Peringatan Keamanan

The serotonin antagonists and reuptake inhibitors' side effects are minor with rare reports of cardiotoxicity. They have been reported to cause an unbalance between the sympathetic and parasympathetic system. There are also reports regarding a potential hepatotoxic effect of this drugs.T86

Lorpiprazole

DB09195

small molecule approved

Deskripsi

Lorpiprazole is a serotonin antagonist and reuptake inhibitor used for the treatment of major depressive disorder.A31634 It is a piperazinyl-triazole derivative.T83

Struktur Molekul 2D

Berat 405.469
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The estimated half-life for drugs like lorpiprazole, a serotonin antagonist and reuptake inhibitor, is in the range of 11-23 hours.[T86]
Volume Distribusi The serotonin antagonists and reuptake inhibitors as lorpiprazole are quickly distributed through the blood-brain-barrier getting concentrated in the brain to even higher levels than the ones found in plasma.[T86]
Klirens (Clearance) -

Absorpsi

After oral administration, the serotonin antagonist and reuptake inhibitors are rapidly absorbed in the gastrointestinal tract. This absorption can be slow down depending on the type of diet. The maximum plasma concentration of this kind of drugs occurs approximately 1 hour after administration.T86

Metabolisme

Serotonin antagonists and reuptake inhibitors like lorpiprazole are metabolized in the liver by the CYP450 isoenzymes, mainly CYP2D6 and CYP3A4.A31635

Rute Eliminasi

The elimination of drugs that fit in the category of serotonin antagonists and reuptake inhibitors like lorpiprazole is expected to have a biphasic profile in which most of the metabolized drug should be disposed of by the urine.T86

