Peringatan Keamanan

The LD₅₀ of butyrfentanyl is not readily available.^L7817

Patients experiencing an overdose may present with sedation, altered mental state, and difficulty breathing.^A182069 Symptoms of overdose may be treated with naloxone and supportive measures.^A182069

Butyrfentanyl

DB09173

small molecule illicit

Deskripsi

Butyrfentanyl or butyrylfentanyl (not to be confused with 3-methylfentanyl) is a potent short-acting synthetic opioid analgesic drug.^A182054 It is an analog of fentanyl with roughly 1/30 the potency.^L7811 Butyrfentanyl was first synthesized in 1961 by Janssen Pharmaceuticals as a new opioid analgesic.^L7811

Butyrfentanyl has no current legitimate clinical applications, but anecdotal reports indicate it may occasionally be surfacing on the grey-market as a recreational drug.^L7811 This compound is a schedule I controlled substance in the USA because it is a positional isomer of 3-Methylfentanyl.^L7814

The DEA in the United States has confirmed at least 40 fatalities involving butyrfentanyl before May 2016.^L7811

Struktur Molekul 2D

Berat 350.506

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Data for the half life of butyrfentanyl are not readily available.

Volume Distribusi Data for the volume of distribution of butyrfentanyl are not readily available.

Klirens (Clearance) Data for the clearance of butyrfentanyl are not readily available.

Absorpsi

Data for the absorption of butyrfentanyl are not readily available.

Metabolisme

Butyrfentanyl can be N-dealkylated to nor-butyrfentanyl by CYP3A4 and CYP2D6, hydroxylated to (?-1)-hydroxy-butyrfentanyl by CYP3A4, 4'-hydroxylated to 4'-hydroxy-butyrfentanyl, hydroxylated to ?-hydroxy-butyrfentanyl bye CYP2D6 or CYP3A4, or hydroxylated to ?-hydroxy-butyrfentanyl by CYP3A4.^A182054 ?-hydroxy-butyrfentanyl is further metabolized to ?-carboxy-butyrfentanyl while 4'-hydroxy-butyrfentanyl is further metabolized to 4'-hydroxy-3'-methoxy-butyrfentanyl.^A182054 Many of these metabolites may undergo further conjugation reactions with glucuronic acid or sulfate.^A182054

Rute Eliminasi

The route of elimination of butyrfentanyl has not been well described in the literature but most opioids are mainly eliminated in the urine.^A34546

