Peringatan Keamanan

Rabbit : LD50 >4640mg/kg (skin)
Rat : LdLo : 4640mg/kg (Oral)

Monopotassium phosphate

DB09413

small molecule approved investigational vet_approved

Deskripsi

Monopotassium phosphate, MKP, (also potassium dihydrogenphosphate, KDP, or monobasic potassium phosphate), KH2PO4, is a soluble salt of potassium and the dihydrogen phosphate ion. It is a source of phosphorus and potassium as well as a buffering agent. It can be used in fertilizer mixtures to reduce escape of ammonia by keeping pH low.

Struktur Molekul 2D

Berat 136.0855
Wujud -

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) In healthy children with phosphate overdose, half-life was 4.8 to 10.6 hours, and was prolonged to 17 hours in a child with renal insufficiency.
Volume Distribusi Potassium first enters the extracellular fluid and is then actively transported into the cells where its concentration is up to 40 times that outside the cell. Dextrose, insulin, and oxygen facilitate movement of potassium into cells.
Klirens (Clearance) Phosphates are rapidly cleared by dialysis. Dialysis can also be used to treat other electrolyte abnormalities such as hypernatremia, hypocalcemia, and hypomagnesemia.

Absorpsi

Potassium salts are well absorbed from the GI tract. Ingested phosphates are absorbed from the gastrointestinal tract. However, the presence of large amounts of calcium or aluminum may lead to formation of insoluble phosphate and reduce the net absorption. Vitamin D stimulates phosphate absorption.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Renal (90%) and fecal (10%) Phosphates Potassium is excreted mainly by the kidneys. Small amounts of potassium may be excreted via the skin and intestinal tract, but most of the potassium excreted into the intestine is later reabsorbed.

Interaksi Makanan

3 Data
  • 1. Take separate from antacids. Magnesium, calcium, or aluminum antacids may reduce the absorption of phosphate in K-phos.
  • 2. Take with a full glass of water. Dissolve K-Phos tablets in water then ingest.
  • 3. Take with food. Take K-Phos tablets at bedtime and with meals.

Interaksi Obat

664 Data
Tramadol The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Tramadol.
Trospium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Trospium.
Oxyphenonium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Oxyphenonium.
Benzatropine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Benzatropine.
Ziprasidone The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Ziprasidone.
Disopyramide The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Disopyramide.
Amitriptyline The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Amitriptyline.
Ipratropium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Ipratropium.
Olanzapine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Olanzapine.
Metixene The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Metixene.
Terfenadine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Terfenadine.
Buclizine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Buclizine.
Clozapine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Clozapine.
Doxylamine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Doxylamine.
Trihexyphenidyl The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Trihexyphenidyl.
Oxyphencyclimine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Oxyphencyclimine.
Procyclidine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Procyclidine.
Profenamine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Profenamine.
Promazine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Promazine.
Hyoscyamine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Hyoscyamine.
Cyproheptadine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Cyproheptadine.
Imipramine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Imipramine.
Methscopolamine bromide The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Methscopolamine bromide.
Chlorpromazine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Chlorpromazine.
Gallamine triethiodide The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Gallamine triethiodide.
Darifenacin The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Darifenacin.
Tridihexethyl The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Tridihexethyl.
Triflupromazine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Triflupromazine.
Anisotropine methylbromide The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Anisotropine methylbromide.
Nortriptyline The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Nortriptyline.
Amoxapine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Amoxapine.
Atropine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Atropine.
Pirenzepine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Pirenzepine.
Paroxetine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Paroxetine.
Homatropine methylbromide The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Homatropine methylbromide.
Rocuronium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Rocuronium.
Scopolamine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Scopolamine.
Benzquinamide The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Benzquinamide.
Clidinium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Clidinium.
Propiomazine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Propiomazine.
Propantheline The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Propantheline.
Dicyclomine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Dicyclomine.
Biperiden The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Biperiden.
Brompheniramine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Brompheniramine.
Flupentixol The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Flupentixol.
Cocaine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Cocaine.
Quinidine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Quinidine.
Maprotiline The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Maprotiline.
Methantheline The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Methantheline.
Cycrimine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Cycrimine.
Glycopyrronium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Glycopyrronium.
Tolterodine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Tolterodine.
Oxybutynin The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Oxybutynin.
Promethazine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Promethazine.
Diphenhydramine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Diphenhydramine.
Doxacurium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Doxacurium.
Doxepin The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Doxepin.
Flavoxate The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Flavoxate.
Desipramine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Desipramine.
Orphenadrine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Orphenadrine.
Escitalopram The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Escitalopram.
Quetiapine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Quetiapine.
Mivacurium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Mivacurium.
Diphenidol The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Diphenidol.
Aripiprazole The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Aripiprazole.
Chlorprothixene The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Chlorprothixene.
Metocurine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Metocurine.
Pancuronium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Pancuronium.
Pipecuronium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Pipecuronium.
Methotrimeprazine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Methotrimeprazine.
Tiotropium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Tiotropium.
Solifenacin The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Solifenacin.
Isopropamide The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Isopropamide.
Rapacuronium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Rapacuronium.
Mepenzolate The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Mepenzolate.
Pizotifen The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Pizotifen.
Fesoterodine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Fesoterodine.
Hexocyclium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Hexocyclium.
Dimetindene The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Dimetindene.
Aclidinium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Aclidinium.
Dexetimide The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Dexetimide.
Benactyzine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Benactyzine.
Umeclidinium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Umeclidinium.
Dosulepin The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Dosulepin.
Imidafenacin The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Imidafenacin.
Butylscopolamine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Butylscopolamine.
Thonzylamine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Thonzylamine.
Methscopolamine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Methscopolamine.
Revefenacin The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Revefenacin.
Oxitropium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Oxitropium.
Propiverine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Propiverine.
Batefenterol The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Batefenterol.
Mebeverine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Mebeverine.
Tropatepine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Tropatepine.
Prifinium The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Prifinium.
Piperidolate The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Piperidolate.
Benzilone The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Benzilone.
Difemerine The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Difemerine.
Phenglutarimide The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Phenglutarimide.
Mazaticol The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Mazaticol.

Referensi & Sumber

Contoh Produk & Brand

Produk: 55 • International brands: 0
Produk
  • Artisial
    Liquid • - • Buccal • Canada • OTC • Approved
  • Av-Phos 250 Neutral
    Tablet • - • Oral • US
  • Dextrose 5% and Electrolyte No75 Inj
    Liquid • - • Intravenous • Canada • Approved
  • Dextrose and Electrolyte No. 48
    Injection • - • Intravenous • US • Approved
  • Dextrose and Electrolyte No. 75
    Injection, solution • - • Intravenous • US • Approved
  • Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium Phosphate
    Tablet • - • Oral • US
  • Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium Phosphate
    Tablet • - • Oral • US
  • Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium Phosphate
    Tablet • - • Oral • US
Menampilkan 8 dari 55 produk.

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