Peringatan Keamanan

Exposure to Droxicam is associated with significantly increased risk of hepatic toxicity resulting in its withdrawal from the market A31529.

Droxicam

DB09215

small molecule withdrawn

Deskripsi

Droxicam is an oxicam non-steroidal anti-inflammatory drug and a prodrug of DB00554. It is used to reduce pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.

Struktur Molekul 2D

Berat 357.34
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Data not available for prodrug. See [DB00554] for information on the active compound.
Volume Distribusi Data not available for prodrug. See [DB00554] for information on the active compound.
Klirens (Clearance) Data not available for prodrug. See [DB00554] for information on the active compound.

Absorpsi

Tmax of 7 h. Bioavailability equivalent to DB00554 which is thought to be completely absorbed in humans based on data from rabbits A7026.

Metabolisme

Converted to DB00554 via ester hydrolysis A7026.

Rute Eliminasi

Data not available for prodrug. See DB00554 for information on the active compound.

Interaksi Obat

1393 Data
Amlodipine Droxicam may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Droxicam.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Droxicam.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Droxicam.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Droxicam.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Droxicam.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Droxicam.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Droxicam.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Droxicam.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Droxicam.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Droxicam.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Droxicam.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Droxicam.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Droxicam.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Droxicam.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Droxicam.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Droxicam.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Droxicam.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Droxicam.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Droxicam.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Droxicam.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Droxicam.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Droxicam.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Droxicam.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Droxicam.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Droxicam.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Droxicam.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Droxicam.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Droxicam.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Droxicam.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Droxicam.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Droxicam.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Droxicam.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Droxicam.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Droxicam.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Droxicam.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Droxicam.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Droxicam.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Droxicam.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Droxicam.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Droxicam.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Droxicam.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Droxicam.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Droxicam.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Droxicam.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Droxicam.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Droxicam.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Droxicam.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Droxicam.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Droxicam.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Droxicam.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Droxicam.
Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Droxicam.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Droxicam.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Droxicam.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Droxicam.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Droxicam.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Droxicam.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Droxicam.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Droxicam.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Droxicam.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Droxicam.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Droxicam.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Droxicam.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Droxicam.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Droxicam.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Droxicam.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Droxicam.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Droxicam.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Droxicam.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Droxicam.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Droxicam.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Droxicam.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Droxicam.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Droxicam.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Droxicam.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Droxicam.
MMDA The risk or severity of hypertension can be increased when MMDA is combined with Droxicam.
Midomafetamine The risk or severity of hypertension can be increased when Midomafetamine is combined with Droxicam.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Droxicam.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Droxicam.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Droxicam.
Tenamfetamine The risk or severity of hypertension can be increased when Tenamfetamine is combined with Droxicam.
Chlorphentermine The risk or severity of hypertension can be increased when Chlorphentermine is combined with Droxicam.
Dextroamphetamine The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Droxicam.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Droxicam.
Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Droxicam.
Periciazine The risk or severity of hypertension can be increased when Periciazine is combined with Droxicam.
Acepromazine The risk or severity of hypertension can be increased when Acepromazine is combined with Droxicam.
Thioproperazine The risk or severity of hypertension can be increased when Thioproperazine is combined with Droxicam.
Zuclopenthixol The risk or severity of hypertension can be increased when Zuclopenthixol is combined with Droxicam.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Droxicam.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Droxicam.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Droxicam.
Iproniazid The risk or severity of hypertension can be increased when Iproniazid is combined with Droxicam.
Nialamide The risk or severity of hypertension can be increased when Nialamide is combined with Droxicam.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Lysergic acid diethylamide is combined with Droxicam.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Droxicam.
Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Droxicam.
Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Droxicam.

Target Protein

Prostaglandin G/H synthase 1 PTGS1
Prostaglandin G/H synthase 2 PTGS2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 3278945
    Esteve J, Farre AJ, Roser R: Pharmacological profile of droxicam. Gen Pharmacol. 1988;19(1):49-54.
  • PMID: 8162655
    Olkkola KT, Brunetto AV, Mattila MJ: Pharmacokinetics of oxicam nonsteroidal anti-inflammatory agents. Clin Pharmacokinet. 1994 Feb;26(2):107-20.
  • PMID: 16867024
    Lapeyre-Mestre M, de Castro AM, Bareille MP, Del Pozo JG, Requejo AA, Arias LM, Montastruc JL, Carvajal A: Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems. Fundam Clin Pharmacol. 2006 Aug;20(4):391-5. doi: 10.1111/j.1472-8206.2006.00416.x.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul