Iproclozide

DB09247

small molecule withdrawn

Deskripsi

Iproclozide is an irreversible and selective hydrazine class based monoamine oxidase inhibitor (MAOI). Although it was employed as an antidepressant for a time, the fact that the agent is capable of causing fulminant hepatitis and that its use has been documented as the cause for at least three reported fatalities has resulted ultimately in the agent being discontinued.

Struktur Molekul 2D

Berat 242.7
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

676 Data
Buprenorphine Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Iproclozide.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Iproclozide.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Iproclozide.
Hydrocodone Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Iproclozide.
Magnesium sulfate The therapeutic efficacy of Iproclozide can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Iproclozide may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Iproclozide.
Mirtazapine Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Iproclozide.
Orphenadrine Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Iproclozide.
Pramipexole Iproclozide may increase the sedative activities of Pramipexole.
Ropinirole Iproclozide may increase the sedative activities of Ropinirole.
Rotigotine Iproclozide may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Iproclozide.
Sodium oxybate Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Iproclozide.
Thalidomide Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Iproclozide.
Dicoumarol The risk or severity of adverse effects can be increased when Iproclozide is combined with Dicoumarol.
Phenindione The risk or severity of adverse effects can be increased when Iproclozide is combined with Phenindione.
Warfarin The risk or severity of adverse effects can be increased when Iproclozide is combined with Warfarin.
Phenprocoumon The risk or severity of adverse effects can be increased when Iproclozide is combined with Phenprocoumon.
Acenocoumarol The risk or severity of adverse effects can be increased when Iproclozide is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of adverse effects can be increased when Iproclozide is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of adverse effects can be increased when Iproclozide is combined with Coumarin.
(R)-warfarin The risk or severity of adverse effects can be increased when Iproclozide is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of adverse effects can be increased when Iproclozide is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of adverse effects can be increased when Iproclozide is combined with Fluindione.
Clorindione The risk or severity of adverse effects can be increased when Iproclozide is combined with Clorindione.
Diphenadione The risk or severity of adverse effects can be increased when Iproclozide is combined with Diphenadione.
Tioclomarol The risk or severity of adverse effects can be increased when Iproclozide is combined with Tioclomarol.
(S)-Warfarin The risk or severity of adverse effects can be increased when Iproclozide is combined with (S)-Warfarin.
Ethanol Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Iproclozide.
Fluvoxamine The risk or severity of adverse effects can be increased when Iproclozide is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Iproclozide is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Iproclozide is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Iproclozide is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Iproclozide is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Iproclozide is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Iproclozide is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Iproclozide is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Iproclozide is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Iproclozide is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Iproclozide is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Iproclozide is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Iproclozide is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Iproclozide is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Iproclozide is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Iproclozide is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Iproclozide is combined with Alaproclate.
Zopiclone The risk or severity of adverse effects can be increased when Iproclozide is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Iproclozide.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Iproclozide.
Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Iproclozide.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Iproclozide.
Lorazepam The risk or severity of CNS depression can be increased when Lorazepam is combined with Iproclozide.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Iproclozide.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Iproclozide.
Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Iproclozide.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Iproclozide.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Iproclozide.
Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Iproclozide.
Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Iproclozide.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Iproclozide.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Iproclozide.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Iproclozide.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Iproclozide.
Phenytoin The risk or severity of CNS depression can be increased when Phenytoin is combined with Iproclozide.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Iproclozide.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Iproclozide.
Venlafaxine The risk or severity of CNS depression can be increased when Venlafaxine is combined with Iproclozide.
Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Iproclozide.
Morphine The risk or severity of CNS depression can be increased when Morphine is combined with Iproclozide.
Talbutal The risk or severity of CNS depression can be increased when Talbutal is combined with Iproclozide.
Pentobarbital The risk or severity of CNS depression can be increased when Pentobarbital is combined with Iproclozide.
Valproic acid The risk or severity of CNS depression can be increased when Valproic acid is combined with Iproclozide.
Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Iproclozide.
Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Iproclozide.
Dihydroergotamine The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Iproclozide.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Iproclozide.
Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Iproclozide.
Hydromorphone The risk or severity of CNS depression can be increased when Hydromorphone is combined with Iproclozide.
Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Iproclozide.
Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Iproclozide.
Protriptyline The risk or severity of CNS depression can be increased when Protriptyline is combined with Iproclozide.
Trimethadione The risk or severity of CNS depression can be increased when Trimethadione is combined with Iproclozide.
Clobazam The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Iproclozide.
Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Iproclozide.
Clozapine The risk or severity of CNS depression can be increased when Clozapine is combined with Iproclozide.
Meprobamate The risk or severity of CNS depression can be increased when Meprobamate is combined with Iproclozide.
Thiethylperazine The risk or severity of CNS depression can be increased when Thiethylperazine is combined with Iproclozide.

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