Choline C-11

DB09563

small molecule approved

Deskripsi

Choline C 11 Injection is a radioactive diagnostic agent for positron emission tomography (PET) imaging of pat ients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized tomography (CT) or magnetic resonance imaging.

Struktur Molekul 2D

Berat 103.173

Wujud -

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi 11C-choline distributes mainly to the pancreas, kidneys, liver, spleen and colon

Klirens (Clearance) The rate of 11C- choline excretion in urine was 0.014 mL/min.

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Following intravenous administration, 11C-choline undergoes metabolism resulting in the detection of 11C- betaine as the major metabolite in blood. In a study of patients with prostate cancer or brain disorders, the fractional activities of 11C-choline and 11C- betaine in human arterial plasma appeared to reach a plateau within 25 minutes, with 11C- betaine representing 82% ± 9% of the total 11C detected at that time point. A small amount of unmetabolized 11C-choline was detected within the blood at the final sampling time point (40 minutes).

Rute Eliminasi

Urinary excretion of 11C-choline was < 2% of the injected radioactivity at 1.5 hours after injection of the drug.

Interaksi Makanan

2 Data

1. Drink plenty of fluids. Consuming lots of fluid before the PET/CT will reduce excess exposure to radiation by increasing urinary voiding.
2. Take on an empty stomach. Avoid eating for at leats 6 hours before the administration of Choline C-11.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Link

FDA Approved Drug Products: Choline C 11 Injection, for intravenous use

Contoh Produk & Brand

Produk: 10 • International brands: 0

Produk

Choline C 11

Injection • 33.1 mCi/1mL • Intravenous • US • Approved
Choline C 11

Injection • 33.1 mCi/1mL • Intravenous • US • Generic • Approved
Choline C 11

Injection • 100 mCi/1mL • Intravenous • US • Generic • Approved
Choline C 11

Injection • 4 mCi/1mL • Intravenous • US • Generic • Approved
Choline C 11

Injection • 4 mCi/1mL • Intravenous • US • Generic • Approved
Choline C 11

Injection • 33.1 mCi/1mL • Intravenous • US • Approved
Choline C 11

Injection • 33.1 mCi/1mL • Intravenous • US • Generic • Approved
Choline C 11

Injection • 33.1 mCi/1mL • Intravenous • US

Menampilkan 8 dari 10 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.