Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Irinotecan | The risk or severity of neutropenia can be increased when Silibinin is combined with Irinotecan. |
| Aspartame | The excretion of Silibinin can be decreased when combined with Aspartame. |
| Pravastatin | The excretion of Silibinin can be decreased when combined with Pravastatin. |
| Pantoprazole | The excretion of Silibinin can be decreased when combined with Pantoprazole. |
| Cefotiam | The excretion of Silibinin can be decreased when combined with Cefotiam. |
| Conjugated estrogens | The excretion of Silibinin can be decreased when combined with Conjugated estrogens. |
| Aminohippuric acid | The excretion of Silibinin can be decreased when combined with Aminohippuric acid. |
| Lansoprazole | The excretion of Silibinin can be decreased when combined with Lansoprazole. |
| Cefalotin | The excretion of Silibinin can be decreased when combined with Cefalotin. |
| Tenoxicam | The excretion of Silibinin can be decreased when combined with Tenoxicam. |
| Cefotaxime | The excretion of Silibinin can be decreased when combined with Cefotaxime. |
| Cimetidine | The excretion of Silibinin can be decreased when combined with Cimetidine. |
| Guanidine | The excretion of Silibinin can be decreased when combined with Guanidine. |
| Piroxicam | The excretion of Silibinin can be decreased when combined with Piroxicam. |
| Methotrexate | The excretion of Silibinin can be decreased when combined with Methotrexate. |
| Cephalexin | The excretion of Silibinin can be decreased when combined with Cephalexin. |
| Enalapril | The excretion of Silibinin can be decreased when combined with Enalapril. |
| Oxytetracycline | The excretion of Silibinin can be decreased when combined with Oxytetracycline. |
| Leucovorin | The excretion of Silibinin can be decreased when combined with Leucovorin. |
| Esomeprazole | The excretion of Silibinin can be decreased when combined with Esomeprazole. |
| Tetracycline | The excretion of Silibinin can be decreased when combined with Tetracycline. |
| Acyclovir | The excretion of Silibinin can be decreased when combined with Acyclovir. |
| Phenylbutazone | The excretion of Silibinin can be decreased when combined with Phenylbutazone. |
| Cefaclor | The excretion of Silibinin can be decreased when combined with Cefaclor. |
| Bumetanide | The excretion of Silibinin can be decreased when combined with Bumetanide. |
| Quinidine | The excretion of Silibinin can be decreased when combined with Quinidine. |
| Dinoprostone | The excretion of Silibinin can be decreased when combined with Dinoprostone. |
| Famotidine | The excretion of Silibinin can be decreased when combined with Famotidine. |
| Salicylic acid | The excretion of Silibinin can be decreased when combined with Salicylic acid. |
| Acetylsalicylic acid | The excretion of Silibinin can be decreased when combined with Acetylsalicylic acid. |
| Ganciclovir | The excretion of Silibinin can be decreased when combined with Ganciclovir. |
| Minocycline | The excretion of Silibinin can be decreased when combined with Minocycline. |
| Probenecid | The excretion of Silibinin can be decreased when combined with Probenecid. |
| Mercaptopurine | The excretion of Silibinin can be decreased when combined with Mercaptopurine. |
| Novobiocin | The excretion of Silibinin can be decreased when combined with Novobiocin. |
| Benzylpenicillin | The excretion of Silibinin can be decreased when combined with Benzylpenicillin. |
| Melatonin | The excretion of Silibinin can be decreased when combined with Melatonin. |
| Ouabain | The excretion of Silibinin can be decreased when combined with Ouabain. |
| Rosuvastatin | The excretion of Silibinin can be decreased when combined with Rosuvastatin. |
| Cefadroxil | The excretion of Silibinin can be decreased when combined with Cefadroxil. |
| Ceftriaxone | The excretion of Silibinin can be decreased when combined with Ceftriaxone. |
| Cefamandole | The excretion of Silibinin can be decreased when combined with Cefamandole. |
| Cefazolin | The excretion of Silibinin can be decreased when combined with Cefazolin. |
| Cefoperazone | The excretion of Silibinin can be decreased when combined with Cefoperazone. |
| Ceftizoxime | The excretion of Silibinin can be decreased when combined with Ceftizoxime. |
| Cefacetrile | The excretion of Silibinin can be decreased when combined with Cefacetrile. |
| Ceftibuten | The excretion of Silibinin can be decreased when combined with Ceftibuten. |
| Liotrix | The excretion of Silibinin can be decreased when combined with Liotrix. |
| Cilastatin | The excretion of Silibinin can be decreased when combined with Cilastatin. |
| Tazobactam | The excretion of Silibinin can be decreased when combined with Tazobactam. |
| trans-2-hydroxycinnamic acid | The excretion of Silibinin can be decreased when combined with trans-2-hydroxycinnamic acid. |
| Topiroxostat | The excretion of Silibinin can be decreased when combined with Topiroxostat. |
| Cholic Acid | The excretion of Silibinin can be decreased when combined with Cholic Acid. |
| Glutaric Acid | The excretion of Silibinin can be decreased when combined with Glutaric Acid. |
| Benzoic acid | The excretion of Silibinin can be decreased when combined with Benzoic acid. |
| Taurocholic acid | The excretion of Silibinin can be decreased when combined with Taurocholic acid. |
| Caprylic acid | The excretion of Silibinin can be decreased when combined with Caprylic acid. |
| Ataluren | The excretion of Silibinin can be decreased when combined with Ataluren. |
| Teriflunomide | The excretion of Silibinin can be decreased when combined with Teriflunomide. |
| Dabrafenib | The excretion of Silibinin can be decreased when combined with Dabrafenib. |
| Cefaloridine | The excretion of Silibinin can be decreased when combined with Cefaloridine. |
| Lenvatinib | The excretion of Silibinin can be decreased when combined with Lenvatinib. |
| Cabotegravir | The excretion of Silibinin can be decreased when combined with Cabotegravir. |
| Apalutamide | The excretion of Silibinin can be decreased when combined with Apalutamide. |
| Pradigastat | The excretion of Silibinin can be decreased when combined with Pradigastat. |
| Dronedarone | The excretion of Silibinin can be decreased when combined with Dronedarone. |
| Favipiravir | The excretion of Silibinin can be decreased when combined with Favipiravir. |
| Tafamidis | The excretion of Silibinin can be decreased when combined with Tafamidis. |
| Linezolid | The excretion of Silibinin can be decreased when combined with Linezolid. |
| Eluxadoline | The serum concentration of Eluxadoline can be increased when it is combined with Silibinin. |
| Valsartan | The excretion of Valsartan can be decreased when combined with Silibinin. |
| Erythromycin | The excretion of Erythromycin can be decreased when combined with Silibinin. |
| Torasemide | The excretion of Torasemide can be decreased when combined with Silibinin. |
| Digoxin | The excretion of Digoxin can be decreased when combined with Silibinin. |
| Caspofungin | The excretion of Caspofungin can be decreased when combined with Silibinin. |
| Bosentan | The excretion of Bosentan can be decreased when combined with Silibinin. |
| Sumatriptan | The excretion of Sumatriptan can be decreased when combined with Silibinin. |
| Penicillamine | The excretion of Penicillamine can be decreased when combined with Silibinin. |
| Repaglinide | The excretion of Repaglinide can be decreased when combined with Silibinin. |
| Fexofenadine | The excretion of Fexofenadine can be decreased when combined with Silibinin. |
| Atrasentan | The excretion of Atrasentan can be decreased when combined with Silibinin. |
| Simeprevir | The excretion of Simeprevir can be decreased when combined with Silibinin. |
| Ambrisentan | The excretion of Ambrisentan can be decreased when combined with Silibinin. |
| Gimatecan | The excretion of Gimatecan can be decreased when combined with Silibinin. |
| Temocapril | The excretion of Temocapril can be decreased when combined with Silibinin. |
| Cholecystokinin | The excretion of Cholecystokinin can be decreased when combined with Silibinin. |
| Gadoxetic acid | The excretion of Gadoxetic acid can be decreased when combined with Silibinin. |
| Technetium Tc-99m mebrofenin | The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Silibinin. |
| Fimasartan | The excretion of Fimasartan can be decreased when combined with Silibinin. |
| Paritaprevir | The excretion of Paritaprevir can be decreased when combined with Silibinin. |
| Selexipag | The excretion of Selexipag can be decreased when combined with Silibinin. |
| Grazoprevir | The excretion of Grazoprevir can be decreased when combined with Silibinin. |
| Asunaprevir | The excretion of Asunaprevir can be decreased when combined with Silibinin. |
| Voxilaprevir | The excretion of Voxilaprevir can be decreased when combined with Silibinin. |
| Levosalbutamol | The excretion of Levosalbutamol can be decreased when combined with Silibinin. |
| Glecaprevir | The excretion of Glecaprevir can be decreased when combined with Silibinin. |
| Belantamab mafodotin | The excretion of Belantamab mafodotin can be decreased when combined with Silibinin. |
| Testosterone | The excretion of Silibinin can be increased when combined with Testosterone. |
| Methyltestosterone | The excretion of Silibinin can be increased when combined with Methyltestosterone. |
| Testosterone cypionate | The excretion of Silibinin can be increased when combined with Testosterone cypionate. |