Mebanazine

DB09248

small molecule withdrawn

Deskripsi

Mebanazine, also known as Actomol, is a monoamine oxidase inhibitor (MAOI) belonging to the hydrazine class of chemicals. It was used in the past as an antidepressant in the 1960s, but has since been discontinued because of its hepatotoxic potential.

Struktur Molekul 2D

Berat 136.198
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1322 Data
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Mebanazine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Mebanazine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Mebanazine.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Mebanazine.
Magnesium sulfate The therapeutic efficacy of Mebanazine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Mebanazine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Mebanazine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Mebanazine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Mebanazine.
Orphenadrine Mebanazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Mebanazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Mebanazine.
Pramipexole Mebanazine may increase the sedative activities of Pramipexole.
Ropinirole Mebanazine may increase the sedative activities of Ropinirole.
Rotigotine Mebanazine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Mebanazine.
Sodium oxybate Mebanazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Mebanazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Thalidomide Mebanazine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Mebanazine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Mebanazine.
Cyclosporine The risk or severity of hypertension can be increased when Cyclosporine is combined with Mebanazine.
Icosapent The risk or severity of hypertension can be increased when Icosapent is combined with Mebanazine.
Mesalazine The risk or severity of hypertension can be increased when Mesalazine is combined with Mebanazine.
Indomethacin The risk or severity of hypertension can be increased when Indomethacin is combined with Mebanazine.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Mebanazine.
Nabumetone The risk or severity of hypertension can be increased when Nabumetone is combined with Mebanazine.
Ketorolac The risk or severity of hypertension can be increased when Ketorolac is combined with Mebanazine.
Tenoxicam The risk or severity of hypertension can be increased when Tenoxicam is combined with Mebanazine.
Celecoxib The risk or severity of hypertension can be increased when Celecoxib is combined with Mebanazine.
Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Mebanazine.
Rofecoxib The risk or severity of hypertension can be increased when Rofecoxib is combined with Mebanazine.
Piroxicam The risk or severity of hypertension can be increased when Piroxicam is combined with Mebanazine.
Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Mebanazine.
Valdecoxib The risk or severity of hypertension can be increased when Valdecoxib is combined with Mebanazine.
Diclofenac The risk or severity of hypertension can be increased when Diclofenac is combined with Mebanazine.
Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Mebanazine.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Mebanazine.
Flurbiprofen The risk or severity of hypertension can be increased when Flurbiprofen is combined with Mebanazine.
Etodolac The risk or severity of hypertension can be increased when Etodolac is combined with Mebanazine.
Mefenamic acid The risk or severity of hypertension can be increased when Mefenamic acid is combined with Mebanazine.
Naproxen The risk or severity of hypertension can be increased when Naproxen is combined with Mebanazine.
Sulfasalazine The risk or severity of hypertension can be increased when Sulfasalazine is combined with Mebanazine.
Phenylbutazone The risk or severity of hypertension can be increased when Phenylbutazone is combined with Mebanazine.
Meloxicam The risk or severity of hypertension can be increased when Meloxicam is combined with Mebanazine.
Carprofen The risk or severity of hypertension can be increased when Carprofen is combined with Mebanazine.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Mebanazine.
Diflunisal The risk or severity of hypertension can be increased when Diflunisal is combined with Mebanazine.
Salicylic acid The risk or severity of hypertension can be increased when Salicylic acid is combined with Mebanazine.
Meclofenamic acid The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Mebanazine.
Dopamine The risk or severity of hypertension can be increased when Dopamine is combined with Mebanazine.
Oxaprozin The risk or severity of hypertension can be increased when Oxaprozin is combined with Mebanazine.
Ketoprofen The risk or severity of hypertension can be increased when Ketoprofen is combined with Mebanazine.
Balsalazide The risk or severity of hypertension can be increased when Balsalazide is combined with Mebanazine.
Ibuprofen The risk or severity of hypertension can be increased when Ibuprofen is combined with Mebanazine.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Mebanazine.
