Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the isosorbide mononitrate and isosorbide dinitrate forms, and is used for the prevention of angina. Refer to these drug entries for more information.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Dapoxetine | Dapoxetine may increase the orthostatic hypotensive and hypotensive activities of Isosorbide. |
| Riociguat | Isosorbide may increase the hypotensive activities of Riociguat. |
| Rosiglitazone | The risk or severity of adverse effects can be increased when Isosorbide is combined with Rosiglitazone. |
| Molsidomine | Molsidomine may increase the hypotensive activities of Isosorbide. |
| Tadalafil | The risk or severity of hypotension can be increased when Tadalafil is combined with Isosorbide. |
| Vardenafil | The risk or severity of hypotension can be increased when Vardenafil is combined with Isosorbide. |
| Dipyridamole | The risk or severity of hypotension can be increased when Dipyridamole is combined with Isosorbide. |
| Ibudilast | The risk or severity of hypotension can be increased when Ibudilast is combined with Isosorbide. |
| Avanafil | Avanafil may increase the hypotensive activities of Isosorbide. |
| Udenafil | The risk or severity of hypotension can be increased when Udenafil is combined with Isosorbide. |
| Doxofylline | The risk or severity of hypotension can be increased when Doxofylline is combined with Isosorbide. |
| Mirodenafil | The risk or severity of hypotension can be increased when Mirodenafil is combined with Isosorbide. |
| Fostamatinib | The risk or severity of hypotension can be increased when Fostamatinib is combined with Isosorbide. |
| Ethanol | Ethanol may increase the hypotensive and vasodilatory activities of Isosorbide. |
| Sodium phosphate, monobasic | Isosorbide may increase the nephrotoxic activities of Sodium phosphate, monobasic. |
| Acemetacin | The therapeutic efficacy of Isosorbide can be decreased when used in combination with Acemetacin. |
| Patent Blue | The therapeutic efficacy of Isosorbide can be decreased when used in combination with Patent Blue. |
| Lactulose | The risk or severity of dehydration can be increased when Isosorbide is combined with Lactulose. |
| Mannitol | The risk or severity of dehydration can be increased when Isosorbide is combined with Mannitol. |
| Lubiprostone | The risk or severity of dehydration can be increased when Isosorbide is combined with Lubiprostone. |
| Tegaserod | The risk or severity of dehydration can be increased when Isosorbide is combined with Tegaserod. |
| Magnesium oxide | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium oxide. |
| Magnesium cation | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium cation. |
| Sorbitol | The risk or severity of dehydration can be increased when Isosorbide is combined with Sorbitol. |
| Dantron | The risk or severity of dehydration can be increased when Isosorbide is combined with Dantron. |
| Oxyphenisatin | The risk or severity of dehydration can be increased when Isosorbide is combined with Oxyphenisatin. |
| Phenolphthalein | The risk or severity of dehydration can be increased when Isosorbide is combined with Phenolphthalein. |
| Emodin | The risk or severity of dehydration can be increased when Isosorbide is combined with Emodin. |
| Linaclotide | The risk or severity of dehydration can be increased when Isosorbide is combined with Linaclotide. |
| Bisacodyl | The risk or severity of dehydration can be increased when Isosorbide is combined with Bisacodyl. |
| Magnesium hydroxide | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium hydroxide. |
| Bisoxatin | The risk or severity of dehydration can be increased when Isosorbide is combined with Bisoxatin. |
| Picosulfuric acid | The risk or severity of dehydration can be increased when Isosorbide is combined with Picosulfuric acid. |
| Magnesium trisilicate | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium trisilicate. |
| Polyethylene glycol | The risk or severity of dehydration can be increased when Isosorbide is combined with Polyethylene glycol. |
| Polycarbophil | The risk or severity of dehydration can be increased when Isosorbide is combined with Polycarbophil. |
| Magnesium acetate tetrahydrate | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium acetate tetrahydrate. |
| Monopotassium phosphate | The risk or severity of dehydration can be increased when Isosorbide is combined with Monopotassium phosphate. |
| Dipotassium phosphate | The risk or severity of dehydration can be increased when Isosorbide is combined with Dipotassium phosphate. |
| Glycerin | The risk or severity of dehydration can be increased when Isosorbide is combined with Glycerin. |
| Sodium sulfate | The risk or severity of dehydration can be increased when Isosorbide is combined with Sodium sulfate. |
| Magnesium carbonate | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium carbonate. |
| Potassium lactate | The risk or severity of dehydration can be increased when Isosorbide is combined with Potassium lactate. |
| Sodium fluorophosphate | The risk or severity of dehydration can be increased when Isosorbide is combined with Sodium fluorophosphate. |
| Mineral oil | The risk or severity of dehydration can be increased when Isosorbide is combined with Mineral oil. |
| Carboxymethylcellulose | The risk or severity of dehydration can be increased when Isosorbide is combined with Carboxymethylcellulose. |
| Docusate | The risk or severity of dehydration can be increased when Isosorbide is combined with Docusate. |
| Plantago seed | The risk or severity of dehydration can be increased when Isosorbide is combined with Plantago seed. |
| Magnesium citrate | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium citrate. |
| Castor oil | The risk or severity of dehydration can be increased when Isosorbide is combined with Castor oil. |
| Magnesium glycinate | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium glycinate. |
| Methylcellulose | The risk or severity of dehydration can be increased when Isosorbide is combined with Methylcellulose. |
| Sennosides | The risk or severity of dehydration can be increased when Isosorbide is combined with Sennosides. |
| Lactitol | The risk or severity of dehydration can be increased when Isosorbide is combined with Lactitol. |
| Plecanatide | The risk or severity of dehydration can be increased when Isosorbide is combined with Plecanatide. |
| Gluconic Acid | The risk or severity of dehydration can be increased when Isosorbide is combined with Gluconic Acid. |
| Magnesium peroxide | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium peroxide. |
| Pentaerithrityl | The risk or severity of dehydration can be increased when Isosorbide is combined with Pentaerithrityl. |
| Sodium tartrate | The risk or severity of dehydration can be increased when Isosorbide is combined with Sodium tartrate. |
| Magnesium acetate | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium acetate. |
| Deacetylbisacodyl | The risk or severity of dehydration can be increased when Isosorbide is combined with Deacetylbisacodyl. |
| Sodium ascorbate | The risk or severity of dehydration can be increased when Isosorbide is combined with Sodium ascorbate. |
| Potassium sulfate | The risk or severity of dehydration can be increased when Isosorbide is combined with Potassium sulfate. |
| Sodium phosphate, dibasic | The risk or severity of dehydration can be increased when Isosorbide is combined with Sodium phosphate, dibasic. |
| Sodium phosphate, monobasic, unspecified form | The risk or severity of dehydration can be increased when Isosorbide is combined with Sodium phosphate, monobasic, unspecified form. |
| Sodium phosphate, dibasic, unspecified form | The risk or severity of dehydration can be increased when Isosorbide is combined with Sodium phosphate, dibasic, unspecified form. |
| Magnesium | The risk or severity of dehydration can be increased when Isosorbide is combined with Magnesium. |
| Sodium cation | The risk or severity of dehydration can be increased when Isosorbide is combined with Sodium cation. |
| Plantago ovata seed | The risk or severity of dehydration can be increased when Isosorbide is combined with Plantago ovata seed. |
| Oxyphenisatin acetate | The risk or severity of dehydration can be increased when Isosorbide is combined with Oxyphenisatin acetate. |
| Calcium polycarbophil | The risk or severity of dehydration can be increased when Isosorbide is combined with Calcium polycarbophil. |
| Konjac mannan | The risk or severity of dehydration can be increased when Isosorbide is combined with Konjac mannan. |
| Alloin | The risk or severity of dehydration can be increased when Isosorbide is combined with Alloin. |
| Frangula purshiana bark | The risk or severity of dehydration can be increased when Isosorbide is combined with Frangula purshiana bark. |
| Dehydrocholic acid | The risk or severity of dehydration can be increased when Isosorbide is combined with Dehydrocholic acid. |
| Sulfate ion | The risk or severity of dehydration can be increased when Isosorbide is combined with Sulfate ion. |
| Piperacillin | Isosorbide may increase the excretion rate of Piperacillin which could result in a lower serum level and potentially a reduction in efficacy. |
| Ampicillin | Isosorbide may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy. |
| Oxacillin | Isosorbide may increase the excretion rate of Oxacillin which could result in a lower serum level and potentially a reduction in efficacy. |
| Amoxicillin | Isosorbide may increase the excretion rate of Amoxicillin which could result in a lower serum level and potentially a reduction in efficacy. |
| Procaine benzylpenicillin | Isosorbide may increase the excretion rate of Procaine benzylpenicillin which could result in a lower serum level and potentially a reduction in efficacy. |
| Prucalopride | The risk or severity of dehydration can be increased when Isosorbide is combined with Prucalopride. |
| Diflunisal | Isosorbide may increase the excretion rate of Diflunisal which could result in a lower serum level and potentially a reduction in efficacy. |
| Ibuprofen | Isosorbide may increase the excretion rate of Ibuprofen which could result in a lower serum level and potentially a reduction in efficacy. |
| Naloxone | Isosorbide may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy. |
| Dexketoprofen | Isosorbide may increase the excretion rate of Dexketoprofen which could result in a lower serum level and potentially a reduction in efficacy. |
| Leuprolide | Isosorbide may increase the excretion rate of Leuprolide which could result in a lower serum level and potentially a reduction in efficacy. |
| Goserelin | Isosorbide may increase the excretion rate of Goserelin which could result in a lower serum level and potentially a reduction in efficacy. |
| Salmon calcitonin | Isosorbide may increase the excretion rate of Salmon calcitonin which could result in a lower serum level and potentially a reduction in efficacy. |
| Desmopressin | Isosorbide may increase the excretion rate of Desmopressin which could result in a lower serum level and potentially a reduction in efficacy. |
| Aldesleukin | Isosorbide may increase the excretion rate of Aldesleukin which could result in a lower serum level and potentially a reduction in efficacy. |
| Daptomycin | Isosorbide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. |
| Tositumomab | Isosorbide may increase the excretion rate of Tositumomab which could result in a lower serum level and potentially a reduction in efficacy. |
| Cyanocobalamin | Isosorbide may increase the excretion rate of Cyanocobalamin which could result in a lower serum level and potentially a reduction in efficacy. |
| Folic acid | Isosorbide may increase the excretion rate of Folic acid which could result in a lower serum level and potentially a reduction in efficacy. |
| Pyridoxine | Isosorbide may increase the excretion rate of Pyridoxine which could result in a lower serum level and potentially a reduction in efficacy. |
| Fluvoxamine | Isosorbide may increase the excretion rate of Fluvoxamine which could result in a lower serum level and potentially a reduction in efficacy. |
| Baclofen | Isosorbide may increase the excretion rate of Baclofen which could result in a lower serum level and potentially a reduction in efficacy. |
| Amphetamine | Isosorbide may increase the excretion rate of Amphetamine which could result in a lower serum level and potentially a reduction in efficacy. |
| Cevimeline | Isosorbide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy. |