Bismuth subcitrate potassium

DB09275

small molecule approved investigational

Deskripsi

A bismuth compound used for peptic ulcer and gastro-oesophageal reflux disease (GORD).

Struktur Molekul 2D

Berat 780.654
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The elimination half-life of bismuth is approximately 5 days
Volume Distribusi -
Klirens (Clearance) The rate of renal elimination appears to reach steady state 2 weeks after treatment discontinuation with similar rates of elimination at 6 weeks after discontinuation. The average urinary elimination of bismuth is 2.6% per day in the first two weeks after discontinuation (urine drug concentrations 24 to 250 mcg/mL) suggesting tissue accumulation and slow elimination.

Absorpsi

The mean peak whole-blood bismuth level after ingestion of colloidal bismuth subcitrate (214 mg bismuth) was more than 50 mg/liter and occurred at 30 minutes. After ingestion of bismuth subnitrate (205 mg bismuth), however, there was no evidence of bismuth absorption into blood, although in three of the volunteers who took bismuth subnitrate a week after colloidal bismuth subcitrate, baseline levels of blood bismuth were still elevated. Forty-five minutes after taking colloidal bismuth subcitrate, mean plasma levels for all five volunteers were also assessed and were 79.76 microg/liter as compared to blood levels of 47.6 microg/liter.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Elimination of bismuth is primarily through urinary and biliary routes.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Avoid ingesting alcohol during therapy with Pylera and for three days after discontinuation as it may cause flushing, nausea, and vomiting.
  • 2. Take after a meal. The overall exposure to bismuth subcitrate potassium was not significantly impacted by administration with food when tested in the combination product Pylera.

Interaksi Obat

154 Data
Doxycycline The serum concentration of Doxycycline can be decreased when it is combined with Bismuth subcitrate potassium.
Lymecycline The serum concentration of Lymecycline can be decreased when it is combined with Bismuth subcitrate potassium.
Clomocycline The serum concentration of Clomocycline can be decreased when it is combined with Bismuth subcitrate potassium.
Tigecycline The serum concentration of Tigecycline can be decreased when it is combined with Bismuth subcitrate potassium.
Oxytetracycline The serum concentration of Oxytetracycline can be decreased when it is combined with Bismuth subcitrate potassium.
Demeclocycline The serum concentration of Demeclocycline can be decreased when it is combined with Bismuth subcitrate potassium.
Metacycline The serum concentration of Metacycline can be decreased when it is combined with Bismuth subcitrate potassium.
Minocycline The serum concentration of Minocycline can be decreased when it is combined with Bismuth subcitrate potassium.
Rolitetracycline The serum concentration of Rolitetracycline can be decreased when it is combined with Bismuth subcitrate potassium.
Sarecycline The serum concentration of Sarecycline can be decreased when it is combined with Bismuth subcitrate potassium.
Eravacycline The serum concentration of Eravacycline can be decreased when it is combined with Bismuth subcitrate potassium.
Omadacycline The serum concentration of Omadacycline can be decreased when it is combined with Bismuth subcitrate potassium.
Penimepicycline The serum concentration of Penimepicycline can be decreased when it is combined with Bismuth subcitrate potassium.
Bismuth subsalicylate Bismuth subsalicylate may increase the neurotoxic activities of Bismuth subcitrate potassium.
Bismuth subcarbonate Bismuth subcitrate potassium may increase the neurotoxic activities of Bismuth subcarbonate.
Bismuth subnitrate Bismuth subcitrate potassium may increase the neurotoxic activities of Bismuth subnitrate.
Bismuth subgallate Bismuth subcitrate potassium may increase the neurotoxic activities of Bismuth subgallate.
Valproate bismuth Bismuth subcitrate potassium may increase the neurotoxic activities of Valproate bismuth.
Cyclosporine Cyclosporine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Succinylcholine Succinylcholine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Reserpine Reserpine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Ziprasidone Ziprasidone may increase the neurotoxic activities of Bismuth subcitrate potassium.
Cycloserine Cycloserine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Amitriptyline Amitriptyline may increase the neurotoxic activities of Bismuth subcitrate potassium.
Protriptyline Protriptyline may increase the neurotoxic activities of Bismuth subcitrate potassium.
Vinorelbine Vinorelbine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Clozapine Clozapine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Thiethylperazine Thiethylperazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Sulpiride Sulpiride may increase the neurotoxic activities of Bismuth subcitrate potassium.
Loxapine Loxapine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Remoxipride Remoxipride may increase the neurotoxic activities of Bismuth subcitrate potassium.
Promazine Promazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Prochlorperazine Prochlorperazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Teniposide Teniposide may increase the neurotoxic activities of Bismuth subcitrate potassium.
Droperidol Droperidol may increase the neurotoxic activities of Bismuth subcitrate potassium.
Imipramine Imipramine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Chlorpromazine Chlorpromazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Haloperidol Haloperidol may increase the neurotoxic activities of Bismuth subcitrate potassium.
Triflupromazine Triflupromazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Cyclophosphamide Cyclophosphamide may increase the neurotoxic activities of Bismuth subcitrate potassium.
Nortriptyline Nortriptyline may increase the neurotoxic activities of Bismuth subcitrate potassium.
Vincristine Vincristine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Amoxapine Amoxapine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Fluphenazine Fluphenazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Stavudine Stavudine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Thioridazine Thioridazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Moricizine Moricizine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Trimipramine Trimipramine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Risperidone Risperidone may increase the neurotoxic activities of Bismuth subcitrate potassium.
Trifluoperazine Trifluoperazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Perphenazine Perphenazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Flupentixol Flupentixol may increase the neurotoxic activities of Bismuth subcitrate potassium.
Ethanol Ethanol may increase the neurotoxic activities of Bismuth subcitrate potassium.
Didanosine Didanosine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Cyclobenzaprine Cyclobenzaprine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Mesoridazine Mesoridazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Acetophenazine Acetophenazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Promethazine Promethazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Pimozide Pimozide may increase the neurotoxic activities of Bismuth subcitrate potassium.
Doxepin Doxepin may increase the neurotoxic activities of Bismuth subcitrate potassium.
Desipramine Desipramine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Clindamycin Clindamycin may increase the neurotoxic activities of Bismuth subcitrate potassium.
Tubocurarine Tubocurarine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Paclitaxel Paclitaxel may increase the neurotoxic activities of Bismuth subcitrate potassium.
Aripiprazole Aripiprazole may increase the neurotoxic activities of Bismuth subcitrate potassium.
Chlorprothixene Chlorprothixene may increase the neurotoxic activities of Bismuth subcitrate potassium.
Clomipramine Clomipramine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Decamethonium Decamethonium may increase the neurotoxic activities of Bismuth subcitrate potassium.
Alimemazine Alimemazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Paliperidone Paliperidone may increase the neurotoxic activities of Bismuth subcitrate potassium.
Lithium cation Lithium cation may increase the neurotoxic activities of Bismuth subcitrate potassium.
Methotrimeprazine Methotrimeprazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Imipenem Imipenem may increase the neurotoxic activities of Bismuth subcitrate potassium.
Periciazine Periciazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Acepromazine Acepromazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Aceprometazine Aceprometazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Molindone Molindone may increase the neurotoxic activities of Bismuth subcitrate potassium.
Pipotiazine Pipotiazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Thioproperazine Thioproperazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Thiothixene Thiothixene may increase the neurotoxic activities of Bismuth subcitrate potassium.
Zuclopenthixol Zuclopenthixol may increase the neurotoxic activities of Bismuth subcitrate potassium.
Lincomycin Lincomycin may increase the neurotoxic activities of Bismuth subcitrate potassium.
Amineptine Amineptine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Fluspirilene Fluspirilene may increase the neurotoxic activities of Bismuth subcitrate potassium.
Osanetant Osanetant may increase the neurotoxic activities of Bismuth subcitrate potassium.
Bifeprunox Bifeprunox may increase the neurotoxic activities of Bismuth subcitrate potassium.
Iloperidone Iloperidone may increase the neurotoxic activities of Bismuth subcitrate potassium.
Pimavanserin Pimavanserin may increase the neurotoxic activities of Bismuth subcitrate potassium.
BL-1020 BL-1020 may increase the neurotoxic activities of Bismuth subcitrate potassium.
Cariprazine Cariprazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Sertindole Sertindole may increase the neurotoxic activities of Bismuth subcitrate potassium.
Asenapine Asenapine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Amisulpride Amisulpride may increase the neurotoxic activities of Bismuth subcitrate potassium.
Lurasidone Lurasidone may increase the neurotoxic activities of Bismuth subcitrate potassium.
Perospirone Perospirone may increase the neurotoxic activities of Bismuth subcitrate potassium.
Amperozide Amperozide may increase the neurotoxic activities of Bismuth subcitrate potassium.
Dimetacrine Dimetacrine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Cyamemazine Cyamemazine may increase the neurotoxic activities of Bismuth subcitrate potassium.
Butriptyline Butriptyline may increase the neurotoxic activities of Bismuth subcitrate potassium.
Brexpiprazole Brexpiprazole may increase the neurotoxic activities of Bismuth subcitrate potassium.

Target Protein

ATP-dependent Clp protease ATP-binding subunit ClpX clpX

Referensi & Sumber

Artikel (PubMed)
  • PMID: 1957120
    Lee SP: The mode of action of colloidal bismuth subcitrate. Scand J Gastroenterol Suppl. 1991;185:1-6.
  • PMID: 3053124
    Wagstaff AJ, Benfield P, Monk JP: Colloidal bismuth subcitrate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in peptic ulcer disease. Drugs. 1988 Aug;36(2):132-57.
  • PMID: 10971684
    Phillips RH, Whitehead MW, Lacey S, Champion M, Thompson RP, Powell JJ: Solubility, absorption, and anti-Helicobacter pylori activity of bismuth subnitrate and colloidal bismuth subcitrate: In vitro data Do not predict In vivo efficacy. Helicobacter. 2000 Sep;5(3):176-82.
Link

Contoh Produk & Brand

Produk: 8 • International brands: 0
Produk
  • Bismuth Subcitrate Potassium, Metronidazole and Tetracycline Hydrochloride
    Capsule • - • Oral • US • Generic • Approved
  • Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Hydrochloride
    Capsule • - • Oral • US • Approved
  • Bismuth subcitrate potassium, Metronidazole, Tetracycline hydrochloride
    Capsule • - • Oral • US • Generic • Approved
  • Pylera
    Capsule • - • Oral • US • Approved
  • Pylera
    Capsule • - • Oral • US • Approved
  • Pylera
    Capsule • - • Oral • US • Approved
  • Pylera
    Capsule • - • Oral • Canada • Approved
  • Pylera
    Capsule • - • Oral • US • Approved

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