Peringatan Keamanan

Man: LD50 (Oral) - 714 mg/kg, Effect: Behavioural,General Anesthetic : GI Ulceration or Bleeding from small intestine.
Mouse : LC50 ( Inhalation ) - 1200mg/m3/2h : GI Other Change
Mouse : LC50 ( Intraperitoneal ) - 117mg/kg
Mouse : LD50 ( Oral) - 6600mg/kg
Mouse : LD50 (Subcutaneous ) - 2210 mg/kg
Rat : LC50 ( Inhalation ) 2300mg/m3/2H
Rat: LD50 (Oral) - 4090 mg/kg

Sodium carbonate

DB09460

small molecule approved

Deskripsi

Sodium Carbonate is the disodium salt of carbonic acid with alkalinizing property. When dissolved in water, sodium carbonate forms carbonic acid and sodium hydroxide. As a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid.

Struktur Molekul 2D

Berat 105.9884

Wujud -

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi Distribution occurs naturally and is confined to the systemic circulation.

Klirens (Clearance) -

Absorpsi

The uptake of sodium, via exposure to sodium carbonate, is much less than the uptake of sodium via food. Therefore, sodium carbonate is not expected to be systemically available in the body. Furthermore, an oral uptake of sodium carbonate will result in a neutralization in the stomach due to the gastric acid.

Metabolisme

None.

Rute Eliminasi

Filtered and reabsorbed by the kidney; less than 1% of filtered bicarbonate is excreted.

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

Carbonic anhydrase 1 CA1

Carbonic anhydrase 2 CA2

Carbonic anhydrase 4 CA4

Carbonic anhydrase 9 CA9

Referensi & Sumber

Link

Contoh Produk & Brand

Produk: 6 • International brands: 0

Produk

Carbicarb Injection

Liquid • - • Intravenous • Canada • Approved
Sel De Perou

Powder • - • Topical • Canada • OTC • Approved
Sels Mexicain

Powder • - • Topical • Canada • OTC • Approved
Urologic G for Irrigation

Solution • - • Irrigation • Canada • Approved
Urologic G for Irrigation

Solution • - • Irrigation • Canada • Approved
Urologic Solution G

Liquid • - • Irrigation • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.