Dermatophagoides farinae

DB10400

biotech approved

Deskripsi

Dermatophagoides farinae extracts are sterile solutions used for intradermal testing or subcutaneous immunotherapy. This combination is approved for as a year-round, once-a-day tablet that's dissolved under the tongue as a treatment for dust mite allergies.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Allergens in ACTAIR consist mainly of proteins and glycoproteins. There is no direct bioavailability of intact allergens in the blood. Therefore, no pharmacokinetic studies in animals or in humans have been carried out to investigate the pharmacokinetic profile and metabolism of ACTAIR.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 25258013
Liu L, Guo D, Liang Q, Ding S, Wu B, Zhang L, Li Q: The efficacy of sublingual immunotherapy with Dermatophagoides farinae vaccine in a murine atopic dermatitis model. Clin Exp Allergy. 2015 Apr;45(4):815-22. doi: 10.1111/cea.12417.
PMID: 7894317
Eremina OIu, Stepanova GN: The mechanism of action of permethrin on house dust mites. Izv Akad Nauk Ser Biol. 1995 Jan-Feb;(1):72-9.
PMID: 26565665
Mauro M, Boni E, Makri E, Incorvaia C: Pharmacodynamic and pharmacokinetic evaluation of house dust mite sublingually administered immunotherapy tablet in the treatment of asthma. Expert Opin Drug Metab Toxicol. 2015;11(12):1937-43. doi: 10.1517/17425255.2015.1113255. Epub 2015 Nov 13.

Link

Contoh Produk & Brand

Produk: 139 • International brands: 0

Produk

Acarizax

Tablet • - • Sublingual • Canada • Approved
Allergen Pack Dermatophagoides Farinae

Kit • - • Intradermal; Subcutaneous • US • Approved
Allergenic Extract - Standardized Mite Dermatophagoides Farinae

Liquid • 5000 unit / mL • Intradermal; Subcutaneous • Canada • Approved
Allergenic Extract - Standardized Mite Dermatophagoides Farinae

Liquid • 10000 unit / mL • Intradermal; Subcutaneous • Canada • Approved
Allergenic Extract - Standardized Mite Mix

Liquid • - • Intradermal; Subcutaneous • Canada • Approved
Allergenic Extract Mixture Of Standardized Mites (15,000 Au/ml)

Solution • - • Percutaneous; Subcutaneous • Canada • Approved
Allergenic Extract Mixture Of Standardized Mites (5,000 Au/ml)

Solution • - • Percutaneous; Subcutaneous • Canada • Approved
Allergenic Extract Standardized Mite DF

Liquid • 10000 unit / mL • Subcutaneous • Canada • Approved

Menampilkan 8 dari 139 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.