Peringatan Keamanan

Nausea and/or vomiting, stomach pain, diarrhea, digestive problems (dyspepsia) are the most common symptoms of toxicity. More toxicity symptoms include dizziness, sleepiness, disturbed sleep, nervousness, headache, palpitations, flushing, stomach problems, constipation, dry mouth, flatulence, skin rash, tiredness, pain, feeling feverish and shivering, and malaise.

Severe toxicity can lead to thrombocytopenia and anemia with bleeding episodes. Dexketoprofen is associated with a small increased risk of myocardial infarction L1302.

Dexketoprofen

DB09214

small molecule approved investigational

Deskripsi

Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties L1298.

Struktur Molekul 2D

Berat 254.2806
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.65 h [L1299]
Volume Distribusi <0.25 L/kg [L1299]
Klirens (Clearance) Mainly cleared via glucuronide conjugation and followed by renal excretion, mainly unchanged [L1299].

Absorpsi

After oral ingestion, the Dexketoprofen onset of action is within 30 minutes. The plasma half-life of Dexketoprofen is about 4-6 hours. The Cmax is about 30 minutes L1304

Metabolisme

Dexketoprofen is highly lipophilic, and is metabolized in the liver by glucuronidation L1304. In one study, after oral administration of 25 mg of dexketoprofen to young healthy adults, Tmax was approximately 30 min for a Cmax of 3.7 ± 0.72 mg/l L1305. Dexketoprofen trometamol is metabolized by the hepatic cytochrome P450 enzymes (CYP2C8 and CYP2C9) L1305. Dexketoprofen trometamol has a number of metabolites, with hydroxyl derivatives making up the greatest volume L1305. In humans, hydroxylation plays a minor role. Dexketoprofen is primarily conjugated to an acyl-glucuronide L1305

Rute Eliminasi

Approximately 70 to 80% of the ingested dose is recovered in the urine during the first 12 hours post-ingestion, mainly as the acyl-conjugated form of the drug L1301.

Interaksi Obat

1458 Data
Amlodipine Dexketoprofen may decrease the antihypertensive activities of Amlodipine.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Dexketoprofen.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Dexketoprofen.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Dexketoprofen.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Dexketoprofen.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Dexketoprofen.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Dexketoprofen.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Dexketoprofen.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Dexketoprofen.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Dexketoprofen.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Dexketoprofen.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Dexketoprofen.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Dexketoprofen.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Dexketoprofen.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Dexketoprofen.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Dexketoprofen.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Dexketoprofen.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Dexketoprofen.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Dexketoprofen.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Dexketoprofen.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Dexketoprofen.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Dexketoprofen.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Dexketoprofen.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Dexketoprofen.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Dexketoprofen.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Dexketoprofen.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Dexketoprofen.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Dexketoprofen.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Dexketoprofen.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Dexketoprofen.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Dexketoprofen.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Dexketoprofen.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Dexketoprofen.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Dexketoprofen.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Dexketoprofen.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Dexketoprofen.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Dexketoprofen.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Dexketoprofen.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Dexketoprofen.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Dexketoprofen.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Dexketoprofen.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Dexketoprofen.
Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Dexketoprofen.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Dexketoprofen.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Dexketoprofen.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Dexketoprofen.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Dexketoprofen.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Dexketoprofen.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Dexketoprofen.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Dexketoprofen.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Dexketoprofen.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Dexketoprofen.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Dexketoprofen.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Dexketoprofen.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Dexketoprofen.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Dexketoprofen.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Dexketoprofen.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Dexketoprofen.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Dexketoprofen.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Dexketoprofen.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Dexketoprofen.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Dexketoprofen.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Dexketoprofen.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Dexketoprofen.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Dexketoprofen.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Dexketoprofen.
Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Dexketoprofen.
Zuclopenthixol The risk or severity of hypertension can be increased when Zuclopenthixol is combined with Dexketoprofen.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Dexketoprofen.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Dexketoprofen.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Dexketoprofen.
Iproniazid The risk or severity of hypertension can be increased when Iproniazid is combined with Dexketoprofen.
Nialamide The risk or severity of hypertension can be increased when Nialamide is combined with Dexketoprofen.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Lysergic acid diethylamide is combined with Dexketoprofen.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Dexketoprofen.
Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Dexketoprofen.
Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Dexketoprofen.
Indacaterol The risk or severity of hypertension can be increased when Indacaterol is combined with Dexketoprofen.
Rotigotine The risk or severity of hypertension can be increased when Rotigotine is combined with Dexketoprofen.
Amibegron The risk or severity of hypertension can be increased when Amibegron is combined with Dexketoprofen.
Naluzotan The risk or severity of hypertension can be increased when Naluzotan is combined with Dexketoprofen.
Cariprazine The risk or severity of hypertension can be increased when Cariprazine is combined with Dexketoprofen.
Mianserin The risk or severity of hypertension can be increased when Mianserin is combined with Dexketoprofen.
Pizotifen The risk or severity of hypertension can be increased when Pizotifen is combined with Dexketoprofen.
Solabegron The risk or severity of hypertension can be increased when Solabegron is combined with Dexketoprofen.
Asenapine The risk or severity of hypertension can be increased when Asenapine is combined with Dexketoprofen.
Safinamide The risk or severity of hypertension can be increased when Safinamide is combined with Dexketoprofen.
Esmirtazapine The risk or severity of hypertension can be increased when Esmirtazapine is combined with Dexketoprofen.
Vilazodone The risk or severity of hypertension can be increased when Vilazodone is combined with Dexketoprofen.
Nitrous oxide The risk or severity of hypertension can be increased when Nitrous oxide is combined with Dexketoprofen.
Xylometazoline The risk or severity of hypertension can be increased when Xylometazoline is combined with Dexketoprofen.
Dexmethylphenidate The risk or severity of hypertension can be increased when Dexmethylphenidate is combined with Dexketoprofen.
Isometheptene The risk or severity of hypertension can be increased when Isometheptene is combined with Dexketoprofen.
Levonordefrin The risk or severity of hypertension can be increased when Levonordefrin is combined with Dexketoprofen.
Tetryzoline The risk or severity of hypertension can be increased when Tetryzoline is combined with Dexketoprofen.
Cinitapride The risk or severity of hypertension can be increased when Cinitapride is combined with Dexketoprofen.
Lurasidone The risk or severity of hypertension can be increased when Lurasidone is combined with Dexketoprofen.
Tyramine The risk or severity of hypertension can be increased when Tyramine is combined with Dexketoprofen.
Adrafinil The risk or severity of hypertension can be increased when Adrafinil is combined with Dexketoprofen.
Isoxsuprine The risk or severity of hypertension can be increased when Isoxsuprine is combined with Dexketoprofen.

Target Protein

Prostaglandin G/H synthase 1 PTGS1
Prostaglandin G/H synthase 2 PTGS2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16801987
    Valles J, Artigas R, Crea A, Muller F, Paredes I, Zapata A, Capriati A: Clinical pharmacokinetics of parenteral dexketoprofen trometamol in healthy subjects. Methods Find Exp Clin Pharmacol. 2006 Jun;28 Suppl A:7-12.

Contoh Produk & Brand

Produk: 0 • International brands: 31
International Brands
  • ACTIDEX
  • DESKETO
  • DEXADOL
  • DEXAK
  • DEXALGIN
  • DEXAROM
  • DEXOFEN
  • DEXOKET
  • DEXOMEN
  • DEXPRO

Sekuens Gen/Protein (FASTA)

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