Lofentanil

DB09174

small molecule illicit

Deskripsi

Lofentanil is an analog of fentanyl and is one of the most potent opioids available today. It displays most similarity to carfentanil (4-carbomethoxyfentanyl) and is considered to be slightly more potent than this drug.

Struktur Molekul 2D

Berat 408.542
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

915 Data
Buprenorphine Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
Hydrocodone Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
Magnesium sulfate The therapeutic efficacy of Lofentanil can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Lofentanil may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
Orphenadrine Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
Pramipexole Lofentanil may increase the sedative activities of Pramipexole.
Ropinirole Lofentanil may increase the sedative activities of Ropinirole.
Rotigotine Lofentanil may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Lofentanil.
Sodium oxybate Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
Thalidomide Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Alvimopan The risk or severity of adverse effects can be increased when Lofentanil is combined with Alvimopan.
Desmopressin The risk or severity of hyponatremia can be increased when Lofentanil is combined with Desmopressin.
Morphine The risk or severity of adverse effects can be increased when Morphine is combined with Lofentanil.
Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Lofentanil.
Hydromorphone The risk or severity of adverse effects can be increased when Hydromorphone is combined with Lofentanil.
Meperidine The risk or severity of adverse effects can be increased when Meperidine is combined with Lofentanil.
Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Lofentanil.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Lofentanil.
Naltrexone The therapeutic efficacy of Lofentanil can be decreased when used in combination with Naltrexone.
Sufentanil The risk or severity of adverse effects can be increased when Sufentanil is combined with Lofentanil.
Alfentanil The risk or severity of adverse effects can be increased when Alfentanil is combined with Lofentanil.
Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Lofentanil.
Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Lofentanil.
Remifentanil The risk or severity of adverse effects can be increased when Remifentanil is combined with Lofentanil.
Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Lofentanil.
Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Lofentanil.
Dezocine The risk or severity of adverse effects can be increased when Dezocine is combined with Lofentanil.
Methadyl acetate The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Lofentanil.
Dihydroetorphine The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Lofentanil.
Diamorphine The risk or severity of adverse effects can be increased when Diamorphine is combined with Lofentanil.
Bezitramide The risk or severity of adverse effects can be increased when Bezitramide is combined with Lofentanil.
Ethylmorphine The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Lofentanil.
Etorphine The risk or severity of adverse effects can be increased when Etorphine is combined with Lofentanil.
Dextromoramide The risk or severity of adverse effects can be increased when Dextromoramide is combined with Lofentanil.
Desomorphine The risk or severity of adverse effects can be increased when Desomorphine is combined with Lofentanil.
Carfentanil The risk or severity of adverse effects can be increased when Carfentanil is combined with Lofentanil.
Dihydrocodeine The risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Lofentanil.
Alphacetylmethadol The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Lofentanil.
Dihydromorphine The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Lofentanil.
Ketobemidone The risk or severity of adverse effects can be increased when Ketobemidone is combined with Lofentanil.
DPDPE The risk or severity of adverse effects can be increased when DPDPE is combined with Lofentanil.
Opium The risk or severity of adverse effects can be increased when Lofentanil is combined with Opium.
Normethadone The risk or severity of adverse effects can be increased when Lofentanil is combined with Normethadone.
Piritramide The risk or severity of adverse effects can be increased when Lofentanil is combined with Piritramide.
Alphaprodine The risk or severity of adverse effects can be increased when Lofentanil is combined with Alphaprodine.
Nicomorphine The risk or severity of adverse effects can be increased when Lofentanil is combined with Nicomorphine.
Meptazinol The therapeutic efficacy of Lofentanil can be decreased when used in combination with Meptazinol.
Phenoperidine The risk or severity of adverse effects can be increased when Lofentanil is combined with Phenoperidine.
Phenazocine The risk or severity of adverse effects can be increased when Lofentanil is combined with Phenazocine.
Tilidine The risk or severity of adverse effects can be increased when Lofentanil is combined with Tilidine.
Carfentanil, C-11 The risk or severity of adverse effects can be increased when Lofentanil is combined with Carfentanil, C-11.
Naloxegol The risk or severity of adverse effects can be increased when Naloxegol is combined with Lofentanil.
Benzhydrocodone The risk or severity of adverse effects can be increased when Lofentanil is combined with Benzhydrocodone.
Pegvisomant The therapeutic efficacy of Pegvisomant can be decreased when used in combination with Lofentanil.
Succinylcholine The risk or severity of bradycardia can be increased when Succinylcholine is combined with Lofentanil.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Lofentanil.
Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Lofentanil.
Mirtazapine Lofentanil may increase the serotonergic activities of Mirtazapine.
Fluvoxamine The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Fluvoxamine.
Citalopram The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Citalopram.
Duloxetine The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Duloxetine.
Paroxetine The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Paroxetine.
Sertraline The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Sertraline.
Sibutramine The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Sibutramine.
Nefazodone The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Nefazodone.
Zimelidine The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Zimelidine.
Dapoxetine The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Dapoxetine.
Milnacipran The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Milnacipran.
Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Lofentanil.
Seproxetine The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Seproxetine.
Levomilnacipran The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Levomilnacipran.
Indalpine The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Indalpine.
Ritanserin The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Ritanserin.
Alaproclate The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Alaproclate.
Ethanol Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Lofentanil may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
Phentermine Phentermine may increase the analgesic activities of Lofentanil.
Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Lofentanil.
Benzphetamine Benzphetamine may increase the analgesic activities of Lofentanil.
Diethylpropion Diethylpropion may increase the analgesic activities of Lofentanil.
Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Lisdexamfetamine.
Mephentermine Mephentermine may increase the analgesic activities of Lofentanil.
MMDA MMDA may increase the analgesic activities of Lofentanil.
Midomafetamine Midomafetamine may increase the analgesic activities of Lofentanil.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Lofentanil.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Lofentanil.

Target Protein

Mu-type opioid receptor OPRM1
Kappa-type opioid receptor OPRK1
Delta-type opioid receptor OPRD1

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

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