As with any calcium channel blocker toxicity, bradycardia and hypotension may result from overdose. The treatment of patients with bradycardia and hypotension begins with supportive therapy and atropine, however, patients with severe toxicity do not have an adequate response and must be managed more aggressively.
Calcium plays an imperative role in myocardial contractility, automaticity and vascular tone. Administration of exogenous calcium is of benefit in cases of toxicity L1384.
Azelnidipine is a dihydropyridine calcium channel blocker. It is marketed by Daiichi-Sankyo pharmaceuticals, Inc. in Japan. It has a gradual onset of action and produces a long-lasting decrease in blood pressure, with only a small increase in heart rate, unlike some other calcium channel blockers L1379. It is currently being studied for post-ischemic stroke management L1380.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ceritinib | Azelnidipine may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Azelnidipine may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Azelnidipine. |
| Cimetidine | The serum concentration of Azelnidipine can be increased when it is combined with Cimetidine. |
| Clopidogrel | The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Azelnidipine. |
| Efavirenz | The serum concentration of Azelnidipine can be decreased when it is combined with Efavirenz. |
| Melatonin | The therapeutic efficacy of Azelnidipine can be decreased when used in combination with Melatonin. |
| Nafcillin | The therapeutic efficacy of Azelnidipine can be decreased when used in combination with Nafcillin. |
| Nitroprusside | Azelnidipine may increase the hypotensive activities of Nitroprusside. |
| Dantrolene | The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Azelnidipine. |
| Lithium citrate | The risk or severity of adverse effects can be increased when Azelnidipine is combined with Lithium citrate. |
| Lithium carbonate | The risk or severity of adverse effects can be increased when Azelnidipine is combined with Lithium carbonate. |
| Lithium hydroxide | The risk or severity of adverse effects can be increased when Azelnidipine is combined with Lithium hydroxide. |
| Boceprevir | The serum concentration of Azelnidipine can be increased when it is combined with Boceprevir. |
| Ibutilide | Ibutilide may increase the arrhythmogenic activities of Azelnidipine. |
| Hyoscyamine | Hyoscyamine may increase the arrhythmogenic activities of Azelnidipine. |
| Atropine | Atropine may increase the arrhythmogenic activities of Azelnidipine. |
| Adenosine | Adenosine may increase the arrhythmogenic activities of Azelnidipine. |
| Moricizine | Moricizine may increase the arrhythmogenic activities of Azelnidipine. |
| Levosimendan | Levosimendan may increase the arrhythmogenic activities of Azelnidipine. |
| Procainamide | Procainamide may increase the arrhythmogenic activities of Azelnidipine. |
| Tocainide | Tocainide may increase the arrhythmogenic activities of Azelnidipine. |
| Flecainide | Flecainide may increase the arrhythmogenic activities of Azelnidipine. |
| Encainide | Encainide may increase the arrhythmogenic activities of Azelnidipine. |
| Ajmaline | Ajmaline may increase the arrhythmogenic activities of Azelnidipine. |
| Aprindine | Aprindine may increase the arrhythmogenic activities of Azelnidipine. |
| Azimilide | Azimilide may increase the arrhythmogenic activities of Azelnidipine. |
| Tedisamil | Tedisamil may increase the arrhythmogenic activities of Azelnidipine. |
| Vernakalant | Vernakalant may increase the arrhythmogenic activities of Azelnidipine. |
| Cariporide | Cariporide may increase the arrhythmogenic activities of Azelnidipine. |
| Xylometazoline | Xylometazoline may increase the arrhythmogenic activities of Azelnidipine. |
| Sparteine | Sparteine may increase the arrhythmogenic activities of Azelnidipine. |
| Fasudil | Fasudil may increase the arrhythmogenic activities of Azelnidipine. |
| Melperone | Melperone may increase the arrhythmogenic activities of Azelnidipine. |
| Carteolol | Azelnidipine may increase the arrhythmogenic activities of Carteolol. |
| Metipranolol | Azelnidipine may increase the arrhythmogenic activities of Metipranolol. |
| Tropisetron | Azelnidipine may increase the arrhythmogenic activities of Tropisetron. |
| Simendan | Azelnidipine may increase the arrhythmogenic activities of Simendan. |
| Spiradoline | Azelnidipine may increase the arrhythmogenic activities of Spiradoline. |
| Pilsicainide | Azelnidipine may increase the arrhythmogenic activities of Pilsicainide. |
| Cicletanine | Azelnidipine may increase the arrhythmogenic activities of Cicletanine. |
| Cibenzoline | Azelnidipine may increase the arrhythmogenic activities of Cibenzoline. |
| Nizofenone | Azelnidipine may increase the arrhythmogenic activities of Nizofenone. |
| Prajmaline | Azelnidipine may increase the arrhythmogenic activities of Prajmaline. |