Interaksi Obat

354 Data

Mirabegron	The serum concentration of Butyrfentanyl can be increased when it is combined with Mirabegron.
Cyclosporine	The metabolism of Butyrfentanyl can be decreased when combined with Cyclosporine.
Cholecalciferol	The metabolism of Butyrfentanyl can be decreased when combined with Cholecalciferol.
Fluvoxamine	The metabolism of Butyrfentanyl can be decreased when combined with Fluvoxamine.
Metoprolol	The metabolism of Butyrfentanyl can be decreased when combined with Metoprolol.
Venlafaxine	The metabolism of Butyrfentanyl can be decreased when combined with Venlafaxine.
Terfenadine	The metabolism of Butyrfentanyl can be decreased when combined with Terfenadine.
Clobazam	The serum concentration of Butyrfentanyl can be increased when it is combined with Clobazam.
Clozapine	The serum concentration of Butyrfentanyl can be increased when it is combined with Clozapine.
Imipramine	The metabolism of Butyrfentanyl can be decreased when combined with Imipramine.
Quinine	The metabolism of Butyrfentanyl can be decreased when combined with Quinine.
Duloxetine	The metabolism of Butyrfentanyl can be decreased when combined with Duloxetine.
Chlorpromazine	The metabolism of Butyrfentanyl can be decreased when combined with Chlorpromazine.
Celecoxib	The metabolism of Butyrfentanyl can be decreased when combined with Celecoxib.
Darifenacin	The metabolism of Butyrfentanyl can be decreased when combined with Darifenacin.
Cimetidine	The metabolism of Butyrfentanyl can be decreased when combined with Cimetidine.
Ritonavir	The metabolism of Butyrfentanyl can be decreased when combined with Ritonavir.
Chloroquine	The metabolism of Butyrfentanyl can be decreased when combined with Chloroquine.
Delavirdine	The metabolism of Butyrfentanyl can be decreased when combined with Delavirdine.
Tranylcypromine	The metabolism of Butyrfentanyl can be decreased when combined with Tranylcypromine.
Terbinafine	The metabolism of Butyrfentanyl can be decreased when combined with Terbinafine.
Tipranavir	The metabolism of Butyrfentanyl can be decreased when combined with Tipranavir.
Ketoconazole	The metabolism of Butyrfentanyl can be decreased when combined with Ketoconazole.
Perhexiline	The metabolism of Butyrfentanyl can be decreased when combined with Perhexiline.
Tegaserod	The metabolism of Butyrfentanyl can be decreased when combined with Tegaserod.
Desipramine	The metabolism of Butyrfentanyl can be decreased when combined with Desipramine.
Fusidic acid	The metabolism of Butyrfentanyl can be decreased when combined with Fusidic acid.
Abiraterone	The metabolism of Butyrfentanyl can be decreased when combined with Abiraterone.
Panobinostat	The metabolism of Butyrfentanyl can be decreased when combined with Panobinostat.
Vilazodone	The metabolism of Butyrfentanyl can be decreased when combined with Vilazodone.
Lumefantrine	The metabolism of Butyrfentanyl can be decreased when combined with Lumefantrine.
Sulfaphenazole	The metabolism of Butyrfentanyl can be decreased when combined with Sulfaphenazole.
Phenylbutyric acid	The metabolism of Butyrfentanyl can be decreased when combined with Phenylbutyric acid.
Dosulepin	The metabolism of Butyrfentanyl can be decreased when combined with Dosulepin.
Manidipine	The metabolism of Butyrfentanyl can be decreased when combined with Manidipine.
Rolapitant	The metabolism of Butyrfentanyl can be decreased when combined with Rolapitant.
Asunaprevir	The metabolism of Butyrfentanyl can be decreased when combined with Asunaprevir.
Pitolisant	The metabolism of Butyrfentanyl can be decreased when combined with Pitolisant.
Rucaparib	The metabolism of Butyrfentanyl can be decreased when combined with Rucaparib.
Ritanserin	The metabolism of Butyrfentanyl can be decreased when combined with Ritanserin.
Rhein	The metabolism of Butyrfentanyl can be decreased when combined with Rhein.
Primaquine	The metabolism of Butyrfentanyl can be decreased when combined with Primaquine.
Lorcaserin	The metabolism of Butyrfentanyl can be decreased when combined with Lorcaserin.
Nicardipine	The metabolism of Butyrfentanyl can be decreased when combined with Nicardipine.
Berotralstat	The metabolism of Butyrfentanyl can be decreased when combined with Berotralstat.
Cisapride	The metabolism of Butyrfentanyl can be decreased when combined with Cisapride.
Thioridazine	The metabolism of Butyrfentanyl can be decreased when combined with Thioridazine.
Paroxetine	The metabolism of Butyrfentanyl can be decreased when combined with Paroxetine.
Quinidine	The metabolism of Butyrfentanyl can be decreased when combined with Quinidine.
Cinacalcet	The metabolism of Butyrfentanyl can be decreased when combined with Cinacalcet.
Bupropion	The metabolism of Butyrfentanyl can be decreased when combined with Bupropion.
Orphenadrine	The metabolism of Butyrfentanyl can be decreased when combined with Orphenadrine.
Propafenone	The metabolism of Butyrfentanyl can be decreased when combined with Propafenone.
Halofantrine	The metabolism of Butyrfentanyl can be decreased when combined with Halofantrine.
Methotrimeprazine	The metabolism of Butyrfentanyl can be decreased when combined with Methotrimeprazine.
Glycerol phenylbutyrate	The metabolism of Butyrfentanyl can be decreased when combined with Glycerol phenylbutyrate.
Ticlopidine	The metabolism of Butyrfentanyl can be decreased when combined with Ticlopidine.
Citalopram	The metabolism of Butyrfentanyl can be decreased when combined with Citalopram.
Lidocaine	The metabolism of Butyrfentanyl can be decreased when combined with Lidocaine.
Clemastine	The metabolism of Butyrfentanyl can be decreased when combined with Clemastine.
Methadone	The metabolism of Butyrfentanyl can be decreased when combined with Methadone.
Cerivastatin	The metabolism of Butyrfentanyl can be decreased when combined with Cerivastatin.
Hydroxyzine	The metabolism of Butyrfentanyl can be decreased when combined with Hydroxyzine.
Fenfluramine	The metabolism of Butyrfentanyl can be decreased when combined with Fenfluramine.
Labetalol	The metabolism of Butyrfentanyl can be decreased when combined with Labetalol.
Dexmedetomidine	The metabolism of Butyrfentanyl can be decreased when combined with Dexmedetomidine.
Dextropropoxyphene	The metabolism of Butyrfentanyl can be decreased when combined with Dextropropoxyphene.
Tripelennamine	The metabolism of Butyrfentanyl can be decreased when combined with Tripelennamine.
Biperiden	The metabolism of Butyrfentanyl can be decreased when combined with Biperiden.
Mifepristone	The metabolism of Butyrfentanyl can be decreased when combined with Mifepristone.
Perphenazine	The metabolism of Butyrfentanyl can be decreased when combined with Perphenazine.
Ranitidine	The metabolism of Butyrfentanyl can be decreased when combined with Ranitidine.
Cocaine	The metabolism of Butyrfentanyl can be decreased when combined with Cocaine.
Doxorubicin	The metabolism of Butyrfentanyl can be decreased when combined with Doxorubicin.
Promethazine	The metabolism of Butyrfentanyl can be decreased when combined with Promethazine.
Diphenhydramine	The metabolism of Butyrfentanyl can be decreased when combined with Diphenhydramine.
Miconazole	The metabolism of Butyrfentanyl can be decreased when combined with Miconazole.
Chlorpheniramine	The metabolism of Butyrfentanyl can be decreased when combined with Chlorpheniramine.
Moclobemide	The metabolism of Butyrfentanyl can be decreased when combined with Moclobemide.
Acebutolol	The metabolism of Butyrfentanyl can be decreased when combined with Acebutolol.
Metoclopramide	The metabolism of Butyrfentanyl can be decreased when combined with Metoclopramide.
Mibefradil	The metabolism of Butyrfentanyl can be decreased when combined with Mibefradil.
Oxprenolol	The metabolism of Butyrfentanyl can be decreased when combined with Oxprenolol.
Hydroxychloroquine	The metabolism of Butyrfentanyl can be decreased when combined with Hydroxychloroquine.
Pipotiazine	The metabolism of Butyrfentanyl can be decreased when combined with Pipotiazine.
Iproniazid	The metabolism of Butyrfentanyl can be decreased when combined with Iproniazid.
Rotigotine	The metabolism of Butyrfentanyl can be decreased when combined with Rotigotine.
Indisulam	The metabolism of Butyrfentanyl can be decreased when combined with Indisulam.
Sparteine	The metabolism of Butyrfentanyl can be decreased when combined with Sparteine.
Rilpivirine	The metabolism of Butyrfentanyl can be decreased when combined with Rilpivirine.
Stiripentol	The metabolism of Butyrfentanyl can be decreased when combined with Stiripentol.
Melperone	The metabolism of Butyrfentanyl can be decreased when combined with Melperone.
Dexchlorpheniramine maleate	The metabolism of Butyrfentanyl can be decreased when combined with Dexchlorpheniramine maleate.
Isavuconazole	The metabolism of Butyrfentanyl can be decreased when combined with Isavuconazole.
Artenimol	The metabolism of Butyrfentanyl can be decreased when combined with Artenimol.
Diacerein	The metabolism of Butyrfentanyl can be decreased when combined with Diacerein.
Triclabendazole	The metabolism of Butyrfentanyl can be decreased when combined with Triclabendazole.
Dexchlorpheniramine	The metabolism of Butyrfentanyl can be decreased when combined with Dexchlorpheniramine.
Black cohosh	The metabolism of Butyrfentanyl can be decreased when combined with Black cohosh.
Verapamil	The metabolism of Butyrfentanyl can be decreased when combined with Verapamil.