Interaksi Obat

1158 Data
Metoclopramide The risk or severity of serotonin syndrome and neuroleptic malignant syndrome can be increased when Lorpiprazole is combined with Metoclopramide.
Mirabegron The serum concentration of Lorpiprazole can be increased when it is combined with Mirabegron.
Tedizolid phosphate The risk or severity of serotonin syndrome can be increased when Tedizolid phosphate is combined with Lorpiprazole.
Chlorproethazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Chlorproethazine.
Reserpine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Reserpine.
Thiethylperazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Thiethylperazine.
Paliperidone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Paliperidone.
Blonanserin The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Blonanserin.
Methylene blue The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Methylene blue.
Tiapride The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Tiapride.
Fluphenazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Fluphenazine.
Remoxipride The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Remoxipride.
Mesoridazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Mesoridazine.
Olanzapine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Olanzapine.
Ziprasidone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Ziprasidone.
Risperidone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Risperidone.
Sulpiride The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Sulpiride.
Loxapine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Loxapine.
Promazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Promazine.
Prochlorperazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Prochlorperazine.
Droperidol The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Droperidol.
Triflupromazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Triflupromazine.
Moricizine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Moricizine.
Trifluoperazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Trifluoperazine.
Flupentixol The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Flupentixol.
Acetophenazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Acetophenazine.
Quetiapine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Quetiapine.
Aripiprazole The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Aripiprazole.
Chlorprothixene The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Chlorprothixene.
Alimemazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Alimemazine.
Periciazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Periciazine.
Acepromazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Acepromazine.
Aceprometazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Aceprometazine.
Molindone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Molindone.
Thioproperazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Thioproperazine.
Thiothixene The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Thiothixene.
Zuclopenthixol The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Zuclopenthixol.
Fluspirilene The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Fluspirilene.
Osanetant The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Osanetant.
Bifeprunox The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Bifeprunox.
Iloperidone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Iloperidone.
BL-1020 The risk or severity of adverse effects can be increased when Lorpiprazole is combined with BL-1020.
Cariprazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Cariprazine.
Lumateperone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Lumateperone.
Sertindole The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Sertindole.
Asenapine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Asenapine.
Amisulpride The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Amisulpride.
Lurasidone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Lurasidone.
Perospirone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Perospirone.
Amperozide The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Amperozide.
Cyamemazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Cyamemazine.
Brexpiprazole The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Brexpiprazole.
Zotepine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Zotepine.
Brilaroxazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Brilaroxazine.
Pipamperone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Pipamperone.
Azaperone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Azaperone.
Propiopromazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Propiopromazine.
Tetrahydropalmatine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Tetrahydropalmatine.
Ecopipam The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Ecopipam.
Bromperidol The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Bromperidol.
Raclopride The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Raclopride.
Perazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Perazine.
Benperidol The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Benperidol.
Prothipendyl The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Prothipendyl.
Butaperazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Butaperazine.
Clothiapine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Clothiapine.
Sultopride The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Sultopride.
Oxypertine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Oxypertine.
Thiazinam The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Thiazinam.
Veralipride The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Veralipride.
Trifluperidol The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Trifluperidol.
Moperone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Moperone.
Thiopropazate The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Thiopropazate.
Fluanisone The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Fluanisone.
Mosapramine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Mosapramine.
Dixyrazine The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Dixyrazine.
Penfluridol The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Penfluridol.
Clopenthixol The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Clopenthixol.
Aripiprazole lauroxil The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Aripiprazole lauroxil.
Perphenazine enanthate The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Perphenazine enanthate.
Lithium cation The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Lithium cation.
Levosulpiride The risk or severity of adverse effects can be increased when Lorpiprazole is combined with Levosulpiride.
Quinine The metabolism of Lorpiprazole can be decreased when combined with Quinine.
Celecoxib The metabolism of Lorpiprazole can be decreased when combined with Celecoxib.
Fluvoxamine The metabolism of Lorpiprazole can be decreased when combined with Fluvoxamine.
Metoprolol The metabolism of Lorpiprazole can be decreased when combined with Metoprolol.
Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Lorpiprazole.
Clozapine The serum concentration of Lorpiprazole can be increased when it is combined with Clozapine.
Duloxetine The metabolism of Lorpiprazole can be decreased when combined with Duloxetine.
Chlorpromazine The metabolism of Lorpiprazole can be decreased when combined with Chlorpromazine.
Cimetidine Cimetidine may decrease the excretion rate of Lorpiprazole which could result in a higher serum level.
Chloroquine The metabolism of Lorpiprazole can be decreased when combined with Chloroquine.
Nicardipine The metabolism of Lorpiprazole can be decreased when combined with Nicardipine.
Primaquine The metabolism of Lorpiprazole can be decreased when combined with Primaquine.
Fusidic acid The metabolism of Lorpiprazole can be decreased when combined with Fusidic acid.
Cholecalciferol The metabolism of Lorpiprazole can be decreased when combined with Cholecalciferol.
Tranylcypromine The metabolism of Lorpiprazole can be decreased when combined with Tranylcypromine.
Perhexiline The metabolism of Lorpiprazole can be decreased when combined with Perhexiline.
Tegaserod The metabolism of Lorpiprazole can be decreased when combined with Tegaserod.
Abiraterone The metabolism of Lorpiprazole can be decreased when combined with Abiraterone.

Target Protein

5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 2C HTR2C
Alpha-1 adrenergic receptors ADRA1A
Alpha-2 adrenergic receptors ADRA2A
Histamine H1 receptor HRH1
Sodium-dependent serotonin transporter SLC6A4

Referensi & Sumber

Artikel (PubMed)
Textbook
  • Elks J. and Ganellin C.R. (1990). The dictionary of drugs. Springer Science.
  • Clark M., Harvey R., Finkel R., Rey J. and Whalen K. (2011). Pharmacology (5th ed.). Lippincott Williams & Wilkins.
  • Szyndler J., Skorzewska A. and Plaznik A. (2003). Pharmacotherapy in psychiatry and neurology (3rd ed.). Institute of psychiatry and neurology.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Normarex

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