Peringatan Keamanan

Glycerol has very low toxicity when ingested ;
Rat LD50 (oral)-12600mg/kg
Mice LD50 (oral )-4090mg/kg
Human TDLo (oral) - 1428mg/kg

Glycerin

DB09462

small molecule approved investigational

Deskripsi

A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.

Struktur Molekul 2D

Berat 92.0938
Wujud -

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 30 - 45 minutes
Volume Distribusi Glycerin is distributed throughout the blood. Although glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.
Klirens (Clearance) -

Absorpsi

Well absorbed orally, poorly absorbed rectally. Studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach

Metabolisme

Glycerin is a substrate for synthesis of triacylglycerols and of phospholipids in the liver and adipose tissue. When fat metabolized as a source of energy, glycerol and fatty acids are released into the bloodstream. Circulating glycerin does not glycate proteins and does not lead to the formation of advanced glycation endproducts (AGEs). In some organisms, the glycerin component can enter the glycolysis pathway directly to provide a substrate for energy or glucose production. Glycerol must be converted to their intermediate glyceraldehyde 3-phosphate before being used in glycolysis or gluconeogenesis. Glycerol metabolism is regulated by the enzymes glycerol kinase, (cytosolic) NAD+-dependent G3P dehydrogenase and (mitochondrial) FAD-linked G3P dehydrogenase.

Rute Eliminasi

Approx 7-14% of dose is excreted unchanged in the urine within 2.5 hr.

