Peringatan Keamanan

In rare cases, toloxatone toxicity may cause fulminant hepatitis L1389.
More common adverse effects include dysuria, nausea, constipation, vertigo, and insomnia.
Administration of toloxatone can lead to an increased risk of serotonin syndrome with selective serotonin reuptake inhibitors (SSRI), and tricyclic antidepressants L1389. Increased blood pressure can occur with sympathomimetic medication coadministration. One study showed that when combined with meals, elevated doses of toloxatone may contribute to elevated blood pressure in healthy subjects. This pharmacodynamic interaction could be explained by enhanced tyramine bioavailability in the presence of toloxatone. This tyramine in meals and toloxatone is unlikely to occur in patients after long-term administration of the drug at therapeutic dosages A31955.

Toloxatone

DB09245

small molecule experimental

Deskripsi

Toloxatone is an antidepressant agent, the first ever use of which was in France, 1984. It acts as a selective and reversible inhibitor of monoamine oxidase-A (MOA) L1388.

Struktur Molekul 2D

Berat 207.229
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1-3 h [A31957]
Volume Distribusi -
Klirens (Clearance) High hepatic excretion rate [A31957]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Mainly hepatic 1% of drug is excreted unchanged in the urine A31957

Interaksi Obat

1730 Data
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Toloxatone.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Toloxatone.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Toloxatone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Toloxatone.
Magnesium sulfate The therapeutic efficacy of Toloxatone can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Toloxatone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Toloxatone may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Toloxatone.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Toloxatone.
Orphenadrine Toloxatone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Toloxatone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Toloxatone.
Pramipexole Toloxatone may increase the sedative activities of Pramipexole.
Ropinirole Toloxatone may increase the sedative activities of Ropinirole.
Rotigotine Toloxatone may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Toloxatone.
Sodium oxybate Toloxatone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Toloxatone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Thalidomide Toloxatone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Toloxatone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Toloxatone.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Toloxatone.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Toloxatone.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Toloxatone.
Propafenone The risk or severity of hypertension can be increased when Propafenone is combined with Toloxatone.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Toloxatone.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Toloxatone.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Toloxatone.
Taxifolin The risk or severity of hypertension can be increased when Taxifolin is combined with Toloxatone.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Toloxatone.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Toloxatone.
Amibegron The risk or severity of hypertension can be increased when Amibegron is combined with Toloxatone.
Nylidrin The risk or severity of hypertension can be increased when Nylidrin is combined with Toloxatone.
Solabegron The risk or severity of hypertension can be increased when Solabegron is combined with Toloxatone.
Saralasin The risk or severity of hypertension can be increased when Saralasin is combined with Toloxatone.
Tyramine The risk or severity of hypertension can be increased when Tyramine is combined with Toloxatone.
Adrafinil The risk or severity of hypertension can be increased when Adrafinil is combined with Toloxatone.
Etilefrine The risk or severity of hypertension can be increased when Etilefrine is combined with Toloxatone.
Synephrine The risk or severity of hypertension can be increased when Synephrine is combined with Toloxatone.
Dihydroergocornine The risk or severity of hypertension can be increased when Toloxatone is combined with Dihydroergocornine.
Amitraz The risk or severity of hypertension can be increased when Toloxatone is combined with Amitraz.
Atipamezole The risk or severity of hypertension can be increased when Toloxatone is combined with Atipamezole.
Ractopamine The risk or severity of hypertension can be increased when Toloxatone is combined with Ractopamine.
Anisodamine The risk or severity of hypertension can be increased when Toloxatone is combined with Anisodamine.
Tulobuterol The risk or severity of hypertension can be increased when Toloxatone is combined with Tulobuterol.
Dopexamine The risk or severity of hypertension can be increased when Toloxatone is combined with Dopexamine.
Siponimod The risk or severity of hypertension can be increased when Toloxatone is combined with Siponimod.
Idazoxan The risk or severity of hypertension can be increased when Toloxatone is combined with Idazoxan.
Ebselen The risk or severity of hypertension can be increased when Toloxatone is combined with Ebselen.
Higenamine The risk or severity of hypertension can be increased when Toloxatone is combined with Higenamine.
Reproterol The risk or severity of hypertension can be increased when Toloxatone is combined with Reproterol.
Theodrenaline The risk or severity of hypertension can be increased when Toloxatone is combined with Theodrenaline.
Tramazoline The risk or severity of hypertension can be increased when Toloxatone is combined with Tramazoline.
