverse effects can be increased when Phenylbutazone is combined with Azficel-T.
Meloxicam The risk or severity of adverse effects can be increased when Meloxicam is combined with Azficel-T.
Carprofen The risk or severity of adverse effects can be increased when Carprofen is combined with Azficel-T.
Diflunisal The risk or severity of adverse effects can be increased when Diflunisal is combined with Azficel-T.
Salicylic acid The risk or severity of adverse effects can be increased when Salicylic acid is combined with Azficel-T.
Meclofenamic acid The risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Azficel-T.
Acetylsalicylic acid The risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Azficel-T.
Oxaprozin The risk or severity of adverse effects can be increased when Oxaprozin is combined with Azficel-T.
Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Azficel-T.
Balsalazide The risk or severity of adverse effects can be increased when Balsalazide is combined with Azficel-T.
Ibuprofen The risk or severity of adverse effects can be increased when Ibuprofen is combined with Azficel-T.
Lumiracoxib The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Azficel-T.
Magnesium salicylate The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Azficel-T.
Salsalate The risk or severity of adverse effects can be increased when Salsalate is combined with Azficel-T.
Choline magnesium trisalicylate The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Azficel-T.
Antrafenine The risk or severity of adverse effects can be increased when Antrafenine is combined with Azficel-T.
Aminophenazone The risk or severity of adverse effects can be increased when Aminophenazone is combined with Azficel-T.
Antipyrine The risk or severity of adverse effects can be increased when Antipyrine is combined with Azficel-T.
Tiaprofenic acid The risk or severity of adverse effects can be increased when Tiaprofenic acid is combined with Azficel-T.
Etoricoxib The risk or severity of adverse effects can be increased when Etoricoxib is combined with Azficel-T.
Taxifolin The risk or severity of adverse effects can be increased when Taxifolin is combined with Azficel-T.
Oxyphenbutazone The risk or severity of adverse effects can be increased when Oxyphenbutazone is combined with Azficel-T.
Licofelone The risk or severity of adverse effects can be increased when Licofelone is combined with Azficel-T.
Nimesulide The risk or severity of adverse effects can be increased when Nimesulide is combined with Azficel-T.
Benoxaprofen The risk or severity of adverse effects can be increased when Benoxaprofen is combined with Azficel-T.
Zomepirac The risk or severity of adverse effects can be increased when Zomepirac is combined with Azficel-T.
Cimicoxib The risk or severity of adverse effects can be increased when Cimicoxib is combined with Azficel-T.
Lornoxicam The risk or severity of adverse effects can be increased when Lornoxicam is combined with Azficel-T.
Aceclofenac The risk or severity of adverse effects can be increased when Aceclofenac is combined with Azficel-T.
Zaltoprofen The risk or severity of adverse effects can be increased when Zaltoprofen is combined with Azficel-T.
Azapropazone The risk or severity of adverse effects can be increased when Azapropazone is combined with Azficel-T.
Parecoxib The risk or severity of adverse effects can be increased when Parecoxib is combined with Azficel-T.
Salicylamide The risk or severity of adverse effects can be increased when Salicylamide is combined with Azficel-T.
Kebuzone The risk or severity of adverse effects can be increased when Kebuzone is combined with Azficel-T.
Isoxicam The risk or severity of adverse effects can be increased when Isoxicam is combined with Azficel-T.
Indoprofen The risk or severity of adverse effects can be increased when Indoprofen is combined with Azficel-T.
Ibuproxam The risk or severity of adverse effects can be increased when Ibuproxam is combined with Azficel-T.
Floctafenine The risk or severity of adverse effects can be increased when Floctafenine is combined with Azficel-T.
Fenbufen The risk or severity of adverse effects can be increased when Fenbufen is combined with Azficel-T.
Etofenamate The risk or severity of adverse effects can be increased when Etofenamate is combined with Azficel-T.
Epirizole The risk or severity of adverse effects can be increased when Epirizole is combined with Azficel-T.
Benzydamine The risk or severity of adverse effects can be increased when Benzydamine is combined with Azficel-T.
Dexibuprofen The risk or severity of adverse effects can be increased when Dexibuprofen is combined with Azficel-T.
Dexketoprofen The risk or severity of adverse effects can be increased when Dexketoprofen is combined with Azficel-T.
Droxicam The risk or severity of adverse effects can be increased when Droxicam is combined with Azficel-T.
Tolfenamic acid The risk or severity of adverse effects can be increased when Tolfenamic acid is combined with Azficel-T.
Firocoxib The risk or severity of adverse effects can be increased when Firocoxib is combined with Azficel-T.
Clonixin The risk or severity of adverse effects can be increased when Clonixin is combined with Azficel-T.
Morniflumate The risk or severity of adverse effects can be increased when Morniflumate is combined with Azficel-T.
Propacetamol The risk or severity of adverse effects can be increased when Propacetamol is combined with Azficel-T.
