Peringatan Keamanan

LD50 IP 325 mg/Kg (rat).
LD50 IV 1740 mg/Kg (mouse).
LD50 oral >5000 mg/Kg (rat).

Esterified estrogens

DB09381

small molecule approved

Deskripsi

Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of menopause such as hot flashes, vaginal dryness, vaginal burning or irritation, or other hormonal changes in the vagina. It is being also for the prevention and treatment of osteoporosis.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Half-life varies, it is in the range 1-2 hr.
Volume Distribusi The distribution of exogenous estrogens is similar to that of endogenous estrogens. Estrogens are widely distributed in the body and are generally found in higher concentration in the sex hormone target organs.
Klirens (Clearance) There is variation in the clearance rate depends on each estrogen individual: estradiol-17?: 580 L/day/m2 estrone: 4050 L/day/m2 estriol: 1110 L/day/m2

Absorpsi

Readily absorbed after oral administration. High concentrations of estrone are achieved with oral administration, whereas higher concentrations of estradiol are generally achieved after percutaneous absorption. Although vaginal products (such as gel, rings, etc.) are administered locally, they achieve high serum concentrations.

Metabolisme

Hepatic; partial metabolism via CYP3A4 enzymes; estradiol is reversibly converted to estrone and estriol; oral estradiol also undergoes enterohepatic recirculation by conjugation in the liver, followed by excretion of sulfate and glucuronide conjugates into the bile, then hydrolysis in the intestine and estrogen reabsorption. Sulfate conjugates are the primary form found in postmenopausal women.

Rute Eliminasi

Mainly urinary as estradiol, estrone, estriol, and their glucuronide and sulfate conjugates.

Interaksi Makanan

2 Data
  • 1. Avoid grapefruit products. Grapefruit inhibits CYP3A metabolism, which may increase the serum concentration of esterified estrogens.
  • 2. Avoid St. John's Wort. This herb induces CYP3A metabolism and may reduce serum levels of esterified estrogens.