Octopamine The risk or severity of hypertension can be increased when Toloxatone is combined with Octopamine.
Fenozolone The risk or severity of hypertension can be increased when Toloxatone is combined with Fenozolone.
Dihydroergocristine The risk or severity of hypertension can be increased when Toloxatone is combined with Dihydroergocristine.
Norfenefrine The risk or severity of hypertension can be increased when Toloxatone is combined with Norfenefrine.
Dihydroergocryptine The risk or severity of hypertension can be increased when Toloxatone is combined with Dihydroergocryptine.
Oxyfedrine The risk or severity of hypertension can be increased when Toloxatone is combined with Oxyfedrine.
Terguride The risk or severity of hypertension can be increased when Toloxatone is combined with Terguride.
Xenon The risk or severity of adverse effects can be increased when Xenon is combined with Toloxatone.
Rimiterol The risk or severity of hypertension can be increased when Toloxatone is combined with Rimiterol.
Tretoquinol The risk or severity of hypertension can be increased when Toloxatone is combined with Tretoquinol.
Prenalterol The risk or severity of hypertension can be increased when Toloxatone is combined with Prenalterol.
Xamoterol The risk or severity of hypertension can be increased when Toloxatone is combined with Xamoterol.
Mefenorex The risk or severity of hypertension can be increased when Toloxatone is combined with Mefenorex.
Deoxyepinephrine The risk or severity of hypertension can be increased when Toloxatone is combined with Deoxyepinephrine.
Quinoline Yellow WS The risk or severity of hypertension can be increased when Toloxatone is combined with Quinoline Yellow WS.
Selpercatinib The risk or severity of hypertension can be increased when Toloxatone is combined with Selpercatinib.
Naxitamab The risk or severity of hypertension can be increased when Toloxatone is combined with Naxitamab.
Apraclonidine Toloxatone may increase the alpha-adrenergic activities of Apraclonidine.
Atomoxetine The risk or severity of adverse effects can be increased when Toloxatone is combined with Atomoxetine.
Betahistine The metabolism of Betahistine can be decreased when combined with Toloxatone.
Bezafibrate Toloxatone may increase the hepatotoxic activities of Bezafibrate.
Buprenorphine Toloxatone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Bupropion The risk or severity of adverse effects can be increased when Toloxatone is combined with Bupropion.
Buspirone The risk or severity of hypertension can be increased when Toloxatone is combined with Buspirone.
Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Toloxatone.
Cyclobenzaprine Cyclobenzaprine may increase the serotonergic activities of Toloxatone.
Cyproheptadine Toloxatone may increase the anticholinergic activities of Cyproheptadine.
Dextromethorphan The risk or severity of serotonin syndrome can be increased when Toloxatone is combined with Dextromethorphan.
Diethylpropion The risk or severity of adverse effects can be increased when Toloxatone is combined with Diethylpropion.
Domperidone The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Toloxatone is combined with Domperidone.
Hydrocodone Toloxatone may increase the serotonergic and central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydromorphone Toloxatone may increase the serotonergic activities of Hydromorphone.
Isometheptene Toloxatone may increase the sympathomimetic activities of Isometheptene.
Levonordefrin Toloxatone may increase the hypertensive activities of Levonordefrin.
Lithium hydroxide The risk or severity of serotonin syndrome can be increased when Toloxatone is combined with Lithium hydroxide.
Lithium citrate The risk or severity of serotonin syndrome can be increased when Toloxatone is combined with Lithium citrate.
Setiptiline The risk or severity of adverse effects can be increased when Toloxatone is combined with Setiptiline.
Aptazapine The risk or severity of adverse effects can be increased when Toloxatone is combined with Aptazapine.
Maprotiline The risk or severity of adverse effects can be increased when Toloxatone is combined with Maprotiline.
Mianserin The risk or severity of adverse effects can be increased when Toloxatone is combined with Mianserin.
Esmirtazapine The risk or severity of adverse effects can be increased when Toloxatone is combined with Esmirtazapine.
Mequitazine Toloxatone may increase the anticholinergic activities of Mequitazine.
Methadone The risk or severity of serotonin syndrome can be increased when Toloxatone is combined with Methadone.
Methyldopa Toloxatone may decrease the hypotensive activities of Methyldopa.
Methylphenidate Toloxatone may increase the hypertensive activities of Methylphenidate.
Dexmethylphenidate Toloxatone may increase the hypertensive activities of Dexmethylphenidate.
Oxycodone Toloxatone may increase the serotonergic and central nervous system depressant (CNS depressant) activities of Oxycodone.

Target Protein

Amine oxidase [flavin-containing] B MAOB
Amine oxidase [flavin-containing] A MAOA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 1705137
    Berlin I, Zimmer R, Thiede HM, Payan C, Hergueta T, Robin L, Puech AJ: Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects. Br J Clin Pharmacol. 1990 Dec;30(6):805-16.
  • PMID: 1424410
    Provost JC, Funck-Brentano C, Rovei V, D'Estanque J, Ego D, Jaillon P: Pharmacokinetic and pharmacodynamic interaction between toloxatone, a new reversible monoamine oxidase-A inhibitor, and oral tyramine in healthy subjects. Clin Pharmacol Ther. 1992 Oct;52(4):384-93.
  • PMID: 2685852
    Schoerlin MP, Guentert TW: Pharmacokinetics and metabolism of reversible MAO-A inhibitors in the human. Psychiatr Prax. 1989 Aug;16 Suppl 1:11-7.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Humoryl — Sanofi Aventis

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul