Molsidomine

DB09282

small molecule approved investigational

Deskripsi

Molsidomine is an orally active, long-acting vasodilator, which belongs to the class of medications known as syndnones. Interestingly, it is being studied as being a preventive measure in cerebral infarction A31932.

Struktur Molekul 2D

Berat 242.235
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi 98 L [L1369]
Klirens (Clearance) renal excretion is the main route of elimination of the metabolites in humans (90% to 95%) About 2% of the ingested drug is excreted unchanged in the urine.

Absorpsi

Peak plasma drug concentration (tmax) occurs from 1 to 2 hours after administration.

Metabolisme

Molsidomine hepatically metabolized to linsidomine. Linsidomine releases nitric oxide (NO) from endothelial cells when it decays, and acts as the active vasodilating metabolite responsible for molsidomine's pharmacological effects. Oral absorption of Molsidomine is found to be 95.5% ±4.5. Presystemic metabolism is noted to be 56% and metabolism is reported extensive by Liver. Renal Excretion accounts for 95 % and plasma half-life is 5 hr. Back to top

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

192 Data
Nitroglycerin Molsidomine may increase the hypotensive activities of Nitroglycerin.
Isosorbide dinitrate Molsidomine may increase the hypotensive activities of Isosorbide dinitrate.
Amyl Nitrite Molsidomine may increase the hypotensive activities of Amyl Nitrite.
Erythrityl tetranitrate Molsidomine may increase the hypotensive activities of Erythrityl tetranitrate.
Pentaerythritol tetranitrate Molsidomine may increase the hypotensive activities of Pentaerythritol tetranitrate.
Isosorbide Molsidomine may increase the hypotensive activities of Isosorbide.
Propatyl nitrate Molsidomine may increase the hypotensive activities of Propatyl nitrate.
Methylpropylpropanediol dinitrate Molsidomine may increase the hypotensive activities of Methylpropylpropanediol dinitrate.
Tenitramine Molsidomine may increase the hypotensive activities of Tenitramine.
Trolnitrate Molsidomine may increase the hypotensive activities of Trolnitrate.
Nitrate Molsidomine may increase the hypotensive activities of Nitrate.
Valsartan Molsidomine may increase the hypotensive activities of Valsartan.
Ramipril Molsidomine may increase the hypotensive activities of Ramipril.
Esmolol Molsidomine may increase the hypotensive activities of Esmolol.
Betaxolol Molsidomine may increase the hypotensive activities of Betaxolol.
Reserpine Molsidomine may increase the hypotensive activities of Reserpine.
Remikiren Molsidomine may increase the hypotensive activities of Remikiren.
Torasemide Molsidomine may increase the hypotensive activities of Torasemide.
Bethanidine Molsidomine may increase the hypotensive activities of Bethanidine.
Guanadrel Molsidomine may increase the hypotensive activities of Guanadrel.
Metoprolol Molsidomine may increase the hypotensive activities of Metoprolol.
Isradipine Molsidomine may increase the hypotensive activities of Isradipine.
Olmesartan Molsidomine may increase the hypotensive activities of Olmesartan.
Chlorthalidone Molsidomine may increase the hypotensive activities of Chlorthalidone.
Nitroprusside Molsidomine may increase the hypotensive activities of Nitroprusside.
Atenolol Molsidomine may increase the hypotensive activities of Atenolol.
Diltiazem Molsidomine may increase the hypotensive activities of Diltiazem.
Minoxidil Molsidomine may increase the hypotensive activities of Minoxidil.
Timolol Molsidomine may increase the hypotensive activities of Timolol.
Treprostinil Molsidomine may increase the hypotensive activities of Treprostinil.
Amlodipine Molsidomine may increase the hypotensive activities of Amlodipine.
Nimodipine Molsidomine may increase the hypotensive activities of Nimodipine.
Nisoldipine Molsidomine may increase the hypotensive activities of Nisoldipine.
Bendroflumethiazide Molsidomine may increase the hypotensive activities of Bendroflumethiazide.
Prazosin Molsidomine may increase the hypotensive activities of Prazosin.
Fosinopril Molsidomine may increase the hypotensive activities of Fosinopril.
Trandolapril Molsidomine may increase the hypotensive activities of Trandolapril.
Metolazone Molsidomine may increase the hypotensive activities of Metolazone.
Lercanidipine Molsidomine may increase the hypotensive activities of Lercanidipine.
Benazepril Molsidomine may increase the hypotensive activities of Benazepril.
Bosentan Molsidomine may increase the hypotensive activities of Bosentan.
Propranolol Molsidomine may increase the hypotensive activities of Propranolol.
Clonidine Molsidomine may increase the hypotensive activities of Clonidine.
Enalapril Molsidomine may increase the hypotensive activities of Enalapril.
Doxazosin Molsidomine may increase the hypotensive activities of Doxazosin.
Labetalol Molsidomine may increase the hypotensive activities of Labetalol.
Cyclothiazide Molsidomine may increase the hypotensive activities of Cyclothiazide.
Bisoprolol Molsidomine may increase the hypotensive activities of Bisoprolol.
Candoxatril Molsidomine may increase the hypotensive activities of Candoxatril.
Nicardipine Molsidomine may increase the hypotensive activities of Nicardipine.
Guanabenz Molsidomine may increase the hypotensive activities of Guanabenz.
Mecamylamine Molsidomine may increase the hypotensive activities of Mecamylamine.
Losartan Molsidomine may increase the hypotensive activities of Losartan.
Moexipril Molsidomine may increase the hypotensive activities of Moexipril.
Phentolamine Molsidomine may increase the hypotensive activities of Phentolamine.
Eplerenone Molsidomine may increase the hypotensive activities of Eplerenone.
Lisinopril Molsidomine may increase the hypotensive activities of Lisinopril.
Metyrosine Molsidomine may increase the hypotensive activities of Metyrosine.
Hydroflumethiazide Molsidomine may increase the hypotensive activities of Hydroflumethiazide.
Cryptenamine Molsidomine may increase the hypotensive activities of Cryptenamine.
Perindopril Molsidomine may increase the hypotensive activities of Perindopril.
Candesartan cilexetil Molsidomine may increase the hypotensive activities of Candesartan cilexetil.
Tolazoline Molsidomine may increase the hypotensive activities of Tolazoline.
Fenoldopam Molsidomine may increase the hypotensive activities of Fenoldopam.
Indapamide Molsidomine may increase the hypotensive activities of Indapamide.
Alprenolol Molsidomine may increase the hypotensive activities of Alprenolol.
Eprosartan Molsidomine may increase the hypotensive activities of Eprosartan.
Chlorothiazide Molsidomine may increase the hypotensive activities of Chlorothiazide.
Quinapril Molsidomine may increase the hypotensive activities of Quinapril.
Omapatrilat Molsidomine may increase the hypotensive activities of Omapatrilat.
Phenoxybenzamine Molsidomine may increase the hypotensive activities of Phenoxybenzamine.
Pindolol Molsidomine may increase the hypotensive activities of Pindolol.
Telmisartan Molsidomine may increase the hypotensive activities of Telmisartan.
Methyldopa Molsidomine may increase the hypotensive activities of Methyldopa.
Hydrochlorothiazide Molsidomine may increase the hypotensive activities of Hydrochlorothiazide.
Guanfacine Molsidomine may increase the hypotensive activities of Guanfacine.
Trichlormethiazide Molsidomine may increase the hypotensive activities of Trichlormethiazide.
Felodipine Molsidomine may increase the hypotensive activities of Felodipine.
Irbesartan Molsidomine may increase the hypotensive activities of Irbesartan.
Nitrendipine Molsidomine may increase the hypotensive activities of Nitrendipine.
Deserpidine Molsidomine may increase the hypotensive activities of Deserpidine.
Pentolinium Molsidomine may increase the hypotensive activities of Pentolinium.
Trimethaphan Molsidomine may increase the hypotensive activities of Trimethaphan.
Diazoxide Molsidomine may increase the hypotensive activities of Diazoxide.
Carvedilol Molsidomine may increase the hypotensive activities of Carvedilol.
Bretylium Molsidomine may increase the hypotensive activities of Bretylium.
Terazosin Molsidomine may increase the hypotensive activities of Terazosin.
Guanethidine Molsidomine may increase the hypotensive activities of Guanethidine.
Rescinnamine Molsidomine may increase the hypotensive activities of Rescinnamine.
Acebutolol Molsidomine may increase the hypotensive activities of Acebutolol.
Captopril Molsidomine may increase the hypotensive activities of Captopril.
Nadolol Molsidomine may increase the hypotensive activities of Nadolol.
Epoprostenol Molsidomine may increase the hypotensive activities of Epoprostenol.
Bepridil Molsidomine may increase the hypotensive activities of Bepridil.
Hydralazine Molsidomine may increase the hypotensive activities of Hydralazine.
Bevantolol Molsidomine may increase the hypotensive activities of Bevantolol.
Practolol Molsidomine may increase the hypotensive activities of Practolol.
Polythiazide Molsidomine may increase the hypotensive activities of Polythiazide.
Cilazapril Molsidomine may increase the hypotensive activities of Cilazapril.
Saprisartan Molsidomine may increase the hypotensive activities of Saprisartan.

Target Protein

Guanylate cyclase soluble subunit alpha-2 GUCY1A2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 26162034
    Ehlert A, Schmidt C, Wolfer J, Manthei G, Jacobs AH, Bruning R, Heindel W, Ringelstein EB, Stummer W, Pluta RM, Hesselmann V: Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study. J Neurosurg. 2016 Jan;124(1):51-8. doi: 10.3171/2014.12.JNS13846. Epub 2015 Jul 10.
  • PMID: 24090640
    Lorenc-Koci E, Czarnecka A, Lenda T, Kaminska K, Konieczny J: Molsidomine, a nitric oxide donor, modulates rotational behavior and monoamine metabolism in 6-OHDA lesioned rats treated chronically with L-DOPA. Neurochem Int. 2013 Dec;63(8):790-804. doi: 10.1016/j.neuint.2013.09.021. Epub 2013 Sep 30.
  • PMID: 8743336
    Rosenkranz B, Winkelmann BR, Parnham MJ: Clinical pharmacokinetics of molsidomine. Clin Pharmacokinet. 1996 May;30(5):372-84.
  • PMID: 3838399
    Ostrowski J, Resag K: Pharmacokinetics of molsidomine in humans. Am Heart J. 1985 Mar;109(3 Pt 2):641-3.

Contoh Produk & Brand

Produk: 0 • International brands: 7
International Brands
  • Angoral — Pharmaghreb
  • Cardamine — ADWYA
  • Corvasal — Benta
  • Dilacor — Saiph
  • Molsicor — IBN
  • Molsidomina Polfa — Polfa
  • Molsidomine Arrow — Arrow

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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