Pivhydrazine

DB09252

small molecule withdrawn

Deskripsi

Pivhydrazine, also known as pivazide, is a member of the hydrazine family with irreversible and non-selective inhibitory activity against monoamine oxidases. In 1960, it was widely used as an antidepressant agent but it is now discontinued.

Struktur Molekul 2D

Berat 206.289
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1322 Data
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pivhydrazine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Pivhydrazine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Pivhydrazine.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pivhydrazine.
Magnesium sulfate The therapeutic efficacy of Pivhydrazine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Pivhydrazine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Pivhydrazine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Pivhydrazine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Pivhydrazine.
Orphenadrine Pivhydrazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Pivhydrazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Pivhydrazine.
Pramipexole Pivhydrazine may increase the sedative activities of Pramipexole.
Ropinirole Pivhydrazine may increase the sedative activities of Ropinirole.
Rotigotine Pivhydrazine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Pivhydrazine.
Sodium oxybate Pivhydrazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Pivhydrazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Thalidomide Pivhydrazine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Pivhydrazine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Pivhydrazine.
Cyclosporine The risk or severity of hypertension can be increased when Cyclosporine is combined with Pivhydrazine.
Icosapent The risk or severity of hypertension can be increased when Icosapent is combined with Pivhydrazine.
Mesalazine The risk or severity of hypertension can be increased when Mesalazine is combined with Pivhydrazine.
Indomethacin The risk or severity of hypertension can be increased when Indomethacin is combined with Pivhydrazine.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Pivhydrazine.
Nabumetone The risk or severity of hypertension can be increased when Nabumetone is combined with Pivhydrazine.
Ketorolac The risk or severity of hypertension can be increased when Ketorolac is combined with Pivhydrazine.
Tenoxicam The risk or severity of hypertension can be increased when Tenoxicam is combined with Pivhydrazine.
Celecoxib The risk or severity of hypertension can be increased when Celecoxib is combined with Pivhydrazine.
Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Pivhydrazine.
Rofecoxib The risk or severity of hypertension can be increased when Rofecoxib is combined with Pivhydrazine.
Piroxicam The risk or severity of hypertension can be increased when Piroxicam is combined with Pivhydrazine.
Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Pivhydrazine.
Valdecoxib The risk or severity of hypertension can be increased when Valdecoxib is combined with Pivhydrazine.
Diclofenac The risk or severity of hypertension can be increased when Diclofenac is combined with Pivhydrazine.
Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Pivhydrazine.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Pivhydrazine.
Flurbiprofen The risk or severity of hypertension can be increased when Flurbiprofen is combined with Pivhydrazine.
Etodolac The risk or severity of hypertension can be increased when Etodolac is combined with Pivhydrazine.
Mefenamic acid The risk or severity of hypertension can be increased when Mefenamic acid is combined with Pivhydrazine.
Naproxen The risk or severity of hypertension can be increased when Naproxen is combined with Pivhydrazine.
Sulfasalazine The risk or severity of hypertension can be increased when Sulfasalazine is combined with Pivhydrazine.
Phenylbutazone The risk or severity of hypertension can be increased when Phenylbutazone is combined with Pivhydrazine.
Meloxicam The risk or severity of hypertension can be increased when Meloxicam is combined with Pivhydrazine.
Carprofen The risk or severity of hypertension can be increased when Carprofen is combined with Pivhydrazine.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Pivhydrazine.
Diflunisal The risk or severity of hypertension can be increased when Diflunisal is combined with Pivhydrazine.
Salicylic acid The risk or severity of hypertension can be increased when Salicylic acid is combined with Pivhydrazine.
Meclofenamic acid The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Pivhydrazine.
Dopamine The risk or severity of hypertension can be increased when Dopamine is combined with Pivhydrazine.
Oxaprozin The risk or severity of hypertension can be increased when Oxaprozin is combined with Pivhydrazine.
Ketoprofen The risk or severity of hypertension can be increased when Ketoprofen is combined with Pivhydrazine.
Balsalazide The risk or severity of hypertension can be increased when Balsalazide is combined with Pivhydrazine.
Ibuprofen The risk or severity of hypertension can be increased when Ibuprofen is combined with Pivhydrazine.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Pivhydrazine.
Propafenone The risk or severity of hypertension can be increased when Propafenone is combined with Pivhydrazine.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Pivhydrazine.
Lumiracoxib The risk or severity of hypertension can be increased when Lumiracoxib is combined with Pivhydrazine.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Pivhydrazine.
Magnesium salicylate The risk or severity of hypertension can be increased when Magnesium salicylate is combined with Pivhydrazine.
Salsalate The risk or severity of hypertension can be increased when Salsalate is combined with Pivhydrazine.
Choline magnesium trisalicylate The risk or severity of hypertension can be increased when Choline magnesium trisalicylate is combined with Pivhydrazine.
Antrafenine The risk or severity of hypertension can be increased when Antrafenine is combined with Pivhydrazine.
Aminophenazone The risk or severity of hypertension can be increased when Aminophenazone is combined with Pivhydrazine.
Antipyrine The risk or severity of hypertension can be increased when Antipyrine is combined with Pivhydrazine.
Tiaprofenic acid The risk or severity of hypertension can be increased when Tiaprofenic acid is combined with Pivhydrazine.
Etoricoxib The risk or severity of hypertension can be increased when Etoricoxib is combined with Pivhydrazine.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Pivhydrazine.
Taxifolin The risk or severity of hypertension can be increased when Taxifolin is combined with Pivhydrazine.
Oxyphenbutazone The risk or severity of hypertension can be increased when Oxyphenbutazone is combined with Pivhydrazine.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Pivhydrazine.
Benoxaprofen The risk or severity of hypertension can be increased when Benoxaprofen is combined with Pivhydrazine.
Metamizole The risk or severity of hypertension can be increased when Metamizole is combined with Pivhydrazine.
Zomepirac The risk or severity of hypertension can be increased when Zomepirac is combined with Pivhydrazine.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Pivhydrazine.
Cimicoxib The risk or severity of hypertension can be increased when Cimicoxib is combined with Pivhydrazine.
Amibegron The risk or severity of hypertension can be increased when Amibegron is combined with Pivhydrazine.
Nylidrin The risk or severity of hypertension can be increased when Nylidrin is combined with Pivhydrazine.
Solabegron The risk or severity of hypertension can be increased when Solabegron is combined with Pivhydrazine.
Lornoxicam The risk or severity of hypertension can be increased when Lornoxicam is combined with Pivhydrazine.
Aceclofenac The risk or severity of hypertension can be increased when Aceclofenac is combined with Pivhydrazine.
Zaltoprofen The risk or severity of hypertension can be increased when Zaltoprofen is combined with Pivhydrazine.
Saralasin The risk or severity of hypertension can be increased when Saralasin is combined with Pivhydrazine.
Azapropazone The risk or severity of hypertension can be increased when Azapropazone is combined with Pivhydrazine.
Parecoxib The risk or severity of hypertension can be increased when Parecoxib is combined with Pivhydrazine.
Salicylamide The risk or severity of hypertension can be increased when Salicylamide is combined with Pivhydrazine.
Tyramine The risk or severity of hypertension can be increased when Tyramine is combined with Pivhydrazine.
Mirabegron The risk or severity of hypertension can be increased when Mirabegron is combined with Pivhydrazine.
Adrafinil The risk or severity of hypertension can be increased when Adrafinil is combined with Pivhydrazine.
Kebuzone The risk or severity of hypertension can be increased when Kebuzone is combined with Pivhydrazine.
Isoxicam The risk or severity of hypertension can be increased when Isoxicam is combined with Pivhydrazine.
Indoprofen The risk or severity of hypertension can be increased when Indoprofen is combined with Pivhydrazine.
Ibuproxam The risk or severity of hypertension can be increased when Ibuproxam is combined with Pivhydrazine.
Floctafenine The risk or severity of hypertension can be increased when Floctafenine is combined with Pivhydrazine.
Fenbufen The risk or severity of hypertension can be increased when Fenbufen is combined with Pivhydrazine.
Etofenamate The risk or severity of hypertension can be increased when Etofenamate is combined with Pivhydrazine.
Etilefrine The risk or severity of hypertension can be increased when Etilefrine is combined with Pivhydrazine.
Epirizole The risk or severity of hypertension can be increased when Epirizole is combined with Pivhydrazine.
Benzydamine The risk or severity of hypertension can be increased when Benzydamine is combined with Pivhydrazine.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 981020
    Herman ZS, Sokola A, Lenartowicz H, Zielinski M, Depta L: The influence of antidepressive drugs on the level of acetylcholine and on the acetylcholinesterase activity in the brain of rats. Pol J Pharmacol Pharm. 1976 May-Jun;28(4):313-21.
  • PMID: 43225
    Bolton GC, Griffiths LA: The metabolic disposition of 14Cpivhydrazine, 14Cmebanazine, and 14Cbenzylhydrazine in the rat. Drug Metab Dispos. 1979 Nov-Dec;7(6):388-92.
  • PMID: 5381593
    Mikhailova TV, Gilev AP, Khavronina-Gureeva ZP: Central effects of betamezide. Farmakol Toksikol. 1969 Nov-Dec;32(6):652-6.

Contoh Produk & Brand

Produk: 0 • International brands: 4
International Brands
  • Angorvid
  • Betamezid
  • Neomarsilid
  • Tersavid

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