The most common adverse events reported in clinical trials were ankle oedema (6%), headache (3.8%), palpitation (2.7%), flushing (2.2%), dizziness (1.6%), rash (0.5%) and fatigue (0.5%) A7845.
Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Lomitapide | The metabolism of Lomitapide can be decreased when combined with Manidipine. |
| Ceritinib | Manidipine may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Manidipine may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Manidipine. |
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Manidipine. |
| Amifostine | Manidipine may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Manidipine. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Manidipine. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Manidipine. |
| Obinutuzumab | Manidipine may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Manidipine. |
| Rituximab | Manidipine may increase the hypotensive activities of Rituximab. |
| Desmopressin | Desmopressin may decrease the antihypertensive activities of Manidipine. |
| Isoetharine | Isoetharine may decrease the antihypertensive activities of Manidipine. |
| Etomidate | Etomidate may decrease the antihypertensive activities of Manidipine. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Manidipine. |
| Norepinephrine | Norepinephrine may decrease the antihypertensive activities of Manidipine. |
| Phenylpropanolamine | Phenylpropanolamine may decrease the antihypertensive activities of Manidipine. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Manidipine. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Manidipine. |
| Sumatriptan | Sumatriptan may decrease the antihypertensive activities of Manidipine. |
| Methoxamine | Methoxamine may decrease the antihypertensive activities of Manidipine. |
| Orciprenaline | Orciprenaline may decrease the antihypertensive activities of Manidipine. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Manidipine. |
| Dobutamine | Dobutamine may decrease the antihypertensive activities of Manidipine. |
| Pseudoephedrine | Pseudoephedrine may decrease the antihypertensive activities of Manidipine. |
| Ritodrine | Ritodrine may decrease the antihypertensive activities of Manidipine. |
| Terbutaline | Terbutaline may decrease the antihypertensive activities of Manidipine. |
| Bitolterol | Bitolterol may decrease the antihypertensive activities of Manidipine. |
| Diethylpropion | Diethylpropion may decrease the antihypertensive activities of Manidipine. |
| Naratriptan | Naratriptan may decrease the antihypertensive activities of Manidipine. |
| Rizatriptan | Rizatriptan may decrease the antihypertensive activities of Manidipine. |
| Dopamine | Dopamine may decrease the antihypertensive activities of Manidipine. |
| Frovatriptan | Frovatriptan may decrease the antihypertensive activities of Manidipine. |
| Isoprenaline | Isoprenaline may decrease the antihypertensive activities of Manidipine. |
| Arbutamine | Arbutamine may decrease the antihypertensive activities of Manidipine. |
| Fenoterol | Fenoterol may decrease the antihypertensive activities of Manidipine. |
| Pirbuterol | Pirbuterol may decrease the antihypertensive activities of Manidipine. |
| Ephedra sinica root | Ephedra sinica root may decrease the antihypertensive activities of Manidipine. |
| Ephedrine | Ephedrine may decrease the antihypertensive activities of Manidipine. |
| Mephentermine | Mephentermine may decrease the antihypertensive activities of Manidipine. |
| Procaterol | Procaterol may decrease the antihypertensive activities of Manidipine. |
| Clenbuterol | Clenbuterol may decrease the antihypertensive activities of Manidipine. |
| Bambuterol | Bambuterol may decrease the antihypertensive activities of Manidipine. |
| MMDA | MMDA may decrease the antihypertensive activities of Manidipine. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Manidipine. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Manidipine. |
| Tenamfetamine | Tenamfetamine may decrease the antihypertensive activities of Manidipine. |
| Chlorphentermine | Chlorphentermine may decrease the antihypertensive activities of Manidipine. |
| Phendimetrazine | Phendimetrazine may decrease the antihypertensive activities of Manidipine. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Manidipine. |