Propafenone The risk or severity of hypertension can be increased when Propafenone is combined with Mebanazine.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Mebanazine.
Lumiracoxib The risk or severity of hypertension can be increased when Lumiracoxib is combined with Mebanazine.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Mebanazine.
Magnesium salicylate The risk or severity of hypertension can be increased when Magnesium salicylate is combined with Mebanazine.
Salsalate The risk or severity of hypertension can be increased when Salsalate is combined with Mebanazine.
Choline magnesium trisalicylate The risk or severity of hypertension can be increased when Choline magnesium trisalicylate is combined with Mebanazine.
Antrafenine The risk or severity of hypertension can be increased when Antrafenine is combined with Mebanazine.
Aminophenazone The risk or severity of hypertension can be increased when Aminophenazone is combined with Mebanazine.
Antipyrine The risk or severity of hypertension can be increased when Antipyrine is combined with Mebanazine.
Tiaprofenic acid The risk or severity of hypertension can be increased when Tiaprofenic acid is combined with Mebanazine.
Etoricoxib The risk or severity of hypertension can be increased when Etoricoxib is combined with Mebanazine.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Mebanazine.
Taxifolin The risk or severity of hypertension can be increased when Taxifolin is combined with Mebanazine.
Oxyphenbutazone The risk or severity of hypertension can be increased when Oxyphenbutazone is combined with Mebanazine.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Mebanazine.
Benoxaprofen The risk or severity of hypertension can be increased when Benoxaprofen is combined with Mebanazine.
Metamizole The risk or severity of hypertension can be increased when Metamizole is combined with Mebanazine.
Zomepirac The risk or severity of hypertension can be increased when Zomepirac is combined with Mebanazine.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Mebanazine.
Cimicoxib The risk or severity of hypertension can be increased when Cimicoxib is combined with Mebanazine.
Amibegron The risk or severity of hypertension can be increased when Amibegron is combined with Mebanazine.
Nylidrin The risk or severity of hypertension can be increased when Nylidrin is combined with Mebanazine.
Solabegron The risk or severity of hypertension can be increased when Solabegron is combined with Mebanazine.
Lornoxicam The risk or severity of hypertension can be increased when Lornoxicam is combined with Mebanazine.
Aceclofenac The risk or severity of hypertension can be increased when Aceclofenac is combined with Mebanazine.
Zaltoprofen The risk or severity of hypertension can be increased when Zaltoprofen is combined with Mebanazine.
Saralasin The risk or severity of hypertension can be increased when Saralasin is combined with Mebanazine.
Azapropazone The risk or severity of hypertension can be increased when Azapropazone is combined with Mebanazine.
Parecoxib The risk or severity of hypertension can be increased when Parecoxib is combined with Mebanazine.
Salicylamide The risk or severity of hypertension can be increased when Salicylamide is combined with Mebanazine.
Tyramine The risk or severity of hypertension can be increased when Tyramine is combined with Mebanazine.
Mirabegron The risk or severity of hypertension can be increased when Mirabegron is combined with Mebanazine.
Adrafinil The risk or severity of hypertension can be increased when Adrafinil is combined with Mebanazine.
Kebuzone The risk or severity of hypertension can be increased when Kebuzone is combined with Mebanazine.
Isoxicam The risk or severity of hypertension can be increased when Isoxicam is combined with Mebanazine.
Indoprofen The risk or severity of hypertension can be increased when Indoprofen is combined with Mebanazine.
Ibuproxam The risk or severity of hypertension can be increased when Ibuproxam is combined with Mebanazine.
Floctafenine The risk or severity of hypertension can be increased when Floctafenine is combined with Mebanazine.
Fenbufen The risk or severity of hypertension can be increased when Fenbufen is combined with Mebanazine.
Etofenamate The risk or severity of hypertension can be increased when Etofenamate is combined with Mebanazine.
Etilefrine The risk or severity of hypertension can be increased when Etilefrine is combined with Mebanazine.
Epirizole The risk or severity of hypertension can be increased when Epirizole is combined with Mebanazine.
Benzydamine The risk or severity of hypertension can be increased when Benzydamine is combined with Mebanazine.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 5889715
    Gilmour SJ: Clinical trial of mebanazine--a new monoamine oxidase inhibitor. Br J Psychiatry. 1965 Sep;111(478):899-902.
  • PMID: 5320546
    Barker JC, Jan IA, Enoch MD: A controlled trial of mebanazine ('Actomol') in depression. Br J Psychiatry. 1965 Nov;111(480):1095-100.
  • PMID: 5327282
    Knott F: A preliminary trial of mebanazine in depressive states. J New Drugs. 1965 Nov-Dec;5(6):345-7.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Actomol

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