Phenoxypropazine

DB09251

small molecule withdrawn

Deskripsi

Phenoxypropazine is a non-selective and irreversible monoamine oxidase enzyme inhibitor (MAOI), belonging to the hydrazine chemical class. It was marketed as an antidepressant in 1961 but was later withdrawn in 1966 because of its hepatotoxic potential.

Struktur Molekul 2D

Berat 166.224
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1322 Data
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenoxypropazine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Phenoxypropazine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Phenoxypropazine.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Phenoxypropazine.
Magnesium sulfate The therapeutic efficacy of Phenoxypropazine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Phenoxypropazine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Phenoxypropazine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Phenoxypropazine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Phenoxypropazine.
Orphenadrine Phenoxypropazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Phenoxypropazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Phenoxypropazine.
Pramipexole Phenoxypropazine may increase the sedative activities of Pramipexole.
Ropinirole Phenoxypropazine may increase the sedative activities of Ropinirole.
Rotigotine Phenoxypropazine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Phenoxypropazine.
Sodium oxybate Phenoxypropazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Phenoxypropazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Thalidomide Phenoxypropazine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Phenoxypropazine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Phenoxypropazine.
Cyclosporine The risk or severity of hypertension can be increased when Cyclosporine is combined with Phenoxypropazine.
Icosapent The risk or severity of hypertension can be increased when Icosapent is combined with Phenoxypropazine.
Mesalazine The risk or severity of hypertension can be increased when Mesalazine is combined with Phenoxypropazine.
Indomethacin The risk or severity of hypertension can be increased when Indomethacin is combined with Phenoxypropazine.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Phenoxypropazine.
Nabumetone The risk or severity of hypertension can be increased when Nabumetone is combined with Phenoxypropazine.
Ketorolac The risk or severity of hypertension can be increased when Ketorolac is combined with Phenoxypropazine.
Tenoxicam The risk or severity of hypertension can be increased when Tenoxicam is combined with Phenoxypropazine.
Celecoxib The risk or severity of hypertension can be increased when Celecoxib is combined with Phenoxypropazine.
Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Phenoxypropazine.
Rofecoxib The risk or severity of hypertension can be increased when Rofecoxib is combined with Phenoxypropazine.
Piroxicam The risk or severity of hypertension can be increased when Piroxicam is combined with Phenoxypropazine.
Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Phenoxypropazine.
Valdecoxib The risk or severity of hypertension can be increased when Valdecoxib is combined with Phenoxypropazine.
Diclofenac The risk or severity of hypertension can be increased when Diclofenac is combined with Phenoxypropazine.
Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Phenoxypropazine.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Phenoxypropazine.
Flurbiprofen The risk or severity of hypertension can be increased when Flurbiprofen is combined with Phenoxypropazine.
Etodolac The risk or severity of hypertension can be increased when Etodolac is combined with Phenoxypropazine.
Mefenamic acid The risk or severity of hypertension can be increased when Mefenamic acid is combined with Phenoxypropazine.
Naproxen The risk or severity of hypertension can be increased when Naproxen is combined with Phenoxypropazine.
Sulfasalazine The risk or severity of hypertension can be increased when Sulfasalazine is combined with Phenoxypropazine.
Phenylbutazone The risk or severity of hypertension can be increased when Phenylbutazone is combined with Phenoxypropazine.
Meloxicam The risk or severity of hypertension can be increased when Meloxicam is combined with Phenoxypropazine.
Carprofen The risk or severity of hypertension can be increased when Carprofen is combined with Phenoxypropazine.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Phenoxypropazine.
Diflunisal The risk or severity of hypertension can be increased when Diflunisal is combined with Phenoxypropazine.
Salicylic acid The risk or severity of hypertension can be increased when Salicylic acid is combined with Phenoxypropazine.
Meclofenamic acid The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Phenoxypropazine.
Dopamine The risk or severity of hypertension can be increased when Dopamine is combined with Phenoxypropazine.
Oxaprozin The risk or severity of hypertension can be increased when Oxaprozin is combined with Phenoxypropazine.
Ketoprofen The risk or severity of hypertension can be increased when Ketoprofen is combined with Phenoxypropazine.
Balsalazide The risk or severity of hypertension can be increased when Balsalazide is combined with Phenoxypropazine.
Ibuprofen The risk or severity of hypertension can be increased when Ibuprofen is combined with Phenoxypropazine.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Phenoxypropazine.
