Peringatan Keamanan

Data regarding overdoses with simethicone are rare due to the fact that it is not systemically absorbed.^A228308. In the case of an overdose stop the drug^A228308 and initiate symptomatic and supportive care.

Simethicone

DB09512

small molecule approved

Deskripsi

Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination.^A228308 It has a favourable safety profile as it is not systemically absorbed.^A228308

Simethicone has been in use since the 1940s^A228303 but was granted FDA approval in 1952.^A228308

Struktur Molekul 2D

Berat 238.461

Wujud liquid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Simethicone is not systemically absorbed and so these data are not readily available.[A228308]

Volume Distribusi Simethicone is not systemically absorbed and so these data are not readily available.[A228308]

Klirens (Clearance) Simethicone is not systemically absorbed and so these data are not readily available.[A228308]

Absorpsi

Simethicone is not systemically absorbed and so these data are not readily available.^A228308

Metabolisme

Simethicone is not systemically absorbed and so it is not metabolised by the body.^A228308

Rute Eliminasi

Simethicone is eliminated in the feces.^A228308

Interaksi Makanan

1 Data

1. Take with or without food. Recommendations vary from product to product - consult individual product monographs for additional information.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 21000061
KEARNS WM, HEFKE H, MORTON SA: Ditopax; a new excretory urographic medium; a clinical report on 1280 injections. J Urol. 1946 Sep;56:392-8. doi: 10.1016/s0022-5347(17)69822-7.
PMID: 32310457
Ingold CJ, Akhondi H: Simethicone .
PMID: 19554657
Tongprasert S, Sobhonslidsuk A, Rattanasiri S: Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation. World J Gastroenterol. 2009 Jun 28;15(24):3032-7. doi: 10.3748/wjg.15.3032.

Link

Contoh Produk & Brand

Produk: 68 • International brands: 0

Produk

Antacid & Antigas

Suspension • - • Oral • Canada • OTC • Approved
Antacid Plus Antiflatulent - Alumina, Magnesia & Simethicone Oral Suspension

Suspension • - • Oral • Canada • OTC • Approved
Antacid Plus Extra Strength

Solution • - • Oral • Canada • OTC • Approved
Antacid Regular With Anti-gas

Liquid • - • Oral • Canada • OTC • Approved
Antacid With Alumina, Magnesia Plus Simethicone Oral Suspension USP

Suspension • - • Oral • Canada • OTC • Approved
Antacid With Anti-gas Liquid Extra Strength Mint Flavour

Solution • - • Oral • Canada • OTC • Approved
Cancap Simethicone USP 180 Mg Soft Capsules

Capsule • 180 mg • Oral • Canada • OTC • Approved
Diovol Plus Aluminum Free

Tablet, chewable • - • Oral • Canada • OTC • Approved

Menampilkan 8 dari 68 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.