Peringatan Keamanan

The Ferrlecit iron complex is not dialyzable.L666

No data is available regarding overdose of Ferrlecit in humans. Excessive dosages of Ferrlecit may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Do not administer Ferrlecit to patients with iron overload see Warnings and Precautions (5.3).L666

Individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events see Adverse Reactions (6.2).L666

Ferrlecit at elemental iron doses of 125 mg/kg, 78.8 mg/kg, 62.5 mg/kg, and 250 mg/kg caused deaths in mice, rats, rabbits, and dogs respectively. The major symptoms of acute toxicity were decreased activity, staggering, ataxia, increases in respiratory rate, tremors, and convulsions.L666

Sodium ferric gluconate complex

DB09517

small molecule approved

Deskripsi

Sodium ferric gluconate complex is an iron replacement product for treatment of iron deficiency anemia. The stable macromolecular complex is negatively charged at alkaline pH with an apparent molecular weight of 289,000 – 440,000 daltons on gel chromatography. It is composed of iron (III) oxide hydrate directly bonded to sucrose with a chelating gluconate function in a molar ratio of two iron molecules to one gluconate. It is used in adult and in pediatric patients over the age of 6 years with chronic kidney disease (CKD) receiving hemodialysis and receiving supplemental epoetin therapy.

Struktur Molekul 2D

Berat 2089.309
Wujud liquid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The terminal elimination half-life for drug-bound iron was approximately 1 hour, with the value varying by dose but not by rate of administration. In adults, the shortest terminal elimination half-life of 0.825h occurs with the 62.5 mg/4 min dosing regimen and the longest value of 1.45h is achieved with 125 mg/7 min regimen. In pediatric patients, the half-life was 2 hours following administration of 1.5 mg/kg dose and 2.5 hours following administration of 3.0mg/kg dose.[L666]
Volume Distribusi Using single-dose pharmacokinetics of either 1.5 or 3 mg/kg in pediatric patients (mean age 12.3 ± 2.5 yr), the volume of distribution was estimated to be 1.6 ± 0.6 L.[A18900]
Klirens (Clearance) Total clearance ranges from 3.02 to 5.35 L/h in adult patients.[L666]

Absorpsi

Peak drug levels (Cmax) varied significantly by dosage and by rate of administration. Highest Cmax value is observed in the regimen in which 125 mg was administered in 7 minutes (19.0 mg/L).L666

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

It is renally eliminated if it is greater than 18,000 Daltons.

Interaksi Obat

263 Data
Aldesleukin The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Aldesleukin.
Streptokinase The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Streptokinase.
Valsartan The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Valsartan.
Ramipril The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Ramipril.
Esmolol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Esmolol.
Betaxolol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Betaxolol.
Reserpine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Reserpine.
Torasemide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Torasemide.
Methyclothiazide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Methyclothiazide.
Metoprolol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Metoprolol.
Ropinirole The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Ropinirole.
Isradipine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Isradipine.
Olmesartan The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Olmesartan.
Morphine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Morphine.
Ropivacaine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Ropivacaine.
Bupivacaine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Bupivacaine.
Chlorthalidone The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Chlorthalidone.
Tolcapone The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Tolcapone.
Nitroprusside The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Nitroprusside.
Olanzapine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Olanzapine.
Atenolol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Atenolol.
Diltiazem The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Diltiazem.
Minoxidil The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Minoxidil.
Clozapine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Clozapine.
Timolol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Timolol.
Amlodipine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Amlodipine.
Triamterene The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Triamterene.
Nimodipine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Nimodipine.
Nisoldipine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Nisoldipine.
Pramipexole The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Pramipexole.
Spironolactone The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Spironolactone.
Nitric Oxide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Nitric Oxide.
Bendroflumethiazide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Bendroflumethiazide.
Prazosin The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Prazosin.
Imipramine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Imipramine.
Chlorpromazine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Chlorpromazine.
Brimonidine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Brimonidine.
Nabilone The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Nabilone.
Sotalol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Sotalol.
Fosinopril The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Fosinopril.
Trandolapril The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Trandolapril.
Carteolol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Carteolol.
Metolazone The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Metolazone.
Lercanidipine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Lercanidipine.
Benazepril The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Benazepril.
Propranolol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Propranolol.
Clonidine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Clonidine.
Enalapril The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Enalapril.
Doxazosin The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Doxazosin.
Amiloride The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Amiloride.
Labetalol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Labetalol.
Thiopental The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Thiopental.
Bisoprolol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Bisoprolol.
Nicardipine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Nicardipine.
Clofarabine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Clofarabine.
Dexmedetomidine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Dexmedetomidine.
Mecamylamine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Mecamylamine.
Verapamil The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Verapamil.
Losartan The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Losartan.
Thioridazine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Thioridazine.
Amphotericin B The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Amphotericin B.
Moexipril The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Moexipril.
Phentolamine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Phentolamine.
Furosemide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Furosemide.
Tizanidine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Tizanidine.
Eplerenone The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Eplerenone.
Methazolamide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Methazolamide.
Tamsulosin The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Tamsulosin.
Sufentanil The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Sufentanil.
Apomorphine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Apomorphine.
Lisinopril The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Lisinopril.
Nitroglycerin The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Nitroglycerin.
Mannitol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Mannitol.
Tranylcypromine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Tranylcypromine.
Isoflurane The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Isoflurane.
Hydroflumethiazide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Hydroflumethiazide.
Phenelzine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Phenelzine.
Perindopril The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Perindopril.
Candesartan cilexetil The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Candesartan cilexetil.
Tolazoline The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Tolazoline.
Fenoldopam The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Fenoldopam.
Indapamide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Indapamide.
Propofol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Propofol.
Conivaptan The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Conivaptan.
Eprosartan The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Eprosartan.
Chlorothiazide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Chlorothiazide.
Quinapril The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Quinapril.
Isosorbide dinitrate The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Isosorbide dinitrate.
Bumetanide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Bumetanide.
Remifentanil The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Remifentanil.
Etacrynic acid The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Etacrynic acid.
Levosimendan The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Levosimendan.
Phenoxybenzamine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Phenoxybenzamine.
Pindolol The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Pindolol.
Apraclonidine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Apraclonidine.
Telmisartan The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Telmisartan.
Methyldopa The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Methyldopa.
Dipyridamole The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Dipyridamole.
Hydrochlorothiazide The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Hydrochlorothiazide.
Levobupivacaine The risk or severity of hypotension can be increased when Sodium ferric gluconate complex is combined with Levobupivacaine.

