Sodium glycerophosphate

DB09561

small molecule approved

Deskripsi

Sodium glycerophosphate is one of several glycerophosphate salts. It is used clinically to treat or prevent low phosphate levels FDA Label. Glycerophosphate is hydrolyzed to inorganic phosphate and glycerol in the body ^A32667. The extent of this reaction is dependent on the activity of serum alkaline phosphatases.

Struktur Molekul 2D

Berat 216.036

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Inorganic phosphate has a half-life of elimination of 2.06h [A32667].

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Peak serum phosphate concentration is reached in 4h ^A32667.

Metabolisme

Glycerophosphate is hydrolyzed to form inorganic phosphate ^A32667. The extent of this reaction is dependent on serum alkaline phosphatase activity.

Rute Eliminasi

Inorganic phosphate produced is eliminated in the urine ^A32667. There may be a very small amount of glycerophosphate excreted in the urine unchanged.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 21986180
Topp H, Hochfeld O, Bark S, Grossmann M, Joukhadar C, Westphal M, Straatsma H, Rothenburger M: Glycerophosphate is interchangeable with inorganic phosphate in terms of safety and serum pharmacokinetics. Pharmacology. 2011;88(3-4):193-200. doi: 10.1159/000331341. Epub 2011 Oct 4.

Contoh Produk & Brand

Produk: 13 • International brands: 1

Produk

Glycophos

Injection, solution • 216 mg/1mL • Intravenous • US
Hemarexin Liquid and Drinkable Ampoules

Liquid • - • Oral • Canada • OTC • Approved
Kabiven

Injection, emulsion • - • Intravenous • US • Approved
Olimel 3.3% E

Emulsion • - • Intravenous • Canada • Approved
Olimel 4.4% E

Emulsion • - • Intravenous • Canada • Approved
Olimel 5.7% E

Emulsion • - • Intravenous • Canada • Approved
Olimel 7.6% E

Emulsion • - • Intravenous • Canada • Approved
Perikabiven

Injection, emulsion • - • Intravenous • US • Approved

Menampilkan 8 dari 13 produk.

International Brands

Glycophos — Fresenius Kabi Norge

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.