Peringatan Keamanan

As with other anti-inflammatory medications, adverse effects may include: agranulocytosis, bleeding, hepatotoxicity, acute renal failure, dermatoses, and rarely angioedema and urticaria L1496.

Morniflumate

DB09285

small molecule experimental

Deskripsi

Morniflumate is a non-steroidal anti-inflammatory drug with antipyretic properties. It is the morpholinoethyl ester of niflumic acid L1496. In one study, post morniflumate ingestion, physical examination and clinical symptoms of those with bronchitis showed improvement A7889.

Struktur Molekul 2D

Berat 395.382
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2h [L1498]
Volume Distribusi -
Klirens (Clearance) 45 ml/min [L1498]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

The pharmacokinetic availability of niflumic acid in two different pharmaceutical preparations have been studied in 12 subjects after oral administration L1498. Bioavailability and pharmacokinetics studies after oral and intravenous (IV) administration demonstrate that morniflumate is absorbed as from the gastrointestinal tract, followed by rapid hydrolysis in the plasma, releasing the free acidic form, the molecule responsible for its anti-inflammatory effects. The ester displays gastroprotective effect against the ulcerogenic effects of niflumic acid L1496.

Rute Eliminasi

0.12 L /kg on average L1498

Interaksi Obat

1386 Data
Amlodipine Morniflumate may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Morniflumate.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Morniflumate.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Morniflumate.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Morniflumate.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Morniflumate.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Morniflumate.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Morniflumate.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Morniflumate.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Morniflumate.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Morniflumate.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Morniflumate.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Morniflumate.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Morniflumate.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Morniflumate.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Morniflumate.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Morniflumate.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Morniflumate.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Morniflumate.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Morniflumate.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Morniflumate.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Morniflumate.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Morniflumate.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Morniflumate.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Morniflumate.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Morniflumate.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Morniflumate.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Morniflumate.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Morniflumate.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Morniflumate.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Morniflumate.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Morniflumate.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Morniflumate.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Morniflumate.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Morniflumate.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Morniflumate.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Morniflumate.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Morniflumate.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Morniflumate.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Morniflumate.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Morniflumate.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Morniflumate.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Morniflumate.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Morniflumate.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Morniflumate.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Morniflumate.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Morniflumate.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Morniflumate.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Morniflumate.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Morniflumate.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Morniflumate.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Morniflumate.
Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Morniflumate.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Morniflumate.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Morniflumate.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Morniflumate.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Morniflumate.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Morniflumate.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Morniflumate.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Morniflumate.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Morniflumate.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Morniflumate.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Morniflumate.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Morniflumate.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Morniflumate.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Morniflumate.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Morniflumate.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Morniflumate.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Morniflumate.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Morniflumate.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Morniflumate.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Morniflumate.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Morniflumate.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Morniflumate.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Morniflumate.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Morniflumate.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Morniflumate.
MMDA The risk or severity of hypertension can be increased when MMDA is combined with Morniflumate.
Midomafetamine The risk or severity of hypertension can be increased when Midomafetamine is combined with Morniflumate.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Morniflumate.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Morniflumate.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Morniflumate.
Tenamfetamine The risk or severity of hypertension can be increased when Tenamfetamine is combined with Morniflumate.
Chlorphentermine The risk or severity of hypertension can be increased when Chlorphentermine is combined with Morniflumate.
Dextroamphetamine The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Morniflumate.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Morniflumate.
Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Morniflumate.
Periciazine The risk or severity of hypertension can be increased when Periciazine is combined with Morniflumate.
Acepromazine The risk or severity of hypertension can be increased when Acepromazine is combined with Morniflumate.
Thioproperazine The risk or severity of hypertension can be increased when Thioproperazine is combined with Morniflumate.
Zuclopenthixol The risk or severity of hypertension can be increased when Zuclopenthixol is combined with Morniflumate.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Morniflumate.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Morniflumate.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Morniflumate.
Iproniazid The risk or severity of hypertension can be increased when Iproniazid is combined with Morniflumate.
Nialamide The risk or severity of hypertension can be increased when Nialamide is combined with Morniflumate.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Lysergic acid diethylamide is combined with Morniflumate.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Morniflumate.
Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Morniflumate.
Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Morniflumate.

Target Protein

Prostaglandin G/H synthase 1 PTGS1
Prostaglandin G/H synthase 2 PTGS2
Polyunsaturated fatty acid 5-lipoxygenase ALOX5
Leukotriene B4 receptor 1 LTB4R
Thromboxane A2 receptor TBXA2R

Referensi & Sumber

Artikel (PubMed)
  • PMID: 1796197
    Melica A, Donateo L, Gerardi R, Parenti M: A new anti-inflammatory-analgesic-antipyretic, morniflumate, in the treatment of chronic recurring bronchitis. Riv Eur Sci Med Farmacol. 1991 Feb-Apr;13(1-2):51-60.
  • PMID: 1659152
    Civelli M, Vigano T, Acerbi D, Caruso P, Giossi M, Bongrani S, Folco GC: Modulation of arachidonic acid metabolism by orally administered morniflumate in man. Agents Actions. 1991 Jul;33(3-4):233-9.
  • PMID: 6608862
    Schiantarelli P, Cadel S, Acerbi D: A gastroprotective anti-inflammatory agent: the beta-morpholinoethyl ester of niflumic acid (morniflumate). Agents Actions. 1984 Feb;14(2):247-56.
  • PMID: 16278927
    Mano Y, Usui T, Kamimura H: In vitro inhibitory effects of non-steroidal anti-inflammatory drugs on 4-methylumbelliferone glucuronidation in recombinant human UDP-glucuronosyltransferase 1A9--potent inhibition by niflumic acid. Biopharm Drug Dispos. 2006 Jan;27(1):1-6. doi: 10.1002/bdd.475.
  • PMID: 12920213
    Sinkkonen ST, Mansikkamaki S, Moykkynen T, Luddens H, Uusi-Oukari M, Korpi ER: Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug. Mol Pharmacol. 2003 Sep;64(3):753-63. doi: 10.1124/mol.64.3.753.

Contoh Produk & Brand

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