Fluoride ion F-18

DB09398

small molecule approved

Deskripsi

Sodium Fluoride F 18 Injection is a positron emitting radiopharmaceutical, no-carrier added. It contains radioactive fluoride F 18 that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging and is administered by intravenous injection. Its primary indication is for bone imaging. Increased deposition around joints can occur in arthritis and following trauma and increased deposition in bone has been noted around fracture sites, in osteomyelitis, fibrous dysplasia, spondylitis tuberculosa, and Paget's disease. No adverse reactions have been reported.

Struktur Molekul 2D

Berat 18.0015

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) 110 min.

Volume Distribusi 0.5-0.7 L/Kg

Klirens (Clearance) Renal clearance for fluoride is 48-147 mL/min, depending upon urinary flow and pH.

Absorpsi

Following intravenous administration, Sodium Fluoride F 18 injection provides fluorine F 18 ions that rapidly equilibrate, primarily within the extracellular fluid space.

Metabolisme

First, the 18F- exchanges for an OH- ion on the surface of the hydroxyapatite matrix of bone and this is followed by migration of the 18F- into the crystalline matrix of the bone where it is retained until the bone is remodelled.

Rute Eliminasi

Fluorine F 18 ions are rapidly eliminated via the renal system. 20% or more of the fluorine F 18 ions are cleared from the body in the urine within the first 2 hours after intravenous administration.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Link

Contoh Produk & Brand

Produk: 26 • International brands: 0

Produk

Sodium Fluoride F 18

Injection • 200 mCi/1mL • Intravenous • US • Generic • Approved
Sodium Fluoride F 18

Injection • 200 mCi/1mL • Intravenous • US • Generic • Approved
Sodium Fluoride F 18

Injection • 91.5 mCi/1mL • Intravenous • US • Generic • Approved
Sodium Fluoride F 18

Injection, solution • 475 mCi/1mL • Intravenous • US
Sodium Fluoride F 18

Injection • 200 mCi/1mL • Intravenous • US • Generic • Approved
Sodium Fluoride F 18

Injection, solution • 200 mCi/1mL • Intravenous • US • Generic • Approved
Sodium Fluoride F 18

Injection • 200 mCi/1mL • Intravenous • US • Generic • Approved
Sodium Fluoride F 18

Injection • 200 mCi/1mL • Intravenous • US • Generic • Approved

Menampilkan 8 dari 26 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Peringatan Keamanan