Peringatan Keamanan

Predicted oral LD50 value is >2000mg/kg. In case of mild to moderate toxicity, it may cause irritation in case of skin or eye contact,and nausea or vomiting from ingestion and inhalation. In overdose, magnesium impairs neuromuscular transmission, manifested as weakness and hyporeflexia. Early manifestations of severe toxicity are lethargy, hyporeflexia, followed by weakness, paralysis, hypotension, ECG changes (prolonged PR and QRS intervals), CNS depression, seizures, and respiratory depression.

Magnesium acetate tetrahydrate

DB09409

small molecule approved

Deskripsi

Magnesium acetate tetrahydrate is a hydrated form of anhydrous magnesium acetate salt with the chemical formula of Mg(CH3COO)2
• 4H2O. As a salt form of magnesium, magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble compound. Magnesium is an essential element and second most abundant cation in the body that plays a key role in maintaining normal cellular function such as production of ATP and efficient enzyme activity. Magnesium acetate tetrahydrate can be used as an electrolyte supplementation or a reagent in molecular biology experiments.

Struktur Molekul 2D

Berat 214.453
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Elimination half-life has been reported to be 27.7 hours following an overdose of 400mEq magnesium in an adult.
Volume Distribusi Magnesium ions display approximate volume of distribution of 0.2 to 0.4 L/kg
Klirens (Clearance) -

Absorpsi

Intestinal absorption is achieved mainly through passive diffusion.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Mainly renal exctretion, where up to 97% of magnesium may be excreted renally during hypermagnesemia.

Interaksi Obat

273 Data
Succinylcholine The therapeutic efficacy of Succinylcholine can be increased when used in combination with Magnesium acetate tetrahydrate.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Magnesium acetate tetrahydrate.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Magnesium acetate tetrahydrate.
Cisatracurium The therapeutic efficacy of Cisatracurium can be increased when used in combination with Magnesium acetate tetrahydrate.
Rocuronium The therapeutic efficacy of Rocuronium can be increased when used in combination with Magnesium acetate tetrahydrate.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Magnesium acetate tetrahydrate.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium acetate tetrahydrate.
Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Magnesium acetate tetrahydrate.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium acetate tetrahydrate.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Magnesium acetate tetrahydrate.
Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Magnesium acetate tetrahydrate.
Pipecuronium The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium acetate tetrahydrate.
Vecuronium The therapeutic efficacy of Vecuronium can be increased when used in combination with Magnesium acetate tetrahydrate.
Rapacuronium The therapeutic efficacy of Rapacuronium can be increased when used in combination with Magnesium acetate tetrahydrate.
Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Magnesium acetate tetrahydrate.
Neosaxitoxin The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Magnesium acetate tetrahydrate.
Atracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Magnesium acetate tetrahydrate.
Gallamine The therapeutic efficacy of Gallamine can be increased when used in combination with Magnesium acetate tetrahydrate.
Alcuronium The therapeutic efficacy of Alcuronium can be increased when used in combination with Magnesium acetate tetrahydrate.
Tubocurarine The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium acetate tetrahydrate.
Torasemide The risk or severity of dehydration can be increased when Torasemide is combined with Magnesium acetate tetrahydrate.
Methyclothiazide The risk or severity of dehydration can be increased when Methyclothiazide is combined with Magnesium acetate tetrahydrate.
Chlorthalidone The risk or severity of dehydration can be increased when Chlorthalidone is combined with Magnesium acetate tetrahydrate.
Ethoxzolamide The risk or severity of dehydration can be increased when Ethoxzolamide is combined with Magnesium acetate tetrahydrate.
Triamterene The risk or severity of dehydration can be increased when Triamterene is combined with Magnesium acetate tetrahydrate.
Spironolactone The risk or severity of dehydration can be increased when Spironolactone is combined with Magnesium acetate tetrahydrate.
Bendroflumethiazide The risk or severity of dehydration can be increased when Bendroflumethiazide is combined with Magnesium acetate tetrahydrate.
Metolazone The risk or severity of dehydration can be increased when Metolazone is combined with Magnesium acetate tetrahydrate.
Benzthiazide The risk or severity of dehydration can be increased when Benzthiazide is combined with Magnesium acetate tetrahydrate.
Amiloride The risk or severity of dehydration can be increased when Amiloride is combined with Magnesium acetate tetrahydrate.
Cyclothiazide The risk or severity of dehydration can be increased when Cyclothiazide is combined with Magnesium acetate tetrahydrate.
Furosemide The risk or severity of dehydration can be increased when Furosemide is combined with Magnesium acetate tetrahydrate.
Eplerenone The risk or severity of dehydration can be increased when Eplerenone is combined with Magnesium acetate tetrahydrate.
Methazolamide The risk or severity of dehydration can be increased when Methazolamide is combined with Magnesium acetate tetrahydrate.
Mannitol The risk or severity of dehydration can be increased when Mannitol is combined with Magnesium acetate tetrahydrate.
Hydroflumethiazide The risk or severity of dehydration can be increased when Hydroflumethiazide is combined with Magnesium acetate tetrahydrate.
Indapamide The risk or severity of dehydration can be increased when Indapamide is combined with Magnesium acetate tetrahydrate.
Acetazolamide The risk or severity of dehydration can be increased when Acetazolamide is combined with Magnesium acetate tetrahydrate.
Conivaptan The risk or severity of dehydration can be increased when Conivaptan is combined with Magnesium acetate tetrahydrate.
Chlorothiazide The risk or severity of dehydration can be increased when Chlorothiazide is combined with Magnesium acetate tetrahydrate.
Bumetanide The risk or severity of dehydration can be increased when Bumetanide is combined with Magnesium acetate tetrahydrate.
Etacrynic acid The risk or severity of dehydration can be increased when Etacrynic acid is combined with Magnesium acetate tetrahydrate.
Zonisamide The risk or severity of dehydration can be increased when Zonisamide is combined with Magnesium acetate tetrahydrate.
Hydrochlorothiazide The risk or severity of dehydration can be increased when Hydrochlorothiazide is combined with Magnesium acetate tetrahydrate.
Trichlormethiazide The risk or severity of dehydration can be increased when Trichlormethiazide is combined with Magnesium acetate tetrahydrate.
Diclofenamide The risk or severity of dehydration can be increased when Diclofenamide is combined with Magnesium acetate tetrahydrate.
Polythiazide The risk or severity of dehydration can be increased when Polythiazide is combined with Magnesium acetate tetrahydrate.
Quinethazone The risk or severity of dehydration can be increased when Quinethazone is combined with Magnesium acetate tetrahydrate.
Drospirenone The risk or severity of dehydration can be increased when Drospirenone is combined with Magnesium acetate tetrahydrate.
Theobromine The risk or severity of dehydration can be increased when Theobromine is combined with Magnesium acetate tetrahydrate.
Piretanide The risk or severity of dehydration can be increased when Piretanide is combined with Magnesium acetate tetrahydrate.
Tienilic acid The risk or severity of dehydration can be increased when Tienilic acid is combined with Magnesium acetate tetrahydrate.
Ularitide The risk or severity of dehydration can be increased when Ularitide is combined with Magnesium acetate tetrahydrate.
Tolvaptan The risk or severity of dehydration can be increased when Tolvaptan is combined with Magnesium acetate tetrahydrate.
Indisulam The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium acetate tetrahydrate.
Azosemide The risk or severity of dehydration can be increased when Azosemide is combined with Magnesium acetate tetrahydrate.
Canrenoic acid The risk or severity of dehydration can be increased when Canrenoic acid is combined with Magnesium acetate tetrahydrate.
Potassium citrate The risk or severity of dehydration can be increased when Potassium citrate is combined with Magnesium acetate tetrahydrate.
Efonidipine The risk or severity of dehydration can be increased when Efonidipine is combined with Magnesium acetate tetrahydrate.
Mersalyl The risk or severity of dehydration can be increased when Mersalyl is combined with Magnesium acetate tetrahydrate.
Isosorbide The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium acetate tetrahydrate.
Canrenone The risk or severity of dehydration can be increased when Canrenone is combined with Magnesium acetate tetrahydrate.
Rolofylline The risk or severity of dehydration can be increased when Rolofylline is combined with Magnesium acetate tetrahydrate.
Spiradoline The risk or severity of dehydration can be increased when Spiradoline is combined with Magnesium acetate tetrahydrate.
Cicletanine The risk or severity of dehydration can be increased when Cicletanine is combined with Magnesium acetate tetrahydrate.
Meticrane The risk or severity of dehydration can be increased when Meticrane is combined with Magnesium acetate tetrahydrate.
Mefruside The risk or severity of dehydration can be increased when Mefruside is combined with Magnesium acetate tetrahydrate.
Mebutizide The risk or severity of dehydration can be increased when Mebutizide is combined with Magnesium acetate tetrahydrate.
Cyclopenthiazide The risk or severity of dehydration can be increased when Cyclopenthiazide is combined with Magnesium acetate tetrahydrate.
Clorexolone The risk or severity of dehydration can be increased when Clorexolone is combined with Magnesium acetate tetrahydrate.
Clofenamide The risk or severity of dehydration can be increased when Clofenamide is combined with Magnesium acetate tetrahydrate.
Fenquizone The risk or severity of dehydration can be increased when Fenquizone is combined with Magnesium acetate tetrahydrate.
Clopamide The risk or severity of dehydration can be increased when Clopamide is combined with Magnesium acetate tetrahydrate.
Muzolimine The risk or severity of dehydration can be increased when Muzolimine is combined with Magnesium acetate tetrahydrate.
Xipamide The risk or severity of dehydration can be increased when Xipamide is combined with Magnesium acetate tetrahydrate.
Epitizide The risk or severity of dehydration can be increased when Epitizide is combined with Magnesium acetate tetrahydrate.
Bromotheophylline The risk or severity of dehydration can be increased when Bromotheophylline is combined with Magnesium acetate tetrahydrate.
Potassium cation The risk or severity of dehydration can be increased when Potassium cation is combined with Magnesium acetate tetrahydrate.
Buthiazide The risk or severity of dehydration can be increased when Buthiazide is combined with Magnesium acetate tetrahydrate.
Tripamide The risk or severity of dehydration can be increased when Tripamide is combined with Magnesium acetate tetrahydrate.
Isradipine The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Isradipine.
Diltiazem The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Diltiazem.
Trimethadione The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Trimethadione.
Amlodipine The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Amlodipine.
Nimodipine The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Nimodipine.
Nisoldipine The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Nisoldipine.
Lercanidipine The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Lercanidipine.
Cinnarizine The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Cinnarizine.
Ethosuximide The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Ethosuximide.
Nicardipine The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Nicardipine.
Magnesium sulfate The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Magnesium sulfate.
Verapamil The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Verapamil.
Felodipine The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Felodipine.
Nitrendipine The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Nitrendipine.
Perhexiline The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Perhexiline.
Nifedipine The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Nifedipine.
Amiodarone The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Amiodarone.
Carvedilol The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Carvedilol.
Bepridil The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Bepridil.
Mibefradil The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Mibefradil.

