Peringatan Keamanan

Adequate doses of magnesium trisilicate may cause diarrhea due to the action of soluble magnesium salts in the enteric tract. Approx 5% of the magnesium is absorbed.

Magnesium trisilicate

DB09281

small molecule approved

Deskripsi

Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.

Struktur Molekul 2D

Berat 260.857
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 16-20 hours
Volume Distribusi The hydrated silicon dioxide formed in the stomach and passes into the intestinal track.
Klirens (Clearance) Maximum magnesium clearance is directly proportional to creatinine clearance.

Absorpsi

The hydrated silicon dioxide formed in the stomach and passes into the intestinal track where, silica can be partly absorbed.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Excreted in the urine.

Interaksi Obat

1292 Data
Succinylcholine The therapeutic efficacy of Succinylcholine can be increased when used in combination with Magnesium trisilicate.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Magnesium trisilicate.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Magnesium trisilicate.
Cisatracurium The therapeutic efficacy of Cisatracurium can be increased when used in combination with Magnesium trisilicate.
Rocuronium The therapeutic efficacy of Rocuronium can be increased when used in combination with Magnesium trisilicate.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Magnesium trisilicate.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium trisilicate.
Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Magnesium trisilicate.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium trisilicate.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Magnesium trisilicate.
Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Magnesium trisilicate.
Pipecuronium The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium trisilicate.
Vecuronium The therapeutic efficacy of Vecuronium can be increased when used in combination with Magnesium trisilicate.
Rapacuronium The therapeutic efficacy of Rapacuronium can be increased when used in combination with Magnesium trisilicate.
Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Magnesium trisilicate.
Neosaxitoxin The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Magnesium trisilicate.
Atracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Magnesium trisilicate.
Gallamine The therapeutic efficacy of Gallamine can be increased when used in combination with Magnesium trisilicate.
Alcuronium The therapeutic efficacy of Alcuronium can be increased when used in combination with Magnesium trisilicate.
Tubocurarine The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium trisilicate.
Atazanavir Magnesium trisilicate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bosutinib Magnesium trisilicate can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cefditoren The serum concentration of Cefditoren can be decreased when it is combined with Magnesium trisilicate.
Dabigatran etexilate Magnesium trisilicate can cause a decrease in the absorption of Dabigatran etexilate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dabrafenib Magnesium trisilicate can cause a decrease in the absorption of Dabrafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dasatinib Magnesium trisilicate can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delavirdine Magnesium trisilicate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Erlotinib Magnesium trisilicate can cause a decrease in the absorption of Erlotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gefitinib Magnesium trisilicate can cause a decrease in the absorption of Gefitinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Itraconazole Magnesium trisilicate can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ledipasvir Magnesium trisilicate can cause a decrease in the absorption of Ledipasvir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylphenidate Magnesium trisilicate can cause an increase in the absorption of Methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
Pazopanib Magnesium trisilicate can cause a decrease in the absorption of Pazopanib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Riociguat Magnesium trisilicate can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcitriol The serum concentration of Magnesium trisilicate can be increased when it is combined with Calcitriol.
Calcifediol The serum concentration of Magnesium trisilicate can be increased when it is combined with Calcifediol.
Ergocalciferol The serum concentration of Magnesium trisilicate can be increased when it is combined with Ergocalciferol.
Cholecalciferol The serum concentration of Magnesium trisilicate can be increased when it is combined with Cholecalciferol.
Paricalcitol The serum concentration of Magnesium trisilicate can be increased when it is combined with Paricalcitol.
Dihydrotachysterol The serum concentration of Magnesium trisilicate can be increased when it is combined with Dihydrotachysterol.
Alfacalcidol The serum concentration of Magnesium trisilicate can be increased when it is combined with Alfacalcidol.
Seocalcitol The serum concentration of Magnesium trisilicate can be increased when it is combined with Seocalcitol.
Inecalcitol The serum concentration of Magnesium trisilicate can be increased when it is combined with Inecalcitol.
Becocalcidiol The serum concentration of Magnesium trisilicate can be increased when it is combined with Becocalcidiol.
Eldecalcitol The serum concentration of Magnesium trisilicate can be increased when it is combined with Eldecalcitol.
1alpha,24S-Dihydroxyvitamin D2 The serum concentration of Magnesium trisilicate can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
Elocalcitol The serum concentration of Magnesium trisilicate can be increased when it is combined with Elocalcitol.
Maxacalcitol The serum concentration of Magnesium trisilicate can be increased when it is combined with Maxacalcitol.
Doxercalciferol The serum concentration of Magnesium trisilicate can be increased when it is combined with Doxercalciferol.
Vitamin D The serum concentration of Magnesium trisilicate can be increased when it is combined with Vitamin D.
1alpha-Hydroxyvitamin D5 The serum concentration of Magnesium trisilicate can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
Previtamin D(3) The serum concentration of Magnesium trisilicate can be increased when it is combined with Previtamin D(3).
Deferiprone Magnesium trisilicate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eltrombopag Magnesium trisilicate can cause a decrease in the absorption of Eltrombopag resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levothyroxine Magnesium trisilicate can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tolevamer The risk or severity of adverse effects can be increased when Tolevamer is combined with Magnesium trisilicate.
Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Magnesium trisilicate.
Captopril Magnesium trisilicate can cause a decrease in the absorption of Captopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cefpodoxime The serum concentration of Cefpodoxime can be decreased when it is combined with Magnesium trisilicate.
Cefuroxime The serum concentration of Cefuroxime can be decreased when it is combined with Magnesium trisilicate.
Chloroquine Magnesium trisilicate can cause a decrease in the absorption of Chloroquine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Elvitegravir Magnesium trisilicate can cause a decrease in the absorption of Elvitegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gabapentin enacarbil The serum concentration of Gabapentin enacarbil can be decreased when it is combined with Magnesium trisilicate.
Hyoscyamine Magnesium trisilicate can cause a decrease in the absorption of Hyoscyamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rifampin Magnesium trisilicate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mecamylamine Magnesium trisilicate may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
Memantine Magnesium trisilicate may decrease the excretion rate of Memantine which could result in a higher serum level.
Penicillamine Magnesium trisilicate can cause a decrease in the absorption of Penicillamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Quinidine Magnesium trisilicate may decrease the excretion rate of Quinidine which could result in a higher serum level.
Quinine Magnesium trisilicate can cause a decrease in the absorption of Quinine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sotalol The serum concentration of Sotalol can be decreased when it is combined with Magnesium trisilicate.
Sulpiride The therapeutic efficacy of Sulpiride can be increased when used in combination with Magnesium trisilicate.
Deferasirox Magnesium trisilicate can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol The therapeutic efficacy of Allopurinol can be decreased when used in combination with Magnesium trisilicate.
Fexofenadine Magnesium trisilicate can cause a decrease in the absorption of Fexofenadine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raltegravir Magnesium trisilicate can cause a decrease in the absorption of Raltegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Halofantrine Magnesium trisilicate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Misoprostol The risk or severity of adverse effects can be increased when Magnesium trisilicate is combined with Misoprostol.
Mesalazine Magnesium trisilicate can cause a decrease in the absorption of Mesalazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cysteamine The bioavailability of Cysteamine can be decreased when combined with Magnesium trisilicate.
Ketoconazole Magnesium trisilicate can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trospium The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Trospium.
Oxyphenonium The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Oxyphenonium.
Ziprasidone The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Ziprasidone.
Ipratropium The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Ipratropium.
Olanzapine The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Olanzapine.
Metixene The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Metixene.
Terfenadine The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Terfenadine.
Buclizine The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Buclizine.
Doxylamine The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Doxylamine.
Trihexyphenidyl The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Trihexyphenidyl.
Oxyphencyclimine The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Oxyphencyclimine.
Procyclidine The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Procyclidine.
Profenamine The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Profenamine.
Cyproheptadine The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Cyproheptadine.
Methscopolamine bromide The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Methscopolamine bromide.
Darifenacin The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Darifenacin.
Tridihexethyl The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Tridihexethyl.
Anisotropine methylbromide The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Anisotropine methylbromide.
Nortriptyline The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Nortriptyline.

Referensi & Sumber

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