Safrazine

DB09253

small molecule withdrawn

Deskripsi

Safrazine is a member of the hydrazine family with non-selective and irreversible inhibitor effects against monoamine oxidases. In 1960, it was used as an antidepressant but it is now discontinued.

Struktur Molekul 2D

Berat 208.261
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1325 Data
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Safrazine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Safrazine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Safrazine.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Safrazine.
Magnesium sulfate The therapeutic efficacy of Safrazine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Safrazine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Safrazine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Safrazine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Safrazine.
Orphenadrine Safrazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Safrazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Safrazine.
Pramipexole Safrazine may increase the sedative activities of Pramipexole.
Ropinirole Safrazine may increase the sedative activities of Ropinirole.
Rotigotine Safrazine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Safrazine.
Sodium oxybate Safrazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Safrazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Thalidomide Safrazine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Safrazine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Safrazine.
Cyclosporine The risk or severity of hypertension can be increased when Cyclosporine is combined with Safrazine.
Icosapent The risk or severity of hypertension can be increased when Icosapent is combined with Safrazine.
Mesalazine The risk or severity of hypertension can be increased when Mesalazine is combined with Safrazine.
Indomethacin The risk or severity of hypertension can be increased when Indomethacin is combined with Safrazine.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Safrazine.
Nabumetone The risk or severity of hypertension can be increased when Nabumetone is combined with Safrazine.
Ketorolac The risk or severity of hypertension can be increased when Ketorolac is combined with Safrazine.
Tenoxicam The risk or severity of hypertension can be increased when Tenoxicam is combined with Safrazine.
Celecoxib The risk or severity of hypertension can be increased when Celecoxib is combined with Safrazine.
Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Safrazine.
Rofecoxib The risk or severity of hypertension can be increased when Rofecoxib is combined with Safrazine.
Piroxicam The risk or severity of hypertension can be increased when Piroxicam is combined with Safrazine.
Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Safrazine.
Valdecoxib The risk or severity of hypertension can be increased when Valdecoxib is combined with Safrazine.
Diclofenac The risk or severity of hypertension can be increased when Diclofenac is combined with Safrazine.
Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Safrazine.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Safrazine.
Flurbiprofen The risk or severity of hypertension can be increased when Flurbiprofen is combined with Safrazine.
Etodolac The risk or severity of hypertension can be increased when Etodolac is combined with Safrazine.
Mefenamic acid The risk or severity of hypertension can be increased when Mefenamic acid is combined with Safrazine.
Naproxen The risk or severity of hypertension can be increased when Naproxen is combined with Safrazine.
Sulfasalazine The risk or severity of hypertension can be increased when Sulfasalazine is combined with Safrazine.
Phenylbutazone The risk or severity of hypertension can be increased when Phenylbutazone is combined with Safrazine.
Meloxicam The risk or severity of hypertension can be increased when Meloxicam is combined with Safrazine.
Carprofen The risk or severity of hypertension can be increased when Carprofen is combined with Safrazine.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Safrazine.
Diflunisal The risk or severity of hypertension can be increased when Diflunisal is combined with Safrazine.
Salicylic acid The risk or severity of hypertension can be increased when Salicylic acid is combined with Safrazine.
Meclofenamic acid The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Safrazine.
Dopamine The risk or severity of hypertension can be increased when Dopamine is combined with Safrazine.
Oxaprozin The risk or severity of hypertension can be increased when Oxaprozin is combined with Safrazine.
Ketoprofen The risk or severity of hypertension can be increased when Ketoprofen is combined with Safrazine.
Balsalazide The risk or severity of hypertension can be increased when Balsalazide is combined with Safrazine.
