Peringatan Keamanan

There is no information on the LD₅₀ of technetium Tc-99m succimer.

In the event of an overdose of technetium Tc-99m succimer, reduce the radiation absorbed dose to the patient where possible by increasing the elimination of the drug from the body using hydration and frequent bladder voiding. A diuretic might also be considered. If possible, an estimate of the radiation-effective dose given to the patient should be made.^L40558

Technetium Tc-99m succimer

DB09436

small molecule approved

Deskripsi

Technetium Tc-99m (^99mTc) succimer, also known as technetium Tc-99m dimercaptosuccinic acid (DMSA),^A245643 is a radioactive diagnostic agent used to evaluate functional renal tissue and tubular function in patients with renal parenchymal disorders. It works by binding to the cortical region of the kidneys. Technetium Tc-99m succimer is used with gamma scintigraphy or single-photon emission computed tomography (SPECT).^L40558 The use of technetium Tc-99m succimer for the detection of kidney cortical defects was first approved by the FDA on February 23, 2022, under the market name NephroScan.^L40573

Struktur Molekul 2D

Berat 281.11

Wujud -

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Technetium Tc-99m decays by isomeric transition with a physical half-life of 6.02 hours.[L40558]

Volume Distribusi There is no information available.

Klirens (Clearance) There is no information available.

Absorpsi

Upon intravenous administration, technetium Tc-99m succimer penetrates the glomerular filter at very low rates.^A245658

Metabolisme

Technetium Tc-99m decays via isomeric transition.^L40558

Rute Eliminasi

Approximately 16% of the technetium Tc-99m succimer activity is excreted in the urine within two hours.^L40558 Technetium Tc-99m succimer in the tubular system is completely excreted and not reabsorbed from the tubular fluid.^A245658

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 23608072
Galbraith W, Nguyen A, Harrison DL, Chen X, Talley K: Evaluation of 99mTc-succimer dosing in pediatric patients. J Nucl Med Technol. 2013 Jun;41(2):81-4. doi: 10.2967/jnmt.112.118836. Epub 2013 Apr 22.
PMID: 7658227
Muller-Suur R, Gutsche HU: Tubular reabsorption of technetium-99m-DMSA. J Nucl Med. 1995 Sep;36(9):1654-8.
PMID: 20852370
Mohkam M, Maham S, Rahmani A, Naghi I, Otokesh B, Raiiati H, Mohseni N, Shamshiri AR, Sharifian M, Dalirani R, Ghazi R, Ahoopai M: Technetium Tc 99m dimercaptosuccinic acid renal scintigraphy in children with acute pyelonephritis: correlation with other imaging tests. Iran J Kidney Dis. 2010 Oct;4(4):297-301.
PMID: 2827323
Copely DJ, Smith R, Murakami ME: Renal scintigraphy with technetium Tc 99m succimer: clinical utility in newborns with cystic renal dysplasia. South Med J. 1988 Jan;81(1):99-100. doi: 10.1097/00007611-198801000-00025.

Link

Contoh Produk & Brand

Produk: 0 • International brands: 0

Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.