Peringatan Keamanan

The following adverse reactions have been reported in > 0.5% of patients: signs and symptoms consistent with seizure occurring shortly after administration of the agent; transient arthritis; angioedema, arrhythmia, dizziness, syncope, abdominal pain, vomiting, and severe hypersensitivity characterized by dyspnea, hypotension, bradycardia, asthenia, and vomiting within two hours after a second injection of Technetium Tc 99m Sestamibi. A few cases of flushing, edema, injection site inflammation, dry mouth, fever, pruritis, rash, urticaria and fatigue have also been attributed to administration of the agent.

Technetium Tc-99m sestamibi

DB09161

small molecule approved investigational

Deskripsi

Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six methoxyisobutylisonitrile (MIBI) ligands, hence the name sesta (6) MIBI.. Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and/or breast tissue. The mechanism by which sestamibi localizes to these tissues has not been established. Single photon emission computed tomography (SPECT) is then performed to detect the gamma ray emmitted by the decay of Technetium-99m to Technetium-99.

Currently available within a preparation kit for injection, Technetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.

Struktur Molekul 2D

Berat 775.96
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Technetium Tc 99m decays by isomeric transition with a physical half-life of 6.02 hours. Blood clearance studies indicate that the fast clearing component clears with a t½ of 4.3 minutes at rest, and clears with a t½ of 1.6 minutes under exercise conditions. The myocardial biological half-life is approximately six hours after a rest or exercise injection. The biological half-life for the liver is approximately 30 minutes after a rest or exercise injection.
Volume Distribusi -
Klirens (Clearance) The effective half-life of clearance (which includes both the biological half-life and radionuclide decay) for the heart is approximately 3 hours, and for the liver is approximately 30 minutes, after a rest or exercise injection.

Absorpsi

At five minutes post injection about 8% of the injected dose remains in circulation. Myocardial uptake which is coronary flow dependent is 1.2% of the injected dose at rest and 1.5% of the injected dose at exercise.

Metabolisme

The agent is excreted without any evidence of metabolism.

Rute Eliminasi

The major pathway for clearance of Tc 99m Sestamibi is the hepatobiliary system. Activity from the gall bladder appears in the intestines within one hour of injection. Twenty-seven percent of the injected dose is excreted in the urine, and approximately thirty-three percent of the injected dose is cleared through the feces in 48 hours.

Interaksi Obat

236 Data
Ranolazine The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ranolazine.
Lumacaftor The serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Lumacaftor.
Vemurafenib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Vemurafenib.
Apalutamide The serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Apalutamide.
Pitolisant The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Pitolisant.
Isavuconazole The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Isavuconazole.
Isavuconazonium The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Isavuconazonium.
Fluconazole The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fluconazole.
Erythromycin The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Erythromycin.
Sildenafil The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Sildenafil.
Reserpine The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Reserpine.
Sorafenib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Sorafenib.
Loxapine The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Loxapine.
Quinine The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Quinine.
Ritonavir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ritonavir.
Toremifene The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Toremifene.
Verapamil The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Verapamil.
Tamoxifen The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Tamoxifen.
Mifepristone The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Mifepristone.
Vardenafil The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Vardenafil.
Tacrolimus The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Tacrolimus.
Conivaptan The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Conivaptan.
Quinidine The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Quinidine.
Zonisamide The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Zonisamide.
Tipranavir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Tipranavir.
Ketoconazole The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ketoconazole.
Amiodarