There are no adequate and well-controlled studies of CYFENDUS in pregnant individuals. Available human data on CYFENDUS administered to pregnant individuals do not establish the presence or absence of vaccine-associated risks in pregnancy. However,
available data on BioThrax (a licensed anthrax vaccine), administered to pregnant individuals are relevant to CYFENDUS because BioThrax and CYFENDUS contain the same active ingredient and are manufactured similarly. BioThrax does not contain CPG 7909 adjuvant. Data are available from a BioThrax observational study and pregnancy exposure registry.L47526
In the observational study, there were more birth defects in infants born to individuals vaccinated with BioThrax in the first trimester compared to individuals vaccinated post-pregnancy or individuals never vaccinated with BioThrax. Data from the BioThrax pregnancy exposure registry do not establish the presence or absence of vaccine-associated risks in pregnancy.L47526
In a developmental study with an embryo-fetal development toxicity phase, female rats were administered a full human dose (0.5 mL) of CYFENDUS twice prior to mating and once during gestation. This study revealed no evidence of harm to the fetus, changes in reproductive performance, or adverse effects on post-natal development due to the vaccine.L47526
The anthrax vaccine has not been evaluated for carcinogenicity, mutagenic potential, or male infertility in animals. Anthrax vaccine administered to female rats had no effect on fertility.L47526
Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsulated strain of Bacillus anthracis which are grown in a chemically defined protein-free medium.L47526 It is considered one of the most likely agents to be used in a biological attack.L47561
There are currently 2 anthrax vaccines approved by the FDA: BioThrax in August 15, 2016 and CYFENDUS in July 20, 2023.L47566, L47561 These vaccines are currently stored in the Strategic National Stockpile in preparation for an Anthrax terrorist attack or for pre-exposure prophylaxis of personnel going to specific arenas around the world.L47561
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Flunisolide | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Flunisolide. |
| Betamethasone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Betamethasone. |
| Triamcinolone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Triamcinolone. |
| Prednisone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Prednisone. |
| Fludrocortisone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Fludrocortisone. |
| Hydrocortisone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Hydrocortisone. |
| Prednisolone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Prednisolone. |
| Methylprednisolone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Methylprednisolone. |
| Trilostane | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Trilostane. |
| Budesonide | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Budesonide. |
| Dexamethasone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Dexamethasone. |
| Corticotropin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Corticotropin. |
| Cortisone acetate | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Cortisone acetate. |
| Paramethasone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Paramethasone. |
| Aldosterone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Aldosterone. |
| Fluprednisolone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Fluprednisolone. |
| Meprednisone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Meprednisone. |
| Melengestrol | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Melengestrol. |
| Deflazacort | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Deflazacort. |
| Cortivazol | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Cortivazol. |
| Prednylidene | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Prednylidene. |
| Cloprednol | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Cloprednol. |
| Cortisone | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Cortisone. |
| Etanercept | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Etanercept. |
| Peginterferon alfa-2a | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Peginterferon alfa-2a. |
| Interferon alfa-n1 | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Interferon alfa-n1. |
| Interferon alfa-n3 | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Interferon alfa-n3. |
| Peginterferon alfa-2b | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Peginterferon alfa-2b. |
| Anakinra | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Anakinra. |
| Interferon gamma-1b | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Interferon gamma-1b. |
| Interferon alfa-2a | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Interferon alfa-2a. |
| Aldesleukin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Aldesleukin. |
| Adalimumab | The risk or severity of adverse effects can be increased when Adalimumab is combined with Anthrax vaccine. |
| Gemtuzumab ozogamicin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Gemtuzumab ozogamicin. |
| Pegaspargase | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Pegaspargase. |
| Infliximab | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Infliximab. |
| Interferon beta-1b | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Interferon beta-1b. |
| Interferon alfacon-1 | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Interferon alfacon-1. |
| Trastuzumab | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Trastuzumab. |
| Rituximab | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Rituximab. |
| Basiliximab | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Basiliximab. |
| Muromonab | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Muromonab. |
| Ibritumomab tiuxetan | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Ibritumomab tiuxetan. |
| Tositumomab | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Tositumomab. |
| Alemtuzumab | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Alemtuzumab. |
| Cyclosporine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Cyclosporine. |
| Alefacept | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Alefacept. |
| Efalizumab | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Efalizumab. |
| Antithymocyte immunoglobulin (rabbit) | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Antithymocyte immunoglobulin (rabbit). |
| Interferon alfa-2b | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Interferon alfa-2b. |
| Natalizumab | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Natalizumab. |
| Daclizumab | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Daclizumab. |
| Phenylalanine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Phenylalanine. |
| Bortezomib | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Bortezomib. |
| Cladribine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Cladribine. |
| Carmustine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Carmustine. |
| Amsacrine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Amsacrine. |
| Bleomycin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Bleomycin. |
| Chlorambucil | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Chlorambucil. |
| Raltitrexed | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Raltitrexed. |
| Mitomycin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Mitomycin. |
| Bexarotene | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Bexarotene. |
| Vindesine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Vindesine. |
| Floxuridine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Floxuridine. |
| Indomethacin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Indomethacin. |
| Tioguanine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Tioguanine. |
| Vinorelbine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Vinorelbine. |
| Dexrazoxane | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Dexrazoxane. |
| Sorafenib | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Sorafenib. |
| Streptozocin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Streptozocin. |
| Trifluridine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Trifluridine. |
| Gemcitabine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Gemcitabine. |
| Teniposide | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Teniposide. |
| Epirubicin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Epirubicin. |
| Chloramphenicol | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Chloramphenicol. |
| Lenalidomide | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Lenalidomide. |
| Altretamine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Altretamine. |
| Zidovudine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Zidovudine. |
| Cisplatin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Cisplatin. |
| Oxaliplatin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Oxaliplatin. |
| Cyclophosphamide | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Cyclophosphamide. |
| Vincristine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Vincristine. |
| Fluorouracil | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Fluorouracil. |
| Propylthiouracil | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Propylthiouracil. |
| Pentostatin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Pentostatin. |
| Methotrexate | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Methotrexate. |
| Carbamazepine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Carbamazepine. |
| Vinblastine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Vinblastine. |
| Linezolid | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Linezolid. |
| Imatinib | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Imatinib. |
| Clofarabine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Clofarabine. |
| Pemetrexed | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Pemetrexed. |
| Mycophenolate mofetil | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Mycophenolate mofetil. |
| Daunorubicin | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Daunorubicin. |
| Irinotecan | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Irinotecan. |
| Methimazole | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Methimazole. |
| Etoposide | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Etoposide. |
| Sulfasalazine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Sulfasalazine. |
| Dacarbazine | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Dacarbazine. |
| Temozolomide | The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Temozolomide. |