Interaksi Obat

427 Data
Trospium The therapeutic efficacy of Glycerin can be decreased when used in combination with Trospium.
Oxyphenonium The therapeutic efficacy of Glycerin can be decreased when used in combination with Oxyphenonium.
Benzatropine The therapeutic efficacy of Glycerin can be decreased when used in combination with Benzatropine.
Ziprasidone The therapeutic efficacy of Glycerin can be decreased when used in combination with Ziprasidone.
Disopyramide The therapeutic efficacy of Glycerin can be decreased when used in combination with Disopyramide.
Ipratropium The therapeutic efficacy of Glycerin can be decreased when used in combination with Ipratropium.
Metixene The therapeutic efficacy of Glycerin can be decreased when used in combination with Metixene.
Buclizine The therapeutic efficacy of Glycerin can be decreased when used in combination with Buclizine.
Doxylamine The therapeutic efficacy of Glycerin can be decreased when used in combination with Doxylamine.
Trihexyphenidyl The therapeutic efficacy of Glycerin can be decreased when used in combination with Trihexyphenidyl.
Oxyphencyclimine The therapeutic efficacy of Glycerin can be decreased when used in combination with Oxyphencyclimine.
Procyclidine The therapeutic efficacy of Glycerin can be decreased when used in combination with Procyclidine.
Profenamine The therapeutic efficacy of Glycerin can be decreased when used in combination with Profenamine.
Promazine The therapeutic efficacy of Glycerin can be decreased when used in combination with Promazine.
Hyoscyamine The therapeutic efficacy of Glycerin can be decreased when used in combination with Hyoscyamine.
Cyproheptadine The therapeutic efficacy of Glycerin can be decreased when used in combination with Cyproheptadine.
Methscopolamine bromide The therapeutic efficacy of Glycerin can be decreased when used in combination with Methscopolamine bromide.
Gallamine triethiodide The therapeutic efficacy of Glycerin can be decreased when used in combination with Gallamine triethiodide.
Darifenacin The therapeutic efficacy of Glycerin can be decreased when used in combination with Darifenacin.
Tridihexethyl The therapeutic efficacy of Glycerin can be decreased when used in combination with Tridihexethyl.
Triflupromazine The therapeutic efficacy of Glycerin can be decreased when used in combination with Triflupromazine.
Anisotropine methylbromide The therapeutic efficacy of Glycerin can be decreased when used in combination with Anisotropine methylbromide.
Nortriptyline The therapeutic efficacy of Glycerin can be decreased when used in combination with Nortriptyline.
Amoxapine The therapeutic efficacy of Glycerin can be decreased when used in combination with Amoxapine.
Atropine The therapeutic efficacy of Glycerin can be decreased when used in combination with Atropine.
Pirenzepine The therapeutic efficacy of Glycerin can be decreased when used in combination with Pirenzepine.
Paroxetine The therapeutic efficacy of Glycerin can be decreased when used in combination with Paroxetine.
Homatropine methylbromide The therapeutic efficacy of Glycerin can be decreased when used in combination with Homatropine methylbromide.
Rocuronium The therapeutic efficacy of Glycerin can be decreased when used in combination with Rocuronium.
Scopolamine The therapeutic efficacy of Glycerin can be decreased when used in combination with Scopolamine.
Benzquinamide The therapeutic efficacy of Glycerin can be decreased when used in combination with Benzquinamide.
Clidinium The therapeutic efficacy of Glycerin can be decreased when used in combination with Clidinium.
Propiomazine The therapeutic efficacy of Glycerin can be decreased when used in combination with Propiomazine.
Propantheline The therapeutic efficacy of Glycerin can be decreased when used in combination with Propantheline.
Dicyclomine The therapeutic efficacy of Glycerin can be decreased when used in combination with Dicyclomine.
Biperiden The therapeutic efficacy of Glycerin can be decreased when used in combination with Biperiden.
Brompheniramine The therapeutic efficacy of Glycerin can be decreased when used in combination with Brompheniramine.
Cocaine The therapeutic efficacy of Glycerin can be decreased when used in combination with Cocaine.
Maprotiline The therapeutic efficacy of Glycerin can be decreased when used in combination with Maprotiline.
Methantheline The therapeutic efficacy of Glycerin can be decreased when used in combination with Methantheline.
Cycrimine The therapeutic efficacy of Glycerin can be decreased when used in combination with Cycrimine.
Glycopyrronium The therapeutic efficacy of Glycerin can be decreased when used in combination with Glycopyrronium.
Tolterodine The therapeutic efficacy of Glycerin can be decreased when used in combination with Tolterodine.
Oxybutynin The therapeutic efficacy of Glycerin can be decreased when used in combination with Oxybutynin.
Promethazine The therapeutic efficacy of Glycerin can be decreased when used in combination with Promethazine.
Diphenhydramine The therapeutic efficacy of Glycerin can be decreased when used in combination with Diphenhydramine.
Doxacurium The therapeutic efficacy of Glycerin can be decreased when used in combination with Doxacurium.
Flavoxate The therapeutic efficacy of Glycerin can be decreased when used in combination with Flavoxate.
Desipramine The therapeutic efficacy of Glycerin can be decreased when used in combination with Desipramine.
Orphenadrine The therapeutic efficacy of Glycerin can be decreased when used in combination with Orphenadrine.
Escitalopram The therapeutic efficacy of Glycerin can be decreased when used in combination with Escitalopram.
Mivacurium The therapeutic efficacy of Glycerin can be decreased when used in combination with Mivacurium.
Diphenidol The therapeutic efficacy of Glycerin can be decreased when used in combination with Diphenidol.
Aripiprazole The therapeutic efficacy of Glycerin can be decreased when used in combination with Aripiprazole.
Chlorprothixene The therapeutic efficacy of Glycerin can be decreased when used in combination with Chlorprothixene.
Metocurine The therapeutic efficacy of Glycerin can be decreased when used in combination with Metocurine.
Pancuronium The therapeutic efficacy of Glycerin can be decreased when used in combination with Pancuronium.
Pipecuronium The therapeutic efficacy of Glycerin can be decreased when used in combination with Pipecuronium.
Methotrimeprazine The therapeutic efficacy of Glycerin can be decreased when used in combination with Methotrimeprazine.
Tiotropium The therapeutic efficacy of Glycerin can be decreased when used in combination with Tiotropium.
Solifenacin The therapeutic efficacy of Glycerin can be decreased when used in combination with Solifenacin.
Isopropamide The therapeutic efficacy of Glycerin can be decreased when used in combination with Isopropamide.
Rapacuronium The therapeutic efficacy of Glycerin can be decreased when used in combination with Rapacuronium.
Mepenzolate The therapeutic efficacy of Glycerin can be decreased when used in combination with Mepenzolate.
Pizotifen The therapeutic efficacy of Glycerin can be decreased when used in combination with Pizotifen.
Hexocyclium The therapeutic efficacy of Glycerin can be decreased when used in combination with Hexocyclium.
Dimetindene The therapeutic efficacy of Glycerin can be decreased when used in combination with Dimetindene.
Aclidinium The therapeutic efficacy of Glycerin can be decreased when used in combination with Aclidinium.
Dexetimide The therapeutic efficacy of Glycerin can be decreased when used in combination with Dexetimide.
Benactyzine The therapeutic efficacy of Glycerin can be decreased when used in combination with Benactyzine.
Trimebutine The therapeutic efficacy of Glycerin can be decreased when used in combination with Trimebutine.
Dosulepin The therapeutic efficacy of Glycerin can be decreased when used in combination with Dosulepin.
Imidafenacin The therapeutic efficacy of Glycerin can be decreased when used in combination with Imidafenacin.
Butylscopolamine The therapeutic efficacy of Glycerin can be decreased when used in combination with Butylscopolamine.
Thonzylamine The therapeutic efficacy of Glycerin can be decreased when used in combination with Thonzylamine.
Methscopolamine The therapeutic efficacy of Glycerin can be decreased when used in combination with Methscopolamine.
Oxitropium The therapeutic efficacy of Glycerin can be decreased when used in combination with Oxitropium.
Propiverine The therapeutic efficacy of Glycerin can be decreased when used in combination with Propiverine.
Batefenterol The therapeutic efficacy of Glycerin can be decreased when used in combination with Batefenterol.
Mebeverine The therapeutic efficacy of Glycerin can be decreased when used in combination with Mebeverine.
Tropatepine The therapeutic efficacy of Glycerin can be decreased when used in combination with Tropatepine.
Prifinium The therapeutic efficacy of Glycerin can be decreased when used in combination with Prifinium.
Piperidolate The therapeutic efficacy of Glycerin can be decreased when used in combination with Piperidolate.
Benzilone The therapeutic efficacy of Glycerin can be decreased when used in combination with Benzilone.
Difemerine The therapeutic efficacy of Glycerin can be decreased when used in combination with Difemerine.
Phenglutarimide The therapeutic efficacy of Glycerin can be decreased when used in combination with Phenglutarimide.
Mazaticol The therapeutic efficacy of Glycerin can be decreased when used in combination with Mazaticol.
Etybenzatropine The therapeutic efficacy of Glycerin can be decreased when used in combination with Etybenzatropine.
Otilonium The therapeutic efficacy of Glycerin can be decreased when used in combination with Otilonium.
Emepronium The therapeutic efficacy of Glycerin can be decreased when used in combination with Emepronium.
Poldine The therapeutic efficacy of Glycerin can be decreased when used in combination with Poldine.
Bevonium The therapeutic efficacy of Glycerin can be decreased when used in combination with Bevonium.
Rociverine The therapeutic efficacy of Glycerin can be decreased when used in combination with Rociverine.
Bornaprine The therapeutic efficacy of Glycerin can be decreased when used in combination with Bornaprine.
Etanautine The therapeutic efficacy of Glycerin can be decreased when used in combination with Etanautine.
Tiemonium iodide The therapeutic efficacy of Glycerin can be decreased when used in combination with Tiemonium iodide.
Dihexyverine The therapeutic efficacy of Glycerin can be decreased when used in combination with Dihexyverine.
Penthienate The therapeutic efficacy of Glycerin can be decreased when used in combination with Penthienate.
Diphemanil The therapeutic efficacy of Glycerin can be decreased when used in combination with Diphemanil.
Camylofin The therapeutic efficacy of Glycerin can be decreased when used in combination with Camylofin.

Target Protein

Peroxisome proliferator-activated receptor delta PPARD
Group IIE secretory phospholipase A2 PLA2G2E
Inositol-3-phosphate synthase 1 ISYNA1
All-trans-retinol dehydrogenase [NAD(+)] ADH1B ADH1B
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 ITPR1
Glycodelin PAEP
Alpha-N-acetylgalactosaminidase NAGA
ADP-ribosylation factor 1 ARF1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 PAPSS1
DNA mismatch repair protein MutL mutL
Ribonucleoside-diphosphate reductase 1 subunit beta nrdB
Adenine DNA glycosylase mutY
tRNA (cytosine(38)-C(5))-methyltransferase TRDMT1
Maleylacetoacetate isomerase GSTZ1

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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