Peringatan Keamanan

In preclinical studies performed in rodents, the LD50 after oral or intravenous administration was 2 g/kg and 8 g/kg respectively.^L1705

Acetrizoic acid

DB09347

small molecule withdrawn

Deskripsi

Acetrizoic acid presents the molecular formula of 3-acetamidol-2,4,6-triiodobenzoic acid^L1702 and it is the first monomeric ionic compound used as an X-ray contrast agent.^A32135 It was first synthesized by Wallingford in 1953^A32136 and it was filled in the FDA by the Johnson & Johnson subsidiary, Cilag Chemie AG, on February 8th, 1978.^L1704 Acetrizoic acid presents, in the FDA records, a category of drug substance with an inactive status.^L1703

Struktur Molekul 2D

Berat 556.864

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) When water-soluble contrast agents, such as acetrizoic acid, are administered, it is reported a half-life of approximate 4 hours.[L1708]

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

After intravenous administration, acetrizoic acid gets largely distributed in the extracellular fluid space.T131 Radiographic agents like acetrizoic agents present variations in the plasma concentration depending on the dose and injection rate. After 5 minutes of administration, about 80% of the administered dose will stay outside of the intravascular compartment. There are some exceptions to the diffusion, such as the brain, neural tissue and testes where the tight junctions do not allow extravascularization.^L1707

Metabolisme

The majority of the administered dose of acetrizoic acid remains unchanged.T131

Rute Eliminasi

After intravenous administration, acetrizoic acid is mainly excreted unchanged by the kidney.T131 The elimination pathway is handled by a glomerular filtration and concentration by tubular resorption of water. The excreted dose is of about 83% of the administered dose after 3 hours and of about 100% at 24 hours.^L1707

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 20641970
Cheng KT: N,N -Bis(2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)-glycolamidol-2,4,6-triiodoisopht halamide .
PMID: 13108780
WALLINGFORD VH: The development of organic iodine compounds as x-ray contrast media. J Am Pharm Assoc Am Pharm Assoc. 1953 Dec;42(12):721-8.

Textbook

Swanson D., et al. (1990). Pharmaceuticals in medical imaging. McGraw-Hill Professional.
Dawson P. (1999). Textbook of contrast media. Oxford.

Link

Contoh Produk & Brand

Produk: 0 • International brands: 0

Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.