Peringatan Keamanan

The oral LD₅₀ of sulbactam sodium is >4000 mg/kg in rats and >10,000 mg/kg in mice. The intravenous LD₅₀ of sulbactam sodium is 4582 mg/kg in rats and 3604 mg/kg in mice.^L50136

There is no information on the clinical signs and symptoms associated with a sulbactam overdose. Neurological adverse reactions, including convulsions, may occur. While sulbactam is removable by hemodialysis, there is limited clinical information regarding the use of hemodialysis to treat overdosage.^L47336

Sulbactam

DB09324

small molecule approved

Deskripsi

Sulbactam is a beta (?)-lactamase inhibitor and a derivative of the basic penicillin nucleus.^L50131 When given in combination with ?-lactam antibiotics, sulbactam produces a synergistic effect as it blocks the enzyme responsible for drug resistance by hydrolyzing ?-lactams.^A263296

Struktur Molekul 2D

Berat 233.242

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) In healthy volunteers, the half-life is approximately one hour.[L50131]

Volume Distribusi The steady-state volumes of distribution range from 12.2 to 16.3?L. Sulbactam exhibits extensive distribution in extracellular fluids and tissues.[A263296] Penetration of sulbactam into cerebrospinal fluid is enhanced in the presence of inflamed meninges.[L50131]

Klirens (Clearance) Eenal clearance is approximately 12 L/h following infusion over 15 to 30 minutes.[A263291]

Absorpsi

Sulbactam is poorly absorbed after oral administration.^A263291 Peak serum concentrations of ampicillin and sulbactam are reached following a 15-minute intravenous infusion. After the intravenous administration of 2000 mg of ampicillin plus 1000 mg sulbactam, peak sulbactam serum levels corresponded to 48 to 88 mcg/mL. After the intravenous administration of 1000 mg ampicillin plus 500 mg sulbactam, peak sulbactam serum levels corresponded to 21 to 40 mcg/mL. After an intramuscular injection of 1000 mg ampicillin plus 500 mg sulbactam, peak sulbactam serum levels ranged from 6 to 24 mcg/mL.^L50131

Metabolisme

Metabolism of sulbactam has not been characterized.^A263291

Rute Eliminasi

When given in combination with ampicillin in individuals with normal renal function, approximately 75 to 85% of the drug is excreted unchanged in the urine during the first eight hours after administration.^L50131