| Tiracizine | Azelnidipine may increase the arrhythmogenic activities of Tiracizine. |
| Ethacizine | Azelnidipine may increase the arrhythmogenic activities of Ethacizine. |
| Lorajmine | Azelnidipine may increase the arrhythmogenic activities of Lorajmine. |
| Bunaftine | Azelnidipine may increase the arrhythmogenic activities of Bunaftine. |
| Lorcainide | Azelnidipine may increase the arrhythmogenic activities of Lorcainide. |
| Hydroquinine | Azelnidipine may increase the arrhythmogenic activities of Hydroquinine. |
| Bioallethrin | Azelnidipine may increase the arrhythmogenic activities of Bioallethrin. |
| Fosfructose | Azelnidipine may increase the arrhythmogenic activities of Fosfructose. |
| Hydroquinidine | Azelnidipine may increase the arrhythmogenic activities of Hydroquinidine. |
| SOR-C13 | Azelnidipine may increase the arrhythmogenic activities of SOR-C13. |
| Digoxin | Digoxin may increase the arrhythmogenic activities of Azelnidipine. |
| Acetyldigitoxin | Acetyldigitoxin may increase the arrhythmogenic activities of Azelnidipine. |
| Deslanoside | Deslanoside may increase the arrhythmogenic activities of Azelnidipine. |
| Cymarin | Azelnidipine may increase the arrhythmogenic activities of Cymarin. |
| Metildigoxin | Azelnidipine may increase the arrhythmogenic activities of Metildigoxin. |
| Acetyldigoxin | Azelnidipine may increase the arrhythmogenic activities of Acetyldigoxin. |
| Niguldipine | Azelnidipine may increase the arrhythmogenic activities of Niguldipine. |
| Bretylium | Bretylium may increase the arrhythmogenic activities of Azelnidipine. |
| Isradipine | Isradipine may increase the arrhythmogenic activities of Azelnidipine. |
| Diltiazem | Diltiazem may increase the arrhythmogenic activities of Azelnidipine. |
| Trimethadione | Trimethadione may increase the arrhythmogenic activities of Azelnidipine. |
| Amlodipine | Amlodipine may increase the arrhythmogenic activities of Azelnidipine. |
| Nimodipine | Nimodipine may increase the arrhythmogenic activities of Azelnidipine. |
| Lercanidipine | Lercanidipine may increase the arrhythmogenic activities of Azelnidipine. |
| Lamotrigine | Lamotrigine may increase the arrhythmogenic activities of Azelnidipine. |
| Cinnarizine | Cinnarizine may increase the arrhythmogenic activities of Azelnidipine. |
| Nicardipine | Nicardipine may increase the arrhythmogenic activities of Azelnidipine. |
| Verapamil | Verapamil may increase the arrhythmogenic activities of Azelnidipine. |
| Losartan | Losartan may increase the arrhythmogenic activities of Azelnidipine. |
| Levomenthol | Levomenthol may increase the arrhythmogenic activities of Azelnidipine. |
| Zonisamide | Zonisamide may increase the arrhythmogenic activities of Azelnidipine. |
| Nitrendipine | Nitrendipine may increase the arrhythmogenic activities of Azelnidipine. |
| Perhexiline | Perhexiline may increase the arrhythmogenic activities of Azelnidipine. |
| Bepridil | Bepridil may increase the arrhythmogenic activities of Azelnidipine. |
| Nimesulide | Nimesulide may increase the arrhythmogenic activities of Azelnidipine. |
| Prenylamine | Prenylamine may increase the arrhythmogenic activities of Azelnidipine. |
| Cyclandelate | Cyclandelate may increase the arrhythmogenic activities of Azelnidipine. |
| Flunarizine | Flunarizine may increase the arrhythmogenic activities of Azelnidipine. |
| Fluspirilene | Fluspirilene may increase the arrhythmogenic activities of Azelnidipine. |
| Clevidipine | Clevidipine may increase the arrhythmogenic activities of Azelnidipine. |
| Methsuximide | Methsuximide may increase the arrhythmogenic activities of Azelnidipine. |
| Seletracetam | Seletracetam may increase the arrhythmogenic activities of Azelnidipine. |
| Nylidrin | Nylidrin may increase the arrhythmogenic activities of Azelnidipine. |
| Ziconotide | Ziconotide may increase the arrhythmogenic activities of Azelnidipine. |
| Dotarizine | Dotarizine may increase the arrhythmogenic activities of Azelnidipine. |
| Nilvadipine | Nilvadipine may increase the arrhythmogenic activities of Azelnidipine. |
| Tranilast | Tranilast may increase the arrhythmogenic activities of Azelnidipine. |
| Agmatine | Agmatine may increase the arrhythmogenic activities of Azelnidipine. |
| Fendiline | Fendiline may increase the arrhythmogenic activities of Azelnidipine. |
| Eperisone | Eperisone may increase the arrhythmogenic activities of Azelnidipine. |
| Trimebutine | Trimebutine may increase the arrhythmogenic activities of Azelnidipine. |
| Pinaverium | Pinaverium may increase the arrhythmogenic activities of Azelnidipine. |
| Nicorandil | Nicorandil may increase the arrhythmogenic activities of Azelnidipine. |
| Barnidipine | Barnidipine may increase the arrhythmogenic activities of Azelnidipine. |
| Aranidipine | Aranidipine may increase the arrhythmogenic activities of Azelnidipine. |
| Benidipine | Azelnidipine may increase the arrhythmogenic activities of Benidipine. |