Peringatan Keamanan

Overdosage of laxative preparations containing sodium picosulfate may lead to severe electrolyte disturbances, in addition to dehydration and hypovolemia, with signs and symptoms of these disturbances. In case of overdose, monitor for fluid and electrolyte disturbances with symptomatic treatment.^L43832 In vitro, 800 and 1600 mg/mL of sodium picosulfate exerted cytotoxic effects on cultured liver cells by inducing dose-dependent vacuolic and fatty change, as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit.^A18754

Picosulfuric acid

DB09268

small molecule approved

Deskripsi

Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been used in European countries for many years.^A33322

Struktur Molekul 2D

Berat 437.44

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) The terminal half-life of sodium picosulfate is 7.4 hours in adults and 7 hours in pediatric patients.[L43832]

Volume Distribusi Not available.

Klirens (Clearance) Not available.

Absorpsi

After the first dose of an oral sodium picosulfate, magnesium oxide, and anhydrous citric acid product, healthy volunteers had a picosulfate mean peak plasma concentration (C_max) of 2.3 ng/mL that was reached at 2 hours (t_max). After the administration of two doses separated by 6 hours, the mean C_max for picosulfate was 3.2 ng/mL, with a t_max of 7 hours.L43832,F135

Metabolisme

Sodium picosulfate is hydrolyzed by colonic bacteria to form an active metabolite bis-(p-hydroxy-phenyl)-pyridyl-2-methane (BHPM).^L43832

Rute Eliminasi

Sodium picosulfate and its metabolite bis-(p-hydroxy-phenyl)-pyridyl-2-methane (BHPM) are mainly excreted in urine. The majority of BHPM is excreted as a glucuronide-conjugate. Approximately 0.1% of the sodium picosulfate dose is excreted unchanged in urine.^L43832

Interaksi Makanan

2 Data

1. Avoid alcohol.
2. Avoid solid foods. When using picosulfuric acid in preparation for a colonoscopy, only consume clear fluids the day before the procedure.

Interaksi Obat

1209 Data

Erythromycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Erythromycin.
Azithromycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Azithromycin.
Moxifloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Moxifloxacin.
Cefotiam	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefotiam.
Aminosalicylic acid	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Aminosalicylic acid.
Dapsone	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dapsone.
Doxycycline	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Doxycycline.
Lymecycline	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lymecycline.
Cycloserine	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cycloserine.
Sulfisoxazole	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfisoxazole.
Cefmenoxime	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefmenoxime.
Flucloxacillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Flucloxacillin.
Ethambutol	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ethambutol.
Pyrazinamide	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pyrazinamide.
Sulfadiazine	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfadiazine.
Grepafloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Grepafloxacin.
Ampicillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ampicillin.
Phenoxymethylpenicillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Phenoxymethylpenicillin.
Cefpiramide	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefpiramide.
Chloramphenicol	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Chloramphenicol.
Loracarbef	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Loracarbef.
Framycetin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Framycetin.
Clomocycline	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clomocycline.
Enoxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Enoxacin.
Dicloxacillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dicloxacillin.
Pefloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pefloxacin.
Vancomycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Vancomycin.
Cefdinir	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefdinir.
Ciprofloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ciprofloxacin.
Cephalexin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cephalexin.
Carbenicillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Carbenicillin.
Oxytetracycline	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Oxytetracycline.
Linezolid	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Linezolid.
Ethionamide	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ethionamide.
Rifabutin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifabutin.
Demeclocycline	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Demeclocycline.
Bacitracin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Bacitracin.
Cefixime	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefixime.
Tobramycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tobramycin.
Trovafloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Trovafloxacin.
Mycophenolate mofetil	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Mycophenolate mofetil.
Cephaloglycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cephaloglycin.
Nitrofurantoin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Nitrofurantoin.
Hetacillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Hetacillin.
Tetracycline	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tetracycline.
Clavulanic acid	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clavulanic acid.
Roxithromycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Roxithromycin.
Nalidixic acid	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Nalidixic acid.
Rosoxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rosoxacin.
Cinoxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cinoxacin.
Fosfomycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fosfomycin.
Cefaclor	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefaclor.
Clofazimine	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clofazimine.
Sirolimus	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sirolimus.
Tinidazole	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tinidazole.
Metronidazole	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Metronidazole.
Ceforanide	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceforanide.
Metacycline	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Metacycline.
Isoniazid	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Isoniazid.
Dirithromycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dirithromycin.
Telithromycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Telithromycin.
Lomefloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lomefloxacin.
Neomycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Neomycin.
Cyclacillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cyclacillin.
Sulfamethoxazole	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfamethoxazole.
Minocycline	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Minocycline.
Mycophenolic acid	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Mycophenolic acid.
Gatifloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gatifloxacin.
Rifampin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifampicin.
Novobiocin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Novobiocin.
Benzylpenicillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Benzylpenicillin.
Norfloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Norfloxacin.
Amoxicillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Amoxicillin.
Azlocillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Azlocillin.
Cefditoren	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefditoren.
Cefuroxime	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefuroxime.
Levofloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Levofloxacin.
Cefapirin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefapirin.
Cefadroxil	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefadroxil.
Cloxacillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cloxacillin.
Cefprozil	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefprozil.
Candicidin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Candicidin.
Gemifloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gemifloxacin.
Amdinocillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Amdinocillin.
Ofloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ofloxacin.
Clindamycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clindamycin.
Rifapentine	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifapentine.
Sparfloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sparfloxacin.
Clarithromycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clarithromycin.
Rifaximin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifaximin.
Josamycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Josamycin.
Cefradine	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefradine.
Temafloxacin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Temafloxacin.
Ceftibuten	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceftibuten.
Cefpodoxime	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefpodoxime.
Paromomycin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Paromomycin.
Sulfamerazine	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfamerazine.
Everolimus	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Everolimus.
Bacampicillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Bacampicillin.
Meticillin	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Meticillin.

Referensi & Sumber

Artikel (PubMed)

PMID: 7194649
Nishikawa J, Kast A: Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man. Arzneimittelforschung. 1981;31(2):321-5.
PMID: 1507649
Kim DH, Hyun SH, Shim SB, Kobashi K: The role of intestinal bacteria in the transformation of sodium picosulfate. Jpn J Pharmacol. 1992 May;59(1):1-5.
PMID: 19826647
Love J, Bernard EJ, Cockeram A, Cohen L, Fishman M, Gray J, Morgan D: A multicentre, observational study of sodium picosulfate and magnesium citrate as a precolonoscopy bowel preparation. Can J Gastroenterol. 2009 Oct;23(10):706-10.

Link

FDA Approved Drug Products: CLENPIQ (sodium picosulfate, magnesium oxide, and anhydrous citric acid) oral solution

Attachment

FDA Clinical Pharmacology and Biopharmaceutical Review(s) on PICOPREP

Contoh Produk & Brand

Produk: 12 • International brands: 5

Produk

Citracleen

Powder, for solution • - • Oral • Canada • Approved
Clenpiq

Liquid • - • Oral • US • Approved
Clenpiq

Liquid • - • Oral • US • Approved
Clenpiq

Liquid • - • Oral • US • Approved
Oral Purgative

Powder, for solution • - • Oral • Canada • Approved
Pico-salax

Powder, for solution • - • Oral • Canada • Approved
Picodan

Powder, for solution • - • Oral • Canada • Approved
Picoflo

Powder, for solution • - • Oral • Canada • Approved

Menampilkan 8 dari 12 produk.

International Brands

Guttalax
Laxoberal
Laxoberon
Picolax
Picoprep

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.