Target Protein

Glutamate (NMDA) receptor GRIN1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 19621856
    Guerrera MP, Volpe SL, Mao JJ: Therapeutic uses of magnesium. Am Fam Physician. 2009 Jul 15;80(2):157-62.
  • PMID: 9677392
    Zimmermann G, Zhou D, Taussig R: Mutations uncover a role for two magnesium ions in the catalytic mechanism of adenylyl cyclase. J Biol Chem. 1998 Jul 31;273(31):19650-5.
  • PMID: 12663588
    Rodriguez-Moran M, Guerrero-Romero F: Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003 Apr;26(4):1147-52.
  • PMID: 23526071
    Jin K, Kim TH, Kim YH, Kim YW: Additional antihypertensive effect of magnesium supplementation with an angiotensin II receptor blocker in hypomagnesemic rats. Korean J Intern Med. 2013 Mar;28(2):197-205. doi: 10.3904/kjim.2013.28.2.197. Epub 2013 Feb 27.
  • PMID: 10480467
    Touyz RM, Milne FJ: Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats. Am J Hypertens. 1999 Aug;12(8 Pt 1):757-65.
  • PMID: 10930190
    Kh R, Khullar M, Kashyap M, Pandhi P, Uppal R: Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats. J Hypertens. 2000 Jul;18(7):919-26.
  • PMID: -
    Yu L, Xu L, Xu M, Wan B, Yu L, Huang Q.: Role of Mg2+ ions in protein kinase phosphorylation: insights from molecular dynamics simulations of ATP-kinase complexes Molecular Simulation. 2011 September 20;37(14):1143-1150.
Textbook
  • ISBN: 978-0-7020-3471-8
    29. (2012). In Rang and Dale's Pharmacology (7th ed., pp. 364). Edinburgh: Elsevier/Churchill Livingstone.
  • ISBN: 9780071624428
    46. (2011). In Goodman and Gilman's the pharmacological basis of therapeutics, Pharmacological basis of therapeutics (12th ed.). New York: McGraw-Hill.
  • ISBN: 9780729582261
    2. (2013). In Clinical naturopathic medicine (pp. 76-78). Elsevier Health Sciences, 2013.
  • ISBN: 9780080536279
    Civitelli, R., Ziambaras, K. and Leelawattana, R. (1997). 6. In Metabolic Bone Disease and Clinically Related Disorders (pp. 191-194). Academic Press.

Contoh Produk & Brand

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