Peringatan Keamanan

Data not available.

Ammonia N-13

DB09326

small molecule approved

Deskripsi

Ammonia N 13 Injection, USP is a positron emitting radiopharmaceutical that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging. The active ingredient, 13N ammonia, has the molecular formula of 13NH3 with a molecular weight of 16.02.
Ammonia N 13 Injection, USP is used for imaging of the myocardium under rest or pharmacologic stress conditions to evaluate myocardial perfusion in patients with suspected or existing coronary artery disease.

Struktur Molekul 2D

Berat 16.03

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.84 minutes.

Volume Distribusi 0.8 ml/g.

Klirens (Clearance) The radioactivity cleared from the blood very rapidly with 85% clearance in the first minute.

Absorpsi

Following intravenous injection, 13N-ammonia is cleared rapidly from the blood with a biologic half-life of about 2.84 minutes (effective half-life of about 2.2 minutes). In the myocardium, its biologic half-life has been estimated to be less than 2 minutes (effective half-life less than 1.67 minutes).

Metabolisme

Ammonia N 13 undergoes a five-enzyme step metabolism in the liver to yield urea N 13 (the main circulating metabolite). It is also metabolized to glutamine N 13 (the main metabolite in tissues) by glutamine synthesis in the skeletal muscles, liver, brain, myocardium, and other organs. Other metabolites of ammonia N 13 include small amounts of N 13 amino acid anions (acidic amino acids) in the forms of glutamate N 13 or aspartate N 13.

Rute Eliminasi

Urinary excretion mainly as urea N 13.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Link

Contoh Produk & Brand

Produk: 32 • International brands: 0

Produk

Ammonia N 13

Injection • 37.5 mCi/1mL • Intravenous • US • Generic • Approved
Ammonia N 13

Injection • 37.5 mCi/1mL • Intravenous • US • Generic • Approved
Ammonia N 13

Injection • 37.5 mCi/1mL • Intravenous • US • Generic • Approved
Ammonia N 13

Injection, solution • 37.5 mCi/1mL • Intravenous • US • Generic • Approved
Ammonia N 13

Injection • 37.5 mCi/1mL • Intravenous • US • Generic • Approved
Ammonia N 13

Injection • 37.5 mCi/1mL • Intravenous • US • Generic • Approved
Ammonia N 13

Injection • 260 mCi/1mL • Intravenous • US • Generic • Approved
Ammonia N 13

Injection • 37.5 mCi/1mL • Intravenous • US • Generic • Approved

Menampilkan 8 dari 32 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.