Peringatan Keamanan

The acute oral LD50 in rats has been documented to be >5000 mg/kg.L50216

Phenylacetic acid

DB09269

small molecule approved

Deskripsi

Phenylacetic acid is an organic compound containing a phenyl functional group and a carboxylic acid functional group. It is a white solid with a disagreeable odor. Because it is used in the illicit production of phenylacetone (used in the manufacture of substituted amphetamines), it is subject to controls in countries including the United States and China.

Struktur Molekul 2D

Berat 136.1479
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi 19.2 ± 3.3 L.
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Phenylacetate esterases found in the human liver cytosol. Human plasma esterase also hydrolyze phenylacetate. Phenylacetate hydrolysis involved arylesterase in plasma, both arylesterase and carboxylesterase in liver microsomes and carboxylesterase in liver cytosol. Plasma hydrolysis is less important and overall esterase activity is lower in humans than in the rat.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

65 Data
Haloperidol The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Haloperidol.
Valproic acid The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Valproic acid.
Flunisolide The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Flunisolide.
Beclomethasone dipropionate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Beclomethasone dipropionate.
Betamethasone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Betamethasone.
Fluticasone propionate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluticasone propionate.
Fluocinolone acetonide The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluocinolone acetonide.
Triamcinolone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Triamcinolone.
Prednisone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Prednisone.
Fludrocortisone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fludrocortisone.
Hydrocortisone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Hydrocortisone.
Prednisolone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Prednisolone.
Methylprednisolone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Methylprednisolone.
Trilostane The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Trilostane.
Budesonide The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Budesonide.
Dexamethasone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Dexamethasone.
Corticotropin The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Corticotropin.
Cortisone acetate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Cortisone acetate.
Paramethasone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Paramethasone.
Ciclesonide The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Ciclesonide.
Aldosterone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Aldosterone.
Fluticasone furoate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluticasone furoate.
Fluprednidene The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluprednidene.
Tixocortol The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Tixocortol.
Fluprednisolone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluprednisolone.
Meprednisone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Meprednisone.
Dexamethasone isonicotinate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Dexamethasone isonicotinate.
Melengestrol The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Melengestrol.
Deflazacort The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Deflazacort.
Cortivazol The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Cortivazol.
Prednylidene The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Prednylidene.
Fluocortin The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluocortin.
Fluperolone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluperolone.
Cloprednol The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Cloprednol.
Fluclorolone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluclorolone.
Fluticasone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluticasone.
Mometasone furoate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Mometasone furoate.
Hydrocortisone acetate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Hydrocortisone acetate.
Hydrocortisone cypionate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Hydrocortisone cypionate.
Hydrocortisone succinate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Hydrocortisone succinate.
Prednisolone phosphate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Prednisolone phosphate.
Prednisolone hemisuccinate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Prednisolone hemisuccinate.
Methylprednisolone hemisuccinate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Methylprednisolone hemisuccinate.
Prednisone acetate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Prednisone acetate.
Clocortolone acetate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Clocortolone acetate.
Melengestrol acetate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Melengestrol acetate.
Betamethasone phosphate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Betamethasone phosphate.
Cortisone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Cortisone.
Clobetasol propionate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Clobetasol propionate.
Fluocinonide The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluocinonide.
Hydrocortisone butyrate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Hydrocortisone butyrate.
Desoximetasone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Desoximetasone.
Mometasone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Mometasone.
Fluocortolone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluocortolone.
Prednisolone acetate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Prednisolone acetate.
Fluorometholone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluorometholone.
Difluocortolone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Difluocortolone.
Flumethasone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Flumethasone.
Methylprednisolone aceponate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Methylprednisolone aceponate.
Dexamethasone acetate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Dexamethasone acetate.
Corticotropin zinc hydroxide The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Corticotropin zinc hydroxide.
Fluocortolone pivalate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluocortolone pivalate.
Fluocortolone caproate The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluocortolone caproate.
Desoxycortone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Desoxycortone.
Vamorolone The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Vamorolone.

Contoh Produk & Brand

Produk: 16 • International brands: 0
Produk
  • Ammonul
    Injection, solution, concentrate • - • Intravenous • US • Approved
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    Injection, solution, concentrate • - • Intravenous • US • Approved
  • Ammonul
    Injection, solution, concentrate • - • Intravenous • US • Approved
  • Sodium Phenylacetate and Sodium Benzoate
    Injection, solution, concentrate • - • Intravenous • US • Generic • Approved
  • Sodium Phenylacetate and Sodium Benzoate
    Injection, solution, concentrate • - • Intravenous • US • Generic • Approved
  • Sodium Phenylacetate and Sodium Benzoate
    Injection, solution, concentrate • - • Intravenous • US • Generic • Approved
  • SODIUM PHENYLACETATE and SODIUM BENZOATE
    Injection, solution, concentrate • - • Intravenous • US • Generic • Approved
  • SODIUM PHENYLACETATE and SODIUM BENZOATE
    Injection, solution, concentrate • - • Intravenous • US • Generic • Approved
Menampilkan 8 dari 16 produk.

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