Interaksi Obat

767 Data

Cyclosporine	Cyclosporine may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Icosapent	Icosapent may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefotiam	Cefotiam may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Mesalazine	Mesalazine may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefmenoxime	Cefmenoxime may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefmetazole	Cefmetazole may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Pamidronic acid	Pamidronic acid may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Tenofovir disoproxil	Tenofovir disoproxil may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Indomethacin	Indomethacin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cidofovir	Cidofovir may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefpiramide	Cefpiramide may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Ceftazidime	Ceftazidime may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Loracarbef	Loracarbef may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefalotin	Cefalotin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Nabumetone	Nabumetone may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Ketorolac	Ketorolac may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Tenoxicam	Tenoxicam may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Celecoxib	Celecoxib may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefotaxime	Cefotaxime may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Tolmetin	Tolmetin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Foscarnet	Foscarnet may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Rofecoxib	Rofecoxib may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Piroxicam	Piroxicam may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Methotrexate	Methotrexate may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cephalexin	Cephalexin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Fenoprofen	Fenoprofen may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Valaciclovir	Valaciclovir may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Valdecoxib	Valdecoxib may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Diclofenac	Diclofenac may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Sulindac	Sulindac may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Bacitracin	Bacitracin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Amphotericin B	Amphotericin B may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cephaloglycin	Cephaloglycin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Flurbiprofen	Flurbiprofen may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Adefovir dipivoxil	Adefovir dipivoxil may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Pentamidine	Pentamidine may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Etodolac	Etodolac may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Mefenamic acid	Mefenamic acid may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Acyclovir	Acyclovir may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Naproxen	Naproxen may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Sulfasalazine	Sulfasalazine may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Phenylbutazone	Phenylbutazone may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Meloxicam	Meloxicam may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Carprofen	Carprofen may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefaclor	Cefaclor may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Diflunisal	Diflunisal may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Tacrolimus	Tacrolimus may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Ceforanide	Ceforanide may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Salicylic acid	Salicylic acid may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Meclofenamic acid	Meclofenamic acid may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Acetylsalicylic acid	Acetylsalicylic acid may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Carboplatin	Carboplatin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Oxaprozin	Oxaprozin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Ketoprofen	Ketoprofen may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Balsalazide	Balsalazide may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Ibuprofen	Ibuprofen may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefditoren	Cefditoren may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Atazanavir	Atazanavir may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Colistimethate	Colistimethate may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefuroxime	Cefuroxime may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefapirin	Cefapirin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefadroxil	Cefadroxil may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefprozil	Cefprozil may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Olsalazine	Olsalazine may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Lumiracoxib	Lumiracoxib may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefamandole	Cefamandole may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefazolin	Cefazolin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefonicid	Cefonicid may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefotetan	Cefotetan may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefoxitin	Cefoxitin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Ceftizoxime	Ceftizoxime may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefradine	Cefradine may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Magnesium salicylate	Magnesium salicylate may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Salsalate	Salsalate may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Choline magnesium trisalicylate	Choline magnesium trisalicylate may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefepime	Cefepime may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefacetrile	Cefacetrile may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Ceftibuten	Ceftibuten may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cefpodoxime	Cefpodoxime may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Antrafenine	Antrafenine may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Aminophenazone	Aminophenazone may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Antipyrine	Antipyrine may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Tiaprofenic acid	Tiaprofenic acid may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Lopinavir	Lopinavir may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Etoricoxib	Etoricoxib may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Hydrolyzed Cephalothin	Hydrolyzed Cephalothin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cephalothin Group	Cephalothin Group may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Oxyphenbutazone	Oxyphenbutazone may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Latamoxef	Latamoxef may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Nimesulide	Nimesulide may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Benoxaprofen	Benoxaprofen may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Metamizole	Metamizole may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Zomepirac	Zomepirac may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Ceftobiprole	Ceftobiprole may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Cimicoxib	Cimicoxib may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Ceftaroline fosamil	Ceftaroline fosamil may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Lornoxicam	Lornoxicam may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Aceclofenac	Aceclofenac may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Zaltoprofen	Zaltoprofen may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Azapropazone	Azapropazone may decrease the excretion rate of Sulbactam which could result in a higher serum level.

Target Protein

Beta-lactamase blaZ

Referensi & Sumber

Artikel (PubMed)

PMID: 3038500
Campoli-Richards DM, Brogden RN: Sulbactam/ampicillin. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic use. Drugs. 1987 Jun;33(6):577-609. doi: 10.2165/00003495-198733060-00003.
PMID: 30252373
Peechakara BV, Gupta M: Ampicillin/Sulbactam. .
PMID: 31261671
Stover KR, Barber KE, Wagner JL: Allergic Reactions and Cross-Reactivity Potential with Beta-Lactamase Inhibitors. Pharmacy (Basel). 2019 Jun 28;7(3). pii: pharmacy7030077. doi: 10.3390/pharmacy7030077.
PMID: 3278833
Noguchi JK, Gill MA: Sulbactam: a beta-lactamase inhibitor. Clin Pharm. 1988 Jan;7(1):37-51.

Link

Contoh Produk & Brand

Produk: 100 • International brands: 0

Produk

Ampicillin and Sulbactam

Injection, powder, for solution • - • Intravenous • US • Generic • Approved
Ampicillin and Sulbactam

Injection, powder, for solution • - • Intravenous • US • Generic • Approved
Ampicillin and Sulbactam

Injection, powder, for solution • - • Intramuscular; Intravenous • US • Generic • Approved
Ampicillin and Sulbactam

Injection, powder, for solution • - • Intramuscular; Intravenous • US • Generic • Approved
Ampicillin and Sulbactam

Injection, powder, for solution • - • Intravenous • US • Generic • Approved
Ampicillin and Sulbactam

Injection, powder, for solution • - • Intramuscular; Intravenous • US • Generic • Approved
Ampicillin and Sulbactam

Injection, powder, for solution • - • Intramuscular; Intravenous • US • Generic • Approved
Ampicillin and Sulbactam

Injection, powder, for solution • - • Intramuscular; Intravenous • US • Generic • Approved

Menampilkan 8 dari 100 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.