Most common adverse reactions occurring in >3% of patients receiving moderately emetogenic chemotherapy and combinations of anthracycline and cyclophosphamide included decreased appetite, neutropenia, dizziness, dyspepsia, urinary tract infection, stomatitis, and anemia. Most common adverse reactions occurring in patients receiving cisplatin-based highly emetogenic chemotherapy included neutropenia, hiccups, and abdominal pain.
Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its ligand Substance P, which is released in the gut following chemotherapy administration. Neurokinin-1 is also known as Tachykinin Receptor 1 (TACR1), Neurokinin 1 Receptor (NK1R), and Substance P Receptor (SPR).
By blocking Substance P from interacting with NK-1 receptors in the gut and the central nervous system, rolapitant prevents late-phase CINV. Unlike other available NK-1 receptor antagonists, rolapitant is not an inhibitor of Cytochrome P450 enzyme CYP3A4 and has a long elimination half-life, allowing a single dose to prevent both acute and late-phase CINV during the first 120 hours post-chemotherapy.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Afatinib | The serum concentration of Afatinib can be increased when it is combined with Rolapitant. |
| Bosutinib | The serum concentration of Bosutinib can be increased when it is combined with Rolapitant. |
| Brentuximab vedotin | The serum concentration of Brentuximab vedotin can be increased when it is combined with Rolapitant. |
| Colchicine | The serum concentration of Colchicine can be increased when it is combined with Rolapitant. |
| Edoxaban | The serum concentration of Edoxaban can be increased when it is combined with Rolapitant. |
| Ledipasvir | The serum concentration of Ledipasvir can be increased when it is combined with Rolapitant. |
| Naloxegol | The serum concentration of Naloxegol can be increased when it is combined with Rolapitant. |
| Pazopanib | The serum concentration of Pazopanib can be increased when it is combined with Rolapitant. |
| Prucalopride | The serum concentration of Prucalopride can be increased when it is combined with Rolapitant. |
| Ranolazine | The serum concentration of Ranolazine can be increased when it is combined with Rolapitant. |
| Silodosin | The excretion of Silodosin can be decreased when combined with Rolapitant. |
| Topotecan | The serum concentration of Topotecan can be increased when it is combined with Rolapitant. |
| Everolimus | The serum concentration of Everolimus can be increased when it is combined with Rolapitant. |
| Rifaximin | The serum concentration of Rifaximin can be increased when it is combined with Rolapitant. |
| Brexpiprazole | The metabolism of Brexpiprazole can be decreased when combined with Rolapitant. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Rolapitant. |
| Atomoxetine | The metabolism of Atomoxetine can be decreased when combined with Rolapitant. |
| Pimozide | The metabolism of Pimozide can be decreased when combined with Rolapitant. |
| Vincristine | The excretion of Vincristine can be decreased when combined with Rolapitant. |
| Doxorubicin | The serum concentration of Doxorubicin can be increased when it is combined with Rolapitant. |
| Bexarotene | The metabolism of Rolapitant can be increased when combined with Bexarotene. |
| Bosentan | The metabolism of Rolapitant can be increased when combined with Bosentan. |
| Nafcillin | The metabolism of Rolapitant can be increased when combined with Nafcillin. |
| Efavirenz | The metabolism of Rolapitant can be increased when combined with Efavirenz. |
| Modafinil | The metabolism of Rolapitant can be increased when combined with Modafinil. |
| Etravirine | The metabolism of Rolapitant can be increased when combined with Etravirine. |
| Avasimibe | The metabolism of Rolapitant can be increased when combined with Avasimibe. |
| Dexamethasone | The metabolism of Rolapitant can be increased when combined with Dexamethasone. |
| Echinacea | The metabolism of Rolapitant can be increased when combined with Echinacea. |
| Dexamethasone acetate | The metabolism of Rolapitant can be increased when combined with Dexamethasone acetate. |
| Imipramine | The metabolism of Imipramine can be decreased when combined with Rolapitant. |
| Clonidine | The metabolism of Clonidine can be decreased when combined with Rolapitant. |
| Trimipramine | The metabolism of Trimipramine can be decreased when combined with Rolapitant. |
| Gefitinib | The metabolism of Gefitinib can be decreased when combined with Rolapitant. |
| Tamoxifen | The metabolism of Tamoxifen can be decreased when combined with Rolapitant. |
| Ponatinib | The metabolism of Ponatinib can be decreased when combined with Rolapitant. |
| Revefenacin | The metabolism of Revefenacin can be decreased when combined with Rolapitant. |
| Dacomitinib | The metabolism of Dacomitinib can be decreased when combined with Rolapitant. |
| Rucaparib | The metabolism of Rucaparib can be decreased when combined with Rolapitant. |
| Enasidenib | The metabolism of Enasidenib can be decreased when combined with Rolapitant. |
| Citalopram | The metabolism of Citalopram can be decreased when combined with Rolapitant. |
| Metoprolol | The metabolism of Metoprolol can be decreased when combined with Rolapitant. |
| Acetaminophen | The metabolism of Acetaminophen can be decreased when combined with Rolapitant. |
| Olanzapine | The metabolism of Olanzapine can be decreased when combined with Rolapitant. |
| Progesterone | The metabolism of Progesterone can be decreased when combined with Rolapitant. |
| Quinine | The metabolism of Quinine can be decreased when combined with Rolapitant. |
| Chlorpromazine | The metabolism of Chlorpromazine can be decreased when combined with Rolapitant. |
| Erlotinib | The metabolism of Erlotinib can be decreased when combined with Rolapitant. |
| Propranolol | The metabolism of Propranolol can be decreased when combined with Rolapitant. |
| Chloroquine | The metabolism of Chloroquine can be decreased when combined with Rolapitant. |
| Ondansetron | The metabolism of Ondansetron can be decreased when combined with Rolapitant. |
| Nifedipine | The metabolism of Nifedipine can be decreased when combined with Rolapitant. |
| Domperidone | The metabolism of Domperidone can be decreased when combined with Rolapitant. |
| Acebutolol | The metabolism of Acebutolol can be decreased when combined with Rolapitant. |
| Nadolol | The metabolism of Nadolol can be decreased when combined with Rolapitant. |
| Paliperidone | The metabolism of Paliperidone can be decreased when combined with Rolapitant. |
| Debrisoquine | The metabolism of Debrisoquine can be decreased when combined with Rolapitant. |
| Celiprolol | The metabolism of Celiprolol can be decreased when combined with Rolapitant. |
| Fesoterodine | The metabolism of Fesoterodine can be decreased when combined with Rolapitant. |
| Mirabegron | The metabolism of Mirabegron can be decreased when combined with Rolapitant. |
| Umeclidinium | The metabolism of Umeclidinium can be decreased when combined with Rolapitant. |
| Dasabuvir | The metabolism of Dasabuvir can be decreased when combined with Rolapitant. |
| Asunaprevir | The metabolism of Asunaprevir can be decreased when combined with Rolapitant. |
| Talinolol | The metabolism of Talinolol can be decreased when combined with Rolapitant. |
| Elagolix | The metabolism of Elagolix can be decreased when combined with Rolapitant. |
| Nevirapine | The metabolism of Nevirapine can be decreased when combined with Rolapitant. |
| Fluvoxamine | The metabolism of Fluvoxamine can be decreased when combined with Rolapitant. |
| Diltiazem | The metabolism of Diltiazem can be decreased when combined with Rolapitant. |
| Risperidone | The metabolism of Risperidone can be decreased when combined with Rolapitant. |
| Sertraline | The metabolism of Sertraline can be decreased when combined with Rolapitant. |
| Fusidic acid | The metabolism of Fusidic acid can be decreased when combined with Rolapitant. |
| Netupitant | The metabolism of Netupitant can be decreased when combined with Rolapitant. |
| Amphetamine | The metabolism of Amphetamine can be decreased when combined with Rolapitant. |
| Cevimeline | The metabolism of Cevimeline can be decreased when combined with Rolapitant. |
| Esmolol | The metabolism of Esmolol can be decreased when combined with Rolapitant. |
| Bortezomib | The metabolism of Bortezomib can be decreased when combined with Rolapitant. |
| Betaxolol | The metabolism of Betaxolol can be decreased when combined with Rolapitant. |
| Ticlopidine | The metabolism of Ticlopidine can be decreased when combined with Rolapitant. |
| Benzatropine | The metabolism of Benzatropine can be decreased when combined with Rolapitant. |
| Lidocaine | The metabolism of Lidocaine can be decreased when combined with Rolapitant. |
| Venlafaxine | The metabolism of Venlafaxine can be decreased when combined with Rolapitant. |
| Bupivacaine | The metabolism of Bupivacaine can be decreased when combined with Rolapitant. |
| Codeine | The metabolism of Codeine can be decreased when combined with Rolapitant. |
| Atenolol | The metabolism of Atenolol can be decreased when combined with Rolapitant. |
| Chlorzoxazone | The metabolism of Chlorzoxazone can be decreased when combined with Rolapitant. |
| Mirtazapine | The metabolism of Mirtazapine can be decreased when combined with Rolapitant. |
| Palonosetron | The metabolism of Palonosetron can be decreased when combined with Rolapitant. |
| Mexiletine | The metabolism of Mexiletine can be decreased when combined with Rolapitant. |
| Remoxipride | The metabolism of Remoxipride can be decreased when combined with Rolapitant. |
| Promazine | The metabolism of Promazine can be decreased when combined with Rolapitant. |
| Prochlorperazine | The metabolism of Prochlorperazine can be decreased when combined with Rolapitant. |
| Fluoxetine | The metabolism of Fluoxetine can be decreased when combined with Rolapitant. |
| Duloxetine | The metabolism of Duloxetine can be decreased when combined with Rolapitant. |
| Celecoxib | The metabolism of Celecoxib can be decreased when combined with Rolapitant. |
| Sotalol | The metabolism of Sotalol can be decreased when combined with Rolapitant. |
| Oxycodone | The metabolism of Oxycodone can be decreased when combined with Rolapitant. |
| Dextromethorphan | The metabolism of Dextromethorphan can be decreased when combined with Rolapitant. |
| Mephenytoin | The metabolism of Mephenytoin can be decreased when combined with Rolapitant. |
| Amoxapine | The metabolism of Amoxapine can be decreased when combined with Rolapitant. |
| Cinnarizine | The metabolism of Cinnarizine can be decreased when combined with Rolapitant. |