Target Protein

Mu-type opioid receptor OPRM1

Kappa-type opioid receptor OPRK1

Delta-type opioid receptor OPRD1

Referensi & Sumber

Synthesis reference: Janssen PAJ. 1-Aralkyl-4-(N-aryl-carbonyl amino)piperidines and related compounds. US Patent No. US3164600 (January 5, 1965). 1965.

Artikel (PubMed)

PMID: 30930421
Kanamori T, Iwata YT, Segawa H, Yamamuro T, Kuwayama K, Tsujikawa K, Inoue H: Metabolism of Butyrylfentanyl in Fresh Human Hepatocytes: Chemical Synthesis of Authentic Metabolite Standards for Definitive Identification. Biol Pharm Bull. 2019;42(4):623-630. doi: 10.1248/bpb.b18-00765.
PMID: 28807672
Baumann MH, Majumdar S, Le Rouzic V, Hunkele A, Uprety R, Huang XP, Xu J, Roth BL, Pan YX, Pasternak GW: Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace. Neuropharmacology. 2018 May 15;134(Pt A):101-107. doi: 10.1016/j.neuropharm.2017.08.016. Epub 2017 Aug 12.
PMID: 19567715
Smith HS: Opioid metabolism. Mayo Clin Proc. 2009 Jul;84(7):613-24. doi: 10.1016/S0025-6196(11)60750-7.
PMID: 25713275
Cole JB, Dunbar JF, McIntire SA, Regelmann WE, Slusher TM: Butyrfentanyl overdose resulting in diffuse alveolar hemorrhage. Pediatrics. 2015 Mar;135(3):e740-3. doi: 10.1542/peds.2014-2878.
PMID: 25314012
Bista SR, Haywood A, Hardy J, Lobb M, Tapuni A, Norris R: Protein binding of fentanyl and its metabolite nor-fentanyl in human plasma, albumin and alpha-1 acid glycoprotein. Xenobiotica. 2015 Mar;45(3):207-12. doi: 10.3109/00498254.2014.971093. Epub 2014 Oct 14.

Link

Contoh Produk & Brand

Produk: 0 • International brands: 0

Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.