Target Protein

Ferritin light chain FTL
Hemoglobin subunit beta HBB
Hemoglobin subunit alpha HBA1

Referensi & Sumber

Synthesis reference: Geisser, Peter, and Susanna Burckhardt. "The Pharmacokinetics And Pharmacodynamics Of Iron Preparations". Pharmaceutics 3.4 (2011): 12-33. Web. 14 Apr. 2017.
Artikel (PubMed)
  • PMID: 11778670
    Tenenbein M: Hepatotoxicity in acute iron poisoning. J Toxicol Clin Toxicol. 2001;39(7):721-6.
  • PMID: 17942782
    Warady BA, Seligman PA, Dahl NV: Single-dosage pharmacokinetics of sodium ferric gluconate complex in iron-deficient pediatric hemodialysis patients. Clin J Am Soc Nephrol. 2007 Nov;2(6):1140-6. Epub 2007 Oct 17.
  • PMID: 10070910
    Faich G, Strobos J: Sodium ferric gluconate complex in sucrose: safer intravenous iron therapy than iron dextrans. Am J Kidney Dis. 1999 Mar;33(3):464-70.
  • PMID: 17296819
    Henry DH, Dahl NV, Auerbach M, Tchekmedyian S, Laufman LR: Intravenous ferric gluconate significantly improves response to epoetin alfa versus oral iron or no iron in anemic patients with cancer receiving chemotherapy. Oncologist. 2007 Feb;12(2):231-42.
  • PMID: 15971073
    Warady BA, Zobrist RH, Wu J, Finan E: Sodium ferric gluconate complex therapy in anemic children on hemodialysis. Pediatr Nephrol. 2005 Sep;20(9):1320-7. Epub 2005 Jun 22.

Contoh Produk & Brand

Produk: 9 • International brands: 0
Produk
  • Ferrlecit
    Injection • 12.5 mg/1mL • Intravenous • US • Approved
  • Ferrlecit
    Injection • 12.5 mg/1mL • Intravenous • US • Approved
  • Ferrlecit
    Injection • 12.5 mg/1mL • Intravenous • US • Approved
  • Ferrlecit
    Solution • 12.5 mg • Intravenous • Canada • Approved
  • Nulecit
    Injection • 12.5 mg/1mL • Intravenous • US • Generic • Approved
  • Sodium Ferric Gluconate Complex
    Injection • 12.5 mg/1mL • Intravenous • US • Generic • Approved
  • Sodium Ferric Gluconate Complex in Sucrose
    Injection • 12.5 mg/1mL • Intravenous • US • Generic • Approved
  • Sodium Ferric Gluconate Complex in Sucrose
    Injection • 12.5 mg/1mL • Intravenous • US • Generic • Approved
Menampilkan 8 dari 9 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul