Ramosetron

DB09290

small molecule investigational

Deskripsi

Ramosetron is a serotonin 5-HT3 receptor antagonist commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. Currently, ramosetron is only approved for use Japan and in certain Southeast Asian countries.

Struktur Molekul 2D

Berat 279.343
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

992 Data
Deferasirox The serum concentration of Ramosetron can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Ramosetron can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Ramosetron can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Ramosetron can be decreased when it is combined with Teriflunomide.
Buprenorphine Ramosetron may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ramosetron.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Ramosetron.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Ramosetron.
Hydrocodone Ramosetron may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ramosetron.
Magnesium sulfate The therapeutic efficacy of Ramosetron can be increased when used in combination with Magnesium sulfate.
Metyrosine Ramosetron may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Ramosetron.
Mirtazapine Ramosetron may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Ramosetron.
Paraldehyde Ramosetron may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Ramosetron.
Pramipexole Ramosetron may increase the sedative activities of Pramipexole.
Ropinirole Ramosetron may increase the sedative activities of Ropinirole.
Rotigotine Ramosetron may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Ramosetron.
Sodium oxybate Ramosetron may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Ramosetron may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ramosetron.
Thalidomide Ramosetron may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Ramosetron may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Ramosetron.
Dicoumarol The risk or severity of adverse effects can be increased when Ramosetron is combined with Dicoumarol.
Phenindione The risk or severity of adverse effects can be increased when Ramosetron is combined with Phenindione.
Phenprocoumon The risk or severity of adverse effects can be increased when Ramosetron is combined with Phenprocoumon.
4-hydroxycoumarin The risk or severity of adverse effects can be increased when Ramosetron is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of adverse effects can be increased when Ramosetron is combined with Coumarin.
Ethyl biscoumacetate The risk or severity of adverse effects can be increased when Ramosetron is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of adverse effects can be increased when Ramosetron is combined with Fluindione.
Clorindione The risk or severity of adverse effects can be increased when Ramosetron is combined with Clorindione.
Diphenadione The risk or severity of adverse effects can be increased when Ramosetron is combined with Diphenadione.
Tioclomarol The risk or severity of adverse effects can be increased when Ramosetron is combined with Tioclomarol.
(S)-Warfarin The risk or severity of adverse effects can be increased when Ramosetron is combined with (S)-Warfarin.
Abiraterone The serum concentration of Ramosetron can be increased when it is combined with Abiraterone.
Trospium The risk or severity of constipation can be increased when Trospium is combined with Ramosetron.
Oxyphenonium The risk or severity of constipation can be increased when Oxyphenonium is combined with Ramosetron.
Benzatropine The risk or severity of constipation can be increased when Benzatropine is combined with Ramosetron.
Disopyramide The risk or severity of constipation can be increased when Disopyramide is combined with Ramosetron.
Amitriptyline The risk or severity of constipation can be increased when Amitriptyline is combined with Ramosetron.
Ipratropium The risk or severity of constipation can be increased when Ipratropium is combined with Ramosetron.
Olanzapine The risk or severity of constipation can be increased when Olanzapine is combined with Ramosetron.
Metixene The risk or severity of constipation can be increased when Metixene is combined with Ramosetron.
Terfenadine The risk or severity of constipation can be increased when Terfenadine is combined with Ramosetron.
Buclizine The risk or severity of constipation can be increased when Buclizine is combined with Ramosetron.
Clozapine The risk or severity of constipation can be increased when Clozapine is combined with Ramosetron.
Trihexyphenidyl The risk or severity of constipation can be increased when Trihexyphenidyl is combined with Ramosetron.
Oxyphencyclimine The risk or severity of constipation can be increased when Oxyphencyclimine is combined with Ramosetron.
Procyclidine The risk or severity of constipation can be increased when Procyclidine is combined with Ramosetron.
Profenamine The risk or severity of constipation can be increased when Profenamine is combined with Ramosetron.
Promazine The risk or severity of constipation can be increased when Promazine is combined with Ramosetron.
Hyoscyamine The risk or severity of constipation can be increased when Hyoscyamine is combined with Ramosetron.
Cyproheptadine The risk or severity of constipation can be increased when Cyproheptadine is combined with Ramosetron.
Imipramine The risk or severity of constipation can be increased when Imipramine is combined with Ramosetron.
Methscopolamine bromide The risk or severity of constipation can be increased when Methscopolamine bromide is combined with Ramosetron.
Chlorpromazine The risk or severity of constipation can be increased when Chlorpromazine is combined with Ramosetron.
Gallamine triethiodide The risk or severity of constipation can be increased when Gallamine triethiodide is combined with Ramosetron.
Darifenacin The risk or severity of constipation can be increased when Darifenacin is combined with Ramosetron.
Tridihexethyl The risk or severity of constipation can be increased when Tridihexethyl is combined with Ramosetron.
Triflupromazine The risk or severity of constipation can be increased when Triflupromazine is combined with Ramosetron.
Anisotropine methylbromide The risk or severity of constipation can be increased when Anisotropine methylbromide is combined with Ramosetron.
Nortriptyline The risk or severity of constipation can be increased when Nortriptyline is combined with Ramosetron.
Amoxapine The risk or severity of constipation can be increased when Amoxapine is combined with Ramosetron.
Lamotrigine The risk or severity of CNS depression can be increased when Lamotrigine is combined with Ramosetron.
Atropine The risk or severity of constipation can be increased when Atropine is combined with Ramosetron.
Nicardipine The risk or severity of constipation can be increased when Nicardipine is combined with Ramosetron.
Pirenzepine The risk or severity of constipation can be increased when Pirenzepine is combined with Ramosetron.
Paroxetine The risk or severity of constipation can be increased when Paroxetine is combined with Ramosetron.
Homatropine methylbromide The risk or severity of constipation can be increased when Homatropine methylbromide is combined with Ramosetron.
Rocuronium The risk or severity of constipation can be increased when Rocuronium is combined with Ramosetron.
Scopolamine The risk or severity of constipation can be increased when Scopolamine is combined with Ramosetron.
Benzquinamide The risk or severity of constipation can be increased when Benzquinamide is combined with Ramosetron.
Clidinium The risk or severity of constipation can be increased when Clidinium is combined with Ramosetron.
Propiomazine The risk or severity of constipation can be increased when Propiomazine is combined with Ramosetron.
Propantheline The risk or severity of constipation can be increased when Propantheline is combined with Ramosetron.
Dicyclomine The risk or severity of constipation can be increased when Dicyclomine is combined with Ramosetron.
Biperiden The risk or severity of constipation can be increased when Biperiden is combined with Ramosetron.
Brompheniramine The risk or severity of constipation can be increased when Brompheniramine is combined with Ramosetron.
Flupentixol The risk or severity of constipation can be increased when Flupentixol is combined with Ramosetron.
Cocaine The risk or severity of constipation can be increased when Cocaine is combined with Ramosetron.
Quinidine The risk or severity of constipation can be increased when Quinidine is combined with Ramosetron.
Maprotiline The risk or severity of constipation can be increased when Maprotiline is combined with Ramosetron.
Methantheline The risk or severity of constipation can be increased when Methantheline is combined with Ramosetron.
Cycrimine The risk or severity of constipation can be increased when Cycrimine is combined with Ramosetron.
Glycopyrronium The risk or severity of constipation can be increased when Glycopyrronium is combined with Ramosetron.
Tolterodine The risk or severity of constipation can be increased when Tolterodine is combined with Ramosetron.
Oxybutynin The risk or severity of constipation can be increased when Oxybutynin is combined with Ramosetron.
Promethazine The risk or severity of constipation can be increased when Promethazine is combined with Ramosetron.
Diphenhydramine The risk or severity of constipation can be increased when Diphenhydramine is combined with Ramosetron.
Doxacurium The risk or severity of constipation can be increased when Doxacurium is combined with Ramosetron.
Doxepin The risk or severity of constipation can be increased when Doxepin is combined with Ramosetron.
Flavoxate The risk or severity of constipation can be increased when Flavoxate is combined with Ramosetron.
Desipramine The risk or severity of constipation can be increased when Desipramine is combined with Ramosetron.
Orphenadrine Ramosetron may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Escitalopram The risk or severity of constipation can be increased when Escitalopram is combined with Ramosetron.
Quetiapine The risk or severity of constipation can be increased when Quetiapine is combined with Ramosetron.

Target Protein

5-hydroxytryptamine receptor 3A HTR3A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 10648342
    Fujii Y, Saitoh Y, Tanaka H, Toyooka H: Ramosetron for preventing postoperative nausea and vomiting in women undergoing gynecological surgery. Anesth Analg. 2000 Feb;90(2):472-5.
  • PMID: 26558626
    Lee SH, Cho SY, Yoo KY, Jeong S: Population pharmacokinetics of ramosetron. J Pharmacokinet Pharmacodyn. 2016 Feb;43(1):73-83. doi: 10.1007/s10928-015-9455-8. Epub 2015 Nov 11.

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