| 1-benzylimidazole | 1-benzylimidazole may decrease the antihypertensive activities of Manidipine. |
| Amineptine | Amineptine may decrease the antihypertensive activities of Manidipine. |
| Amibegron | Amibegron may decrease the antihypertensive activities of Manidipine. |
| Naluzotan | Naluzotan may decrease the antihypertensive activities of Manidipine. |
| Solabegron | Solabegron may decrease the antihypertensive activities of Manidipine. |
| Droxidopa | Droxidopa may decrease the antihypertensive activities of Manidipine. |
| Nitrous oxide | Nitrous oxide may decrease the antihypertensive activities of Manidipine. |
| Isometheptene | Isometheptene may decrease the antihypertensive activities of Manidipine. |
| Levonordefrin | Levonordefrin may decrease the antihypertensive activities of Manidipine. |
| Naphazoline | Naphazoline may decrease the antihypertensive activities of Manidipine. |
| Tetryzoline | Tetryzoline may decrease the antihypertensive activities of Manidipine. |
| Cinitapride | Cinitapride may decrease the antihypertensive activities of Manidipine. |
| Tyramine | Tyramine may decrease the antihypertensive activities of Manidipine. |
| Adrafinil | Adrafinil may decrease the antihypertensive activities of Manidipine. |
| Ifenprodil | Ifenprodil may decrease the antihypertensive activities of Manidipine. |
| Hexoprenaline | Hexoprenaline may decrease the antihypertensive activities of Manidipine. |
| Etilefrine | Etilefrine may decrease the antihypertensive activities of Manidipine. |
| Dimetacrine | Dimetacrine may decrease the antihypertensive activities of Manidipine. |
| Butriptyline | Butriptyline may decrease the antihypertensive activities of Manidipine. |
| Cirazoline | Cirazoline may decrease the antihypertensive activities of Manidipine. |
| Synephrine | Synephrine may decrease the antihypertensive activities of Manidipine. |
| Moxisylyte | Moxisylyte may decrease the antihypertensive activities of Manidipine. |
| Oxaprotiline | Oxaprotiline may decrease the antihypertensive activities of Manidipine. |
| Iofetamine I-123 | Iofetamine I-123 may decrease the antihypertensive activities of Manidipine. |
| Racepinephrine | Racepinephrine may decrease the antihypertensive activities of Manidipine. |
| DL-Methylephedrine | DL-Methylephedrine may decrease the antihypertensive activities of Manidipine. |
| Amitraz | Amitraz may decrease the antihypertensive activities of Manidipine. |
| Medetomidine | Medetomidine may decrease the antihypertensive activities of Manidipine. |
| Xylazine | Xylazine may decrease the antihypertensive activities of Manidipine. |
| Atipamezole | Atipamezole may decrease the antihypertensive activities of Manidipine. |
| Ractopamine | Ractopamine may decrease the antihypertensive activities of Manidipine. |
| Romifidine | Romifidine may decrease the antihypertensive activities of Manidipine. |
| Detomidine | Detomidine may decrease the antihypertensive activities of Manidipine. |
| Etafedrine | Etafedrine may decrease the antihypertensive activities of Manidipine. |
| Tetrahydrocannabivarin | Tetrahydrocannabivarin may decrease the antihypertensive activities of Manidipine. |
| PF-00610355 | PF-00610355 may decrease the antihypertensive activities of Manidipine. |
| Ritobegron | Ritobegron may decrease the antihypertensive activities of Manidipine. |
| Abediterol | Abediterol may decrease the antihypertensive activities of Manidipine. |
| Tulobuterol | Tulobuterol may decrease the antihypertensive activities of Manidipine. |
| Dopexamine | Dopexamine may decrease the antihypertensive activities of Manidipine. |
| Piclozotan | Piclozotan may decrease the antihypertensive activities of Manidipine. |
| Idazoxan | Idazoxan may decrease the antihypertensive activities of Manidipine. |
| Higenamine | Higenamine may decrease the antihypertensive activities of Manidipine. |
| Reproterol | Reproterol may decrease the antihypertensive activities of Manidipine. |
| Theodrenaline | Theodrenaline may decrease the antihypertensive activities of Manidipine. |
| Tramazoline | Tramazoline may decrease the antihypertensive activities of Manidipine. |
| Mephedrone | Mephedrone may decrease the antihypertensive activities of Manidipine. |
| Amitriptylinoxide | Amitriptylinoxide may decrease the antihypertensive activities of Manidipine. |
| Dibenzepin | Dibenzepin may decrease the antihypertensive activities of Manidipine. |