Peringatan Keamanan

During overdose, magnesium impairs neuromuscular transmission resulting in weakness and hypoflexia L593.

Magnesium carbonate

DB09481

small molecule approved investigational

Deskripsi

Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach FDA Label.

Struktur Molekul 2D

Berat 84.314
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Half life of 27.7 hours reported with overdose of 400mEq of magnesium in an adult [L593].
Volume Distribusi Vd for magnesium is 0.2-0.4L/kg [L593]. About 50% distributes to bone.
Klirens (Clearance) Maximum magnesium clearance is directly proportional to creatinine clearance [L593].

Absorpsi

About 40-60% of magnesium is absorbed following oral administration L593. Percent absorption decreases as dose increases.

Metabolisme

Magnesium does not appear to be metabolized in any way L593.

Rute Eliminasi

Primarily eliminated in urine L593.

Interaksi Obat

1293 Data
Succinylcholine The therapeutic efficacy of Succinylcholine can be increased when used in combination with Magnesium carbonate.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Magnesium carbonate.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Magnesium carbonate.
Cisatracurium Magnesium carbonate may increase the neuromuscular blocking activities of Cisatracurium.
Rocuronium The therapeutic efficacy of Rocuronium can be increased when used in combination with Magnesium carbonate.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Magnesium carbonate.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium carbonate.
Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Magnesium carbonate.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium carbonate.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Magnesium carbonate.
Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Magnesium carbonate.
Pipecuronium The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium carbonate.
Vecuronium The therapeutic efficacy of Vecuronium can be increased when used in combination with Magnesium carbonate.
Rapacuronium The therapeutic efficacy of Rapacuronium can be increased when used in combination with Magnesium carbonate.
Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Magnesium carbonate.
Neosaxitoxin The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Magnesium carbonate.
Atracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Magnesium carbonate.
Gallamine The therapeutic efficacy of Gallamine can be increased when used in combination with Magnesium carbonate.
Alcuronium The therapeutic efficacy of Alcuronium can be increased when used in combination with Magnesium carbonate.
Tubocurarine The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium carbonate.
Atazanavir Magnesium carbonate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bosutinib Magnesium carbonate can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cefditoren The serum concentration of Cefditoren can be decreased when it is combined with Magnesium carbonate.
Dabigatran etexilate Magnesium carbonate can cause a decrease in the absorption of Dabigatran etexilate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dabrafenib Magnesium carbonate can cause a decrease in the absorption of Dabrafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dasatinib Magnesium carbonate can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delavirdine Magnesium carbonate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Erlotinib Magnesium carbonate can cause a decrease in the absorption of Erlotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gefitinib Magnesium carbonate can cause a decrease in the absorption of Gefitinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Itraconazole Magnesium carbonate can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ledipasvir Magnesium carbonate can cause a decrease in the absorption of Ledipasvir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylphenidate Magnesium carbonate can cause an increase in the absorption of Methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
Pazopanib Magnesium carbonate can cause a decrease in the absorption of Pazopanib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Riociguat Magnesium carbonate can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcitriol The serum concentration of Magnesium carbonate can be increased when it is combined with Calcitriol.
Calcifediol The serum concentration of Magnesium carbonate can be increased when it is combined with Calcifediol.
Cholecalciferol The serum concentration of Magnesium carbonate can be increased when it is combined with Cholecalciferol.
Paricalcitol The serum concentration of Magnesium carbonate can be increased when it is combined with Paricalcitol.
Dihydrotachysterol The serum concentration of Magnesium carbonate can be increased when it is combined with Dihydrotachysterol.
Alfacalcidol The serum concentration of Magnesium carbonate can be increased when it is combined with Alfacalcidol.
Seocalcitol The serum concentration of Magnesium carbonate can be increased when it is combined with Seocalcitol.
Inecalcitol The serum concentration of Magnesium carbonate can be increased when it is combined with Inecalcitol.
Becocalcidiol The serum concentration of Magnesium carbonate can be increased when it is combined with Becocalcidiol.
Eldecalcitol The serum concentration of Magnesium carbonate can be increased when it is combined with Eldecalcitol.
1alpha,24S-Dihydroxyvitamin D2 The serum concentration of Magnesium carbonate can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
Elocalcitol The serum concentration of Magnesium carbonate can be increased when it is combined with Elocalcitol.
Maxacalcitol The serum concentration of Magnesium carbonate can be increased when it is combined with Maxacalcitol.
Doxercalciferol The serum concentration of Magnesium carbonate can be increased when it is combined with Doxercalciferol.
Vitamin D The serum concentration of Magnesium carbonate can be increased when it is combined with Vitamin D.
1alpha-Hydroxyvitamin D5 The serum concentration of Magnesium carbonate can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
Previtamin D(3) The serum concentration of Magnesium carbonate can be increased when it is combined with Previtamin D(3).
Deferiprone Magnesium carbonate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dolutegravir Magnesium carbonate can cause a decrease in the absorption of Dolutegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eltrombopag Magnesium carbonate can cause a decrease in the absorption of Eltrombopag resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levothyroxine Magnesium carbonate can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tolevamer The risk or severity of adverse effects can be increased when Tolevamer is combined with Magnesium carbonate.
Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Magnesium carbonate.
Captopril Magnesium carbonate can cause a decrease in the absorption of Captopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cefpodoxime The serum concentration of Cefpodoxime can be decreased when it is combined with Magnesium carbonate.
Cefuroxime The serum concentration of Cefuroxime can be decreased when it is combined with Magnesium carbonate.
Chloroquine Magnesium carbonate can cause a decrease in the absorption of Chloroquine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Elvitegravir Magnesium carbonate can cause a decrease in the absorption of Elvitegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gabapentin enacarbil The serum concentration of Gabapentin enacarbil can be decreased when it is combined with Magnesium carbonate.
Hyoscyamine Magnesium carbonate can cause a decrease in the absorption of Hyoscyamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rifampin Magnesium carbonate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mecamylamine Magnesium carbonate may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
Memantine Magnesium carbonate may decrease the excretion rate of Memantine which could result in a higher serum level.
Penicillamine Magnesium carbonate can cause a decrease in the absorption of Penicillamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Quinidine Magnesium carbonate may decrease the excretion rate of Quinidine which could result in a higher serum level.
Quinine Magnesium carbonate can cause a decrease in the absorption of Quinine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sotalol The serum concentration of Sotalol can be decreased when it is combined with Magnesium carbonate.
Sulpiride The therapeutic efficacy of Sulpiride can be increased when used in combination with Magnesium carbonate.
Deferasirox Magnesium carbonate can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol The therapeutic efficacy of Allopurinol can be decreased when used in combination with Magnesium carbonate.
Fexofenadine Magnesium carbonate can cause a decrease in the absorption of Fexofenadine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raltegravir Magnesium carbonate can cause a decrease in the absorption of Raltegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Halofantrine Magnesium carbonate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Misoprostol The risk or severity of adverse effects can be increased when Magnesium carbonate is combined with Misoprostol.
Mesalazine Magnesium carbonate can cause a decrease in the absorption of Mesalazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cysteamine The bioavailability of Cysteamine can be decreased when combined with Magnesium carbonate.
Ketoconazole Magnesium carbonate can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trospium The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Trospium.
Oxyphenonium The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Oxyphenonium.
Ziprasidone The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Ziprasidone.
Ipratropium The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Ipratropium.
Olanzapine The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Olanzapine.
Metixene The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Metixene.
Terfenadine The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Terfenadine.
Buclizine The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Buclizine.
Doxylamine The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Doxylamine.
Trihexyphenidyl The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Trihexyphenidyl.
Oxyphencyclimine The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Oxyphencyclimine.
Procyclidine The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Procyclidine.
Profenamine The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Profenamine.
Cyproheptadine The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Cyproheptadine.
Methscopolamine bromide The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Methscopolamine bromide.
Darifenacin The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Darifenacin.
Tridihexethyl The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Tridihexethyl.
Anisotropine methylbromide The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Anisotropine methylbromide.
Nortriptyline The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Nortriptyline.

Target Protein

Glutamate (NMDA) receptor GRIN1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 26446763
    de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388.
  • PMID: 26069819
    Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163.
  • PMID: 22261381
    Nikolaev MV, Magazanik LG, Tikhonov DB: Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations. Neuropharmacology. 2012 Apr;62(5-6):2078-85. doi: 10.1016/j.neuropharm.2011.12.029. Epub 2012 Jan 12.

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