Peringatan Keamanan

Overdosage symptoms are those of heavy metal toxicity; they include pruritus, dermatitis, stomatitis, vague gastrointestinal discomfort, albuminuria with or without a nephrotic syndrome, hematuria, agranulocytosis, thrombocytopenic purpura, and aplastic anemia.

Sodium aurothiomalate

DB09276

small molecule approved investigational

Deskripsi

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.

Struktur Molekul 2D

Berat 390.07
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 12.5 days
Volume Distribusi The apparent volume of distribution is 0.26 +/- 0.051 kg-1
Klirens (Clearance) 7.0 ml/ kg/day

Absorpsi

Gold sodium thiomalate solutions are rapidly absorbed following IM injection, with peak serum concentrations occurring in 3-6 hours.

Metabolisme

No data available.

Rute Eliminasi

The major route of elimination of an IV dose of gold sodium thiomalate is urinary excretion, with a mean of 35% of the dose found in the urine in ten days. Fecal elimination accounts for an additional 9.4% of the IV dose excreted in ten days, probably as a result of biliary secretion.

Interaksi Obat

808 Data
Irinotecan The risk or severity of neutropenia can be increased when Sodium aurothiomalate is combined with Irinotecan.
Ramipril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Ramipril is combined with Sodium aurothiomalate.
Fosinopril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Fosinopril is combined with Sodium aurothiomalate.
Trandolapril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Trandolapril is combined with Sodium aurothiomalate.
Benazepril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Benazepril is combined with Sodium aurothiomalate.
Enalapril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Enalapril is combined with Sodium aurothiomalate.
Moexipril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Moexipril is combined with Sodium aurothiomalate.
Lisinopril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Lisinopril is combined with Sodium aurothiomalate.
Perindopril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Perindopril is combined with Sodium aurothiomalate.
Quinapril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Quinapril is combined with Sodium aurothiomalate.
Omapatrilat The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Omapatrilat is combined with Sodium aurothiomalate.
Rescinnamine The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Rescinnamine is combined with Sodium aurothiomalate.
Captopril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Captopril is combined with Sodium aurothiomalate.
Cilazapril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Cilazapril is combined with Sodium aurothiomalate.
Spirapril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Spirapril is combined with Sodium aurothiomalate.
Temocapril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Temocapril is combined with Sodium aurothiomalate.
Enalaprilat The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Enalaprilat is combined with Sodium aurothiomalate.
Imidapril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Imidapril is combined with Sodium aurothiomalate.
Zofenopril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Zofenopril is combined with Sodium aurothiomalate.
Delapril The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Delapril is combined with Sodium aurothiomalate.
Benazeprilat The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Benazeprilat is combined with Sodium aurothiomalate.
Fosinoprilat The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Fosinoprilat is combined with Sodium aurothiomalate.
Ramiprilat The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Ramiprilat is combined with Sodium aurothiomalate.
Trandolaprilat The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Trandolaprilat is combined with Sodium aurothiomalate.
Moexiprilat The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Moexiprilat is combined with Sodium aurothiomalate.
Perindoprilat The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Perindoprilat is combined with Sodium aurothiomalate.
Quinaprilat The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Quinaprilat is combined with Sodium aurothiomalate.
Cilazaprilat The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Cilazaprilat is combined with Sodium aurothiomalate.
Cyclosporine Cyclosporine may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18523733
    Kean WF, Kean IR: Clinical pharmacology of gold. Inflammopharmacology. 2008 Jun;16(3):112-25. doi: 10.1007/s10787-007-0021-x.
  • PMID: 9783766
    Jessop JD, O'Sullivan MM, Lewis PA, Williams LA, Camilleri JP, Plant MJ, Coles EC: A long-term five-year randomized controlled trial of hydroxychloroquine, sodium aurothiomalate, auranofin and penicillamine in the treatment of patients with rheumatoid arthritis. Br J Rheumatol. 1998 Sep;37(9):992-1002.

Contoh Produk & Brand

Produk: 7 • International brands: 1
Produk
  • Myochrysine
    Injection • 50 mg/1mL • Intramuscular • US
  • Myochrysine
    Solution • 50 mg / mL • Intramuscular • Canada • Approved
  • Myochrysine
    Solution • 25 mg / mL • Intramuscular • Canada • Approved
  • Myochrysine
    Solution • 10 mg / mL • Intramuscular • Canada • Approved
  • Sodium Aurothiomalate Injection BP
    Solution • 50 mg / mL • Intramuscular • Canada • Approved
  • Sodium Aurothiomalate Injection BP
    Solution • 10 mg / mL • Intramuscular • Canada • Approved
  • Sodium Aurothiomalate Injection BP
    Solution • 25 mg / mL • Intramuscular • Canada • Approved
International Brands
  • Myocrisin

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