Peringatan Keamanan

No long-term animal studies have been performed to evaluate carcinogenic potential or whether Technetium Tc99m Disofenin affects fertility in males or females. There is reported evidence of reproductive toxicity as well as mutagenicity in human leukocytes in vitro. LD50 value in rats following intravenous injection is 7.8mg/kg. Adverse effects from injection include itching at the site of injection progressing to erythema multiforme, and rare cases of nausea and chills.

Technetium Tc-99m disofenin

DB09164

small molecule approved

Deskripsi

Technetium Tc-99m disofenin is a radiopharmaceutical agent used in hepatobiliary imaging for diagnostic purposes. It is well suited for both planar and single photon tomographic scintigraphy to quantitatively measure the function of liver, gallbladder and bile ducts and detect any anatomical changes in the hepatobliary system. It is available as an intravenous injection in a preparation kit under the name Hepatolite. Technetium Tc-99m is a metastable nuclear isomer and disofenin is an iminodiacetic acid derivative with no known pharmacologic actions at the doses recommended. However disofenin is the most commonly used iminodiacetic acid since it has a high liver to renal extraction and its hepatic uptake is not as highly dependent on serum bilirubin levels (a competitive inhibitor for liver uptake) as are other tracers from the iminodiacetic acid.

Struktur Molekul 2D

Berat 449.321
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Technetium Tc99m decays by isomeric transition with a physical half-life of 6.02 hours [L794] but the Technetium Tc99M disofenin complex displays a hepatic elimination half life of 19 minutes [A18523].
Volume Distribusi Technetium Tc99M disofenin is distributed to various tissues including blood, kidney, liver, urinary bladder and predominantly stomach and intestines [A19428].
Klirens (Clearance) Technetium Tc 99M Disofenin is rapidly cleared from the circulation of normal individuals following intravenous administration; about 8% of the injected activity remains in the circulation 30 minutes post-injection. As the serum bilirubin level increases, the blood clearance becomes progressively delayed [L794].

Absorpsi

In fasting normal individuals, peak liver uptake occurs by 10 minutes post-injection and peak gallbladder accumulation by 30-40 minutes post-injection L794. Hepatic uptake is about 88%.

Metabolisme

It undergoes radioactive decay.

Rute Eliminasi

About 9% of the administered activity is excreted in the urine over the first two hours post-injection. The remainder of the activity is essentially quantitatively cleared through the hepatobiliary system L794. Technetium Tc99M disofenin is excreted into the intrahepatic biliary ducts via active transport and is further taken to the extrahepatic bile via choleresis. It may enter the duodenum directly or be stored in the gallbladder for later release. Once inside the intestines, DISIDA does not enter the enterohepatic circulation A19423.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach. This diagnostic agent should be administered to fasted patients (ideally at least 4 hours post-intake).

Interaksi Obat

0 Data
Tidak ada data.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17374583
    Xia CS, Yang XY, Hong GX: 99Tcm-DISIDA hepatobiliary imaging in evaluating gallbladder function in patients with spinal cord injury. Hepatobiliary Pancreat Dis Int. 2007 Apr;6(2):204-7.
  • PMID: 3585600
    Spivak W, Sarkar S, Winter D, Glassman M, Donlon E, Tucker KJ: Diagnostic utility of hepatobiliary scintigraphy with 99mTc-DISIDA in neonatal cholestasis. J Pediatr. 1987 Jun;110(6):855-61.
  • PMID: 2769404
    Gambhir SS, Hawkins RA, Huang SC, Hall TR, Busuttil RW, Phelps ME: Tracer kinetic modeling approaches for the quantification of hepatic function with technetium-99m DISIDA and scintigraphy. J Nucl Med. 1989 Sep;30(9):1507-18.
  • PMID: 12483393
    Fong YC, Hsu HC, Sun SS, Kao A, Lin CC, Lee CC: Impaired gallbladder function in spinal cord injury on quantitative Tc-99m DISIDA cholescintigraphy. Abdom Imaging. 2003 Jan-Feb;28(1):87-91.
  • PMID: 3349693
    Ascher SA, Sarkar SD, Spivak WB: Hepatic uptake of technetium-99m diisopropyl iminodiacetic acid (DISIDA) is not impaired by very high serum bilirubin levels. Clin Nucl Med. 1988 Jan;13(1):1-3.
  • PMID: 2184521
    Krishnamurthy GT, Turner FE: Pharmacokinetics and clinical application of technetium 99m-labeled hepatobiliary agents. Semin Nucl Med. 1990 Apr;20(2):130-49.
  • PMID: 2642291
    Krishnamurthy S, Krishnamurthy GT: Technetium-99m-iminodiacetic acid organic anions: review of biokinetics and clinical application in hepatology. Hepatology. 1989 Jan;9(1):139-53.
  • PMID: 6281914
    Chervu LR, Nunn AD, Loberg MD: Radiopharmaceuticals for hepatobiliary imaging. Semin Nucl Med. 1982 Jan;12(1):5-17.

Contoh Produk & Brand

Produk: 1 • International brands: 1
Produk
  • Kit for the Preparation of Technetium Tc99m Disofenin
    Injection, powder, lyophilized, for solution • 20 mg/10mL • Intravenous • US • Approved
International Brands
  • Hepatolite

Sekuens Gen/Protein (FASTA)

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