Interaksi Obat

660 Data
Prasterone The risk or severity of adverse effects can be increased when Prasterone is combined with Esterified estrogens.
Exemestane The therapeutic efficacy of Exemestane can be decreased when used in combination with Esterified estrogens.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Esterified estrogens.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Esterified estrogens.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Esterified estrogens.
Lenalidomide Esterified estrogens may increase the thrombogenic activities of Lenalidomide.
Ospemifene The risk or severity of adverse effects can be increased when Esterified estrogens is combined with Ospemifene.
Ropinirole Esterified estrogens may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy.
Thalidomide Esterified estrogens may increase the thrombogenic activities of Thalidomide.
Cetuximab Esterified estrogens may increase the thrombogenic activities of Cetuximab.
Human immunoglobulin G Esterified estrogens may increase the thrombogenic activities of Human immunoglobulin G.
Omalizumab Esterified estrogens may increase the thrombogenic activities of Omalizumab.
Gemtuzumab ozogamicin Esterified estrogens may increase the thrombogenic activities of Gemtuzumab ozogamicin.
Indium In-111 satumomab pendetide Esterified estrogens may increase the thrombogenic activities of Indium In-111 satumomab pendetide.
Trastuzumab Esterified estrogens may increase the thrombogenic activities of Trastuzumab.
Rituximab Esterified estrogens may increase the thrombogenic activities of Rituximab.
Basiliximab Esterified estrogens may increase the thrombogenic activities of Basiliximab.
Muromonab Esterified estrogens may increase the thrombogenic activities of Muromonab.
Digoxin Immune Fab (Ovine) Esterified estrogens may increase the thrombogenic activities of Digoxin Immune Fab (Ovine).
Ibritumomab tiuxetan Esterified estrogens may increase the thrombogenic activities of Ibritumomab tiuxetan.
Tositumomab Esterified estrogens may increase the thrombogenic activities of Tositumomab.
Alemtuzumab Esterified estrogens may increase the thrombogenic activities of Alemtuzumab.
Capromab pendetide Esterified estrogens may increase the thrombogenic activities of Capromab pendetide.
Efalizumab Esterified estrogens may increase the thrombogenic activities of Efalizumab.
Antithymocyte immunoglobulin (rabbit) Esterified estrogens may increase the thrombogenic activities of Antithymocyte immunoglobulin (rabbit).
Natalizumab Esterified estrogens may increase the thrombogenic activities of Natalizumab.
Palivizumab Esterified estrogens may increase the thrombogenic activities of Palivizumab.
Daclizumab Esterified estrogens may increase the thrombogenic activities of Daclizumab.
Bevacizumab Esterified estrogens may increase the thrombogenic activities of Bevacizumab.
Technetium Tc-99m arcitumomab Esterified estrogens may increase the thrombogenic activities of Technetium Tc-99m arcitumomab.
Eculizumab Esterified estrogens may increase the thrombogenic activities of Eculizumab.
Panitumumab Esterified estrogens may increase the thrombogenic activities of Panitumumab.
Ranibizumab Esterified estrogens may increase the thrombogenic activities of Ranibizumab.
Galiximab Esterified estrogens may increase the thrombogenic activities of Galiximab.
Pexelizumab Esterified estrogens may increase the thrombogenic activities of Pexelizumab.
Epratuzumab Esterified estrogens may increase the thrombogenic activities of Epratuzumab.
Bectumomab Esterified estrogens may increase the thrombogenic activities of Bectumomab.
Oregovomab Esterified estrogens may increase the thrombogenic activities of Oregovomab.
IGN311 Esterified estrogens may increase the thrombogenic activities of IGN311.
Adecatumumab Esterified estrogens may increase the thrombogenic activities of Adecatumumab.
Labetuzumab Esterified estrogens may increase the thrombogenic activities of Labetuzumab.
Matuzumab Esterified estrogens may increase the thrombogenic activities of Matuzumab.
Fontolizumab Esterified estrogens may increase the thrombogenic activities of Fontolizumab.
Bavituximab Esterified estrogens may increase the thrombogenic activities of Bavituximab.
CR002 Esterified estrogens may increase the thrombogenic activities of CR002.
Rozrolimupab Esterified estrogens may increase the thrombogenic activities of Rozrolimupab.
Girentuximab Esterified estrogens may increase the thrombogenic activities of Girentuximab.
Obiltoxaximab Esterified estrogens may increase the thrombogenic activities of Obiltoxaximab.
XTL-001 Esterified estrogens may increase the thrombogenic activities of XTL-001.
NAV 1800 Esterified estrogens may increase the thrombogenic activities of NAV 1800.
Briakinumab Esterified estrogens may increase the thrombogenic activities of Briakinumab.
Otelixizumab Esterified estrogens may increase the thrombogenic activities of Otelixizumab.
