Peringatan Keamanan

Adverse reactions that have been reported with doses of sodium iodide I-131 used in the treatment of benign disease include sialadenitis, chest pain, tachycardia, iododerma, itching skin, rash, hives, hypothyroidism, hyperthyroidism, thyrotoxic crisis, hypoparathyroidism, and local swelling.
Adverse reactions that have been reported with doses of sodium iodide I-131 used in the treatment of malignant disease include radiation sickness, bone marrow depression, anemia, leucopenia, thrombocytopenia, blood dyscrasia, leukemia, solid cancers, lacrimal gland dysfunction, salivary gland dysfunction, congenital hypothyroidism, chromosomal abnormalities, cerebral edema, radiation pneumonitis, and pulmonary fibrosis.

Iodide I-131

DB09293

small molecule approved investigational

Deskripsi

Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation dose is via gamma radiation, while the other 90% (beta radiation) causes tissue damage without contributing to any ability to see or image the isotope. Low levels of beta radiation are also known for causing cancer as this dose is highly mutagenic. For this reason, less toxic iodine isotopes such as I-123 are more frequently used in nuclear imaging, while I-131 is reserved for its tissue destroying effects. Because the thyroid gland naturally takes up iodine from the body, therapeutic methods using radioisotopes can take advantage of this mechanism for localization of drug to the site of malignancy.

Therapeutic solutions of Sodium Iodide-131 are indicated for the treatment of hyperthyroidism and thyroid carcinomas that take up iodine. Palliative effects may be observed in patients with advanced thyroid malignancy if the metastatic lesions take up iodine. It is also indicated for use in performance of the radioactive iodide (RAI) uptake test to evaluate thyroid function.

Struktur Molekul 2D

Berat 130.9067

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Iodine I-131 decays by beta emission and associated gamma emission with a physical half-life of 8.04 days.

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

After oral administration, sodium iodide I-131 is absorbed rapidly from the upper gastrointestinal tract (90% in 60 minutes). Following absorption, the iodide is primarily distributed within the extra-cellular fluid of the body. It is trapped by the thyroid. The thyroid uptake of iodide is usually increased in hyperthyroidism and in goiter with impaired hormone synthesis, decreased in hypothyroidism, and normal to decreased in hypothyroidism receiving iodine. It should be noted that the uptake of radioactive iodide is a function of stable iodide concentration in the serum and the functional state of the thyroid.

Metabolisme

Trapped iodide is oxidized to iodine and organically incorporated so rapidly that the iodide trap of the thyroid contains less than 0.2 % free iodide in comparison to the organically bound iodine. This process results in further concentration of iodine in the thyroid gland to about 500 times that in the blood.

Rute Eliminasi

Sodium Iodide I-131 is excreted by the kidneys. The normal range of urinary excretion is 37 to 75 % of the administered dose, varying with the thyroid and renal function of the patient.

Interaksi Makanan

3 Data

1. Drink plenty of fluids.
2. Limit iodine intake. Consume a low iodine diet for two weeks before the administration of sodium Iodide I-131.
3. Take on an empty stomach. Avoid eating for 2 hours before and after administering iodide I-131.

Interaksi Obat

11 Data

Carbimazole	The therapeutic efficacy of Iodide I-131 can be decreased when used in combination with Carbimazole.
Propylthiouracil	The therapeutic efficacy of Iodide I-131 can be decreased when used in combination with Propylthiouracil.
Methimazole	The therapeutic efficacy of Iodide I-131 can be decreased when used in combination with Methimazole.
3,5-Diiodotyrosine	The therapeutic efficacy of Iodide I-131 can be decreased when used in combination with 3,5-Diiodotyrosine.
Potassium Iodide	The therapeutic efficacy of Iodide I-131 can be decreased when used in combination with Potassium Iodide.
Dibromotyrosine	The therapeutic efficacy of Iodide I-131 can be decreased when used in combination with Dibromotyrosine.
Potassium perchlorate	The therapeutic efficacy of Iodide I-131 can be decreased when used in combination with Potassium perchlorate.
Methylthiouracil	The therapeutic efficacy of Iodide I-131 can be decreased when used in combination with Methylthiouracil.
Benzylthiouracil	The therapeutic efficacy of Iodide I-131 can be decreased when used in combination with Benzylthiouracil.
Amiodarone	Amiodarone may decrease effectiveness of Iodide I-131 as a diagnostic agent.
Ioversol	The therapeutic efficacy of Iodide I-131 can be decreased when used in combination with Ioversol.

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 14 • International brands: 0

Produk

Hicon

Solution • 1000 mCi/1mL • Oral • US • Approved
I 131 Mini

Capsule • 500 mCi/1 • Oral • US
I3odine MAXTM

Solution • 3500 mCi/1mL • Oral • US
Iodotope

Capsule, gelatin coated • 130 mCi/1 • Oral • US • Approved
Sodium Iodide I 131

Capsule, gelatin coated • 1 mCi/1mL • Oral • US • Approved
Sodium Iodide I 131

Capsule, gelatin coated • 1 mCi/1mL • Oral • US • Approved
Sodium Iodide I 131 Diagnostic

Capsule • 100 mCi/1 • Oral • US • Approved
Sodium Iodide I 131 Therapeutic

Capsule • 200 mCi/1 • Oral • US • Approved

Menampilkan 8 dari 14 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.