Propafenone The risk or severity of hypertension can be increased when Propafenone is combined with Phenoxypropazine.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Phenoxypropazine.
Lumiracoxib The risk or severity of hypertension can be increased when Lumiracoxib is combined with Phenoxypropazine.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Phenoxypropazine.
Magnesium salicylate The risk or severity of hypertension can be increased when Magnesium salicylate is combined with Phenoxypropazine.
Salsalate The risk or severity of hypertension can be increased when Salsalate is combined with Phenoxypropazine.
Choline magnesium trisalicylate The risk or severity of hypertension can be increased when Choline magnesium trisalicylate is combined with Phenoxypropazine.
Antrafenine The risk or severity of hypertension can be increased when Antrafenine is combined with Phenoxypropazine.
Aminophenazone The risk or severity of hypertension can be increased when Aminophenazone is combined with Phenoxypropazine.
Antipyrine The risk or severity of hypertension can be increased when Antipyrine is combined with Phenoxypropazine.
Tiaprofenic acid The risk or severity of hypertension can be increased when Tiaprofenic acid is combined with Phenoxypropazine.
Etoricoxib The risk or severity of hypertension can be increased when Etoricoxib is combined with Phenoxypropazine.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Phenoxypropazine.
Taxifolin The risk or severity of hypertension can be increased when Taxifolin is combined with Phenoxypropazine.
Oxyphenbutazone The risk or severity of hypertension can be increased when Oxyphenbutazone is combined with Phenoxypropazine.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Phenoxypropazine.
Benoxaprofen The risk or severity of hypertension can be increased when Benoxaprofen is combined with Phenoxypropazine.
Metamizole The risk or severity of hypertension can be increased when Metamizole is combined with Phenoxypropazine.
Zomepirac The risk or severity of hypertension can be increased when Zomepirac is combined with Phenoxypropazine.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Phenoxypropazine.
Cimicoxib The risk or severity of hypertension can be increased when Cimicoxib is combined with Phenoxypropazine.
Amibegron The risk or severity of hypertension can be increased when Amibegron is combined with Phenoxypropazine.
Nylidrin The risk or severity of hypertension can be increased when Nylidrin is combined with Phenoxypropazine.
Solabegron The risk or severity of hypertension can be increased when Solabegron is combined with Phenoxypropazine.
Lornoxicam The risk or severity of hypertension can be increased when Lornoxicam is combined with Phenoxypropazine.
Aceclofenac The risk or severity of hypertension can be increased when Aceclofenac is combined with Phenoxypropazine.
Zaltoprofen The risk or severity of hypertension can be increased when Zaltoprofen is combined with Phenoxypropazine.
Saralasin The risk or severity of hypertension can be increased when Saralasin is combined with Phenoxypropazine.
Azapropazone The risk or severity of hypertension can be increased when Azapropazone is combined with Phenoxypropazine.
Parecoxib The risk or severity of hypertension can be increased when Parecoxib is combined with Phenoxypropazine.
Salicylamide The risk or severity of hypertension can be increased when Salicylamide is combined with Phenoxypropazine.
Tyramine The risk or severity of hypertension can be increased when Tyramine is combined with Phenoxypropazine.
Mirabegron The risk or severity of hypertension can be increased when Mirabegron is combined with Phenoxypropazine.
Adrafinil The risk or severity of hypertension can be increased when Adrafinil is combined with Phenoxypropazine.
Kebuzone The risk or severity of hypertension can be increased when Kebuzone is combined with Phenoxypropazine.
Isoxicam The risk or severity of hypertension can be increased when Isoxicam is combined with Phenoxypropazine.
Indoprofen The risk or severity of hypertension can be increased when Indoprofen is combined with Phenoxypropazine.
Ibuproxam The risk or severity of hypertension can be increased when Ibuproxam is combined with Phenoxypropazine.
Floctafenine The risk or severity of hypertension can be increased when Floctafenine is combined with Phenoxypropazine.
Fenbufen The risk or severity of hypertension can be increased when Fenbufen is combined with Phenoxypropazine.
Etofenamate The risk or severity of hypertension can be increased when Etofenamate is combined with Phenoxypropazine.
Etilefrine The risk or severity of hypertension can be increased when Etilefrine is combined with Phenoxypropazine.
Epirizole The risk or severity of hypertension can be increased when Epirizole is combined with Phenoxypropazine.
Benzydamine The risk or severity of hypertension can be increased when Benzydamine is combined with Phenoxypropazine.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 13928824
    LEAHY MR, ROSE JT, PLOWMAN R: A preliminary study of phenoxypropazine in the treatment of depression. Am J Psychiatry. 1963 Apr;119:986-7.
  • PMID: 13956423
    IMLAH NW: Preliminary report on phenoxypropazine. Am J Psychiatry. 1963 May;119:1091-2.
  • PMID: 14069469
    ROSE JT, LEAHY MR, PLOWMAN R: A COMPARISON OF PHENOXYPROPAZINE AND AMYTRYPTILINE IN DEPRESSION. Am J Psychiatry. 1963 Oct;120:393-5.

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