AMG 108 Esterified estrogens may increase the thrombogenic activities of AMG 108.
Iratumumab Esterified estrogens may increase the thrombogenic activities of Iratumumab.
Enokizumab Esterified estrogens may increase the thrombogenic activities of Enokizumab.
Ramucirumab Esterified estrogens may increase the thrombogenic activities of Ramucirumab.
Farletuzumab Esterified estrogens may increase the thrombogenic activities of Farletuzumab.
Veltuzumab Esterified estrogens may increase the thrombogenic activities of Veltuzumab.
Ustekinumab Esterified estrogens may increase the thrombogenic activities of Ustekinumab.
PRO-542 Esterified estrogens may increase the thrombogenic activities of PRO-542.
TNX-901 Esterified estrogens may increase the thrombogenic activities of TNX-901.
Inotuzumab ozogamicin Esterified estrogens may increase the thrombogenic activities of Inotuzumab ozogamicin.
RI 624 Esterified estrogens may increase the thrombogenic activities of RI 624.
Stamulumab Esterified estrogens may increase the thrombogenic activities of MYO-029.
CT-011 Esterified estrogens may increase the thrombogenic activities of CT-011.
Leronlimab Esterified estrogens may increase the thrombogenic activities of Leronlimab.
Glembatumumab vedotin Esterified estrogens may increase the thrombogenic activities of Glembatumumab vedotin.
Olaratumab Esterified estrogens may increase the thrombogenic activities of Olaratumab.
IPH 2101 Esterified estrogens may increase the thrombogenic activities of IPH 2101.
TB-402 Esterified estrogens may increase the thrombogenic activities of TB-402.
Caplacizumab Esterified estrogens may increase the thrombogenic activities of Caplacizumab.
IMC-1C11 Esterified estrogens may increase the thrombogenic activities of IMC-1C11.
Eldelumab Esterified estrogens may increase the thrombogenic activities of Eldelumab.
Lumiliximab Esterified estrogens may increase the thrombogenic activities of Lumiliximab.
Ipilimumab Esterified estrogens may increase the thrombogenic activities of Ipilimumab.
Nimotuzumab Esterified estrogens may increase the thrombogenic activities of Nimotuzumab.
Clenoliximab Esterified estrogens may increase the thrombogenic activities of Clenoliximab.
BIIB015 Esterified estrogens may increase the thrombogenic activities of BIIB015.
Sonepcizumab Esterified estrogens may increase the thrombogenic activities of Sonepcizumab.
Motavizumab Esterified estrogens may increase the thrombogenic activities of Motavizumab.
Elotuzumab Esterified estrogens may increase the thrombogenic activities of Elotuzumab.
Carotuximab Esterified estrogens may increase the thrombogenic activities of Carotuximab.
XmAb 2513 Esterified estrogens may increase the thrombogenic activities of XmAb 2513.
Lucatumumab Esterified estrogens may increase the thrombogenic activities of Lucatumumab.
Pertuzumab Esterified estrogens may increase the thrombogenic activities of Pertuzumab.
Siplizumab Esterified estrogens may increase the thrombogenic activities of Siplizumab.
Apolizumab Esterified estrogens may increase the thrombogenic activities of Apolizumab.
Sibrotuzumab Esterified estrogens may increase the thrombogenic activities of Sibrotuzumab.
Bivatuzumab Esterified estrogens may increase the thrombogenic activities of Bivatuzumab.
Lerdelimumab Esterified estrogens may increase the thrombogenic activities of Lerdelimumab.
Lexatumumab Esterified estrogens may increase the thrombogenic activities of Lexatumumab.
Reslizumab Esterified estrogens may increase the thrombogenic activities of Reslizumab.
Teplizumab Esterified estrogens may increase the thrombogenic activities of Teplizumab.
Catumaxomab Esterified estrogens may increase the thrombogenic activities of Catumaxomab.
Mepolizumab Esterified estrogens may increase the thrombogenic activities of Mepolizumab.
Denosumab Esterified estrogens may increase the thrombogenic activities of Denosumab.
Volociximab Esterified estrogens may increase the thrombogenic activities of Volociximab.
Ofatumumab Esterified estrogens may increase the thrombogenic activities of Ofatumumab.
Belimumab Esterified estrogens may increase the thrombogenic activities of Belimumab.
Raxibacumab Esterified estrogens may increase the thrombogenic activities of Raxibacumab.

Referensi & Sumber

Contoh Produk & Brand

Produk: 53 • International brands: 4
Produk
  • Covaryx
    Tablet, coated • - • Oral • US
  • Covaryx Hs
    Tablet, coated • - • Oral • US
  • Eemt
    Tablet, coated • - • Oral • US
  • Eemt H.S.
    Tablet, coated • - • Oral • US
  • Eemt Hs
    Tablet, coated • - • Oral • US
  • Essian
    Tablet • - • Oral • US
  • Essian H.S.
    Tablet • - • Oral • US
  • Esterified Estrogen and Methyltestosterone
    Tablet • - • Oral • US
Menampilkan 8 dari 53 produk.
International Brands
  • Amnestrogen
  • Estratab
  • Evex
  • Femogen

Sekuens Gen/Protein (FASTA)

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