Talniflumate The risk or severity of adverse effects can be increased when Talniflumate is combined with Azficel-T.
Robenacoxib The risk or severity of adverse effects can be increased when Robenacoxib is combined with Azficel-T.
Tepoxalin The risk or severity of adverse effects can be increased when Tepoxalin is combined with Azficel-T.
Flunixin The risk or severity of adverse effects can be increased when Flunixin is combined with Azficel-T.
Polmacoxib The risk or severity of adverse effects can be increased when Polmacoxib is combined with Azficel-T.
Nitroaspirin The risk or severity of adverse effects can be increased when Nitroaspirin is combined with Azficel-T.
Indobufen The risk or severity of adverse effects can be increased when Indobufen is combined with Azficel-T.
Ebselen The risk or severity of adverse effects can be increased when Ebselen is combined with Azficel-T.
Tinoridine The risk or severity of adverse effects can be increased when Tinoridine is combined with Azficel-T.
Alclofenac The risk or severity of adverse effects can be increased when Alclofenac is combined with Azficel-T.
Fentiazac The risk or severity of adverse effects can be increased when Fentiazac is combined with Azficel-T.
Suxibuzone The risk or severity of adverse effects can be increased when Suxibuzone is combined with Azficel-T.
Bumadizone The risk or severity of adverse effects can be increased when Bumadizone is combined with Azficel-T.
Alminoprofen The risk or severity of adverse effects can be increased when Alminoprofen is combined with Azficel-T.
Difenpiramide The risk or severity of adverse effects can be increased when Difenpiramide is combined with Azficel-T.
Nifenazone The risk or severity of adverse effects can be increased when Nifenazone is combined with Azficel-T.
Lonazolac The risk or severity of adverse effects can be increased when Lonazolac is combined with Azficel-T.
Tenidap The risk or severity of adverse effects can be increased when Tenidap is combined with Azficel-T.
Propyphenazone The risk or severity of adverse effects can be increased when Propyphenazone is combined with Azficel-T.
Proglumetacin The risk or severity of adverse effects can be increased when Proglumetacin is combined with Azficel-T.
Guacetisal The risk or severity of adverse effects can be increased when Guacetisal is combined with Azficel-T.
Ethenzamide The risk or severity of adverse effects can be increased when Ethenzamide is combined with Azficel-T.
Carbaspirin calcium The risk or severity of adverse effects can be increased when Carbaspirin calcium is combined with Azficel-T.
Mofebutazone The risk or severity of adverse effects can be increased when Mofebutazone is combined with Azficel-T.
Proquazone The risk or severity of adverse effects can be increased when Proquazone is combined with Azficel-T.
Benorilate The risk or severity of adverse effects can be increased when Benorilate is combined with Azficel-T.
Pirprofen The risk or severity of adverse effects can be increased when Pirprofen is combined with Azficel-T.
Acemetacin The risk or severity of adverse effects can be increased when Acemetacin is combined with Azficel-T.
Imidazole salicylate The risk or severity of adverse effects can be increased when Imidazole salicylate is combined with Azficel-T.
SC-236 The risk or severity of adverse effects can be increased when SC-236 is combined with Azficel-T.
NS-398 The risk or severity of adverse effects can be increased when NS-398 is combined with Azficel-T.
Flurbiprofen axetil The risk or severity of adverse effects can be increased when Flurbiprofen axetil is combined with Azficel-T.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 22409385
    Smith SR, Munavalli G, Weiss R, Maslowski JM, Hennegan KP, Novak JM: A multicenter, double-blind, placebo-controlled trial of autologous fibroblast therapy for the treatment of nasolabial fold wrinkles. Dermatol Surg. 2012 Jul;38(7 Pt 2):1234-43. doi: 10.1111/j.1524-4725.2012.02349.x. Epub 2012 Mar 12.
  • PMID: 23566237
    Munavalli GS, Smith S, Maslowski JM, Weiss RA: Successful treatment of depressed, distensible acne scars using autologous fibroblasts: a multi-site, prospective, double blind, placebo-controlled clinical trial. Dermatol Surg. 2013 Aug;39(8):1226-36. doi: 10.1111/dsu.12204. Epub 2013 Apr 8.
  • PMID: 18490597
    Fisher GJ, Varani J, Voorhees JJ: Looking older: fibroblast collapse and therapeutic implications. Arch Dermatol. 2008 May;144(5):666-72. doi: 10.1001/archderm.144.5.666.
  • PMID: 22092878
    Eca LP, Pinto DG, de Pinho AM, Mazzetti MP, Odo ME: Autologous fibroblast culture in the repair of aging skin. Dermatol Surg. 2012 Feb;38(2):180-4. doi: 10.1111/j.1524-4725.2011.02192.x. Epub 2011 Oct 10.
  • PMID: 10423337
    Ferguson PC, Boynton EL, Wunder JS, Hill RP, O'Sullivan B, Sandhu JS, Bell RS: Intradermal injection of autologous dermal fibroblasts improves wound healing in irradiated skin. J Surg Res. 1999 Aug;85(2):331-8. doi: 10.1006/jsre.1999.5664.
  • PMID: 21526076
    Nilforoushzadeh MA, Siadat AH, Arianrad M, Moulavi F, Baradaran EH, Esfahani MH: Soft tissue augmentation by autologous cultured fibroblasts transplantation for treatment of wrinkles and scars: a case series of 20 patients. J Res Med Sci. 2010 May;15(3):167-71.

Contoh Produk & Brand

Produk: 1 • International brands: 0
Produk
  • Laviv
    Injection, suspension • 15000000 1/1mL • Intradermal • US • Approved

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