Ibuprofen The risk or severity of hypertension can be increased when Ibuprofen is combined with Safrazine.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Safrazine.
Propafenone The risk or severity of hypertension can be increased when Propafenone is combined with Safrazine.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Safrazine.
Lumiracoxib The risk or severity of hypertension can be increased when Lumiracoxib is combined with Safrazine.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Safrazine.
Magnesium salicylate The risk or severity of hypertension can be increased when Magnesium salicylate is combined with Safrazine.
Salsalate The risk or severity of hypertension can be increased when Salsalate is combined with Safrazine.
Choline magnesium trisalicylate The risk or severity of hypertension can be increased when Choline magnesium trisalicylate is combined with Safrazine.
Antrafenine The risk or severity of hypertension can be increased when Antrafenine is combined with Safrazine.
Aminophenazone The risk or severity of hypertension can be increased when Aminophenazone is combined with Safrazine.
Antipyrine The risk or severity of hypertension can be increased when Antipyrine is combined with Safrazine.
Tiaprofenic acid The risk or severity of hypertension can be increased when Tiaprofenic acid is combined with Safrazine.
Etoricoxib The risk or severity of hypertension can be increased when Etoricoxib is combined with Safrazine.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Safrazine.
Taxifolin The risk or severity of hypertension can be increased when Taxifolin is combined with Safrazine.
Oxyphenbutazone The risk or severity of hypertension can be increased when Oxyphenbutazone is combined with Safrazine.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Safrazine.
Benoxaprofen The risk or severity of hypertension can be increased when Benoxaprofen is combined with Safrazine.
Metamizole The risk or severity of hypertension can be increased when Metamizole is combined with Safrazine.
Zomepirac The risk or severity of hypertension can be increased when Zomepirac is combined with Safrazine.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Safrazine.
Cimicoxib The risk or severity of hypertension can be increased when Cimicoxib is combined with Safrazine.
Amibegron The risk or severity of hypertension can be increased when Amibegron is combined with Safrazine.
Nylidrin The risk or severity of hypertension can be increased when Nylidrin is combined with Safrazine.
Solabegron The risk or severity of hypertension can be increased when Solabegron is combined with Safrazine.
Lornoxicam The risk or severity of hypertension can be increased when Lornoxicam is combined with Safrazine.
Aceclofenac The risk or severity of hypertension can be increased when Aceclofenac is combined with Safrazine.
Zaltoprofen The risk or severity of hypertension can be increased when Zaltoprofen is combined with Safrazine.
Saralasin The risk or severity of hypertension can be increased when Saralasin is combined with Safrazine.
Azapropazone The risk or severity of hypertension can be increased when Azapropazone is combined with Safrazine.
Parecoxib The risk or severity of hypertension can be increased when Parecoxib is combined with Safrazine.
Salicylamide The risk or severity of hypertension can be increased when Salicylamide is combined with Safrazine.
Tyramine The risk or severity of hypertension can be increased when Tyramine is combined with Safrazine.
Mirabegron The risk or severity of hypertension can be increased when Mirabegron is combined with Safrazine.
Adrafinil The risk or severity of hypertension can be increased when Adrafinil is combined with Safrazine.
Kebuzone The risk or severity of hypertension can be increased when Kebuzone is combined with Safrazine.
Isoxicam The risk or severity of hypertension can be increased when Isoxicam is combined with Safrazine.
Indoprofen The risk or severity of hypertension can be increased when Indoprofen is combined with Safrazine.
Ibuproxam The risk or severity of hypertension can be increased when Ibuproxam is combined with Safrazine.
Floctafenine The risk or severity of hypertension can be increased when Floctafenine is combined with Safrazine.
Fenbufen The risk or severity of hypertension can be increased when Fenbufen is combined with Safrazine.
Etofenamate The risk or severity of hypertension can be increased when Etofenamate is combined with Safrazine.
Etilefrine The risk or severity of hypertension can be increased when Etilefrine is combined with Safrazine.
Epirizole The risk or severity of hypertension can be increased when Epirizole is combined with Safrazine.
Benzydamine The risk or severity of hypertension can be increased when Benzydamine is combined with Safrazine.

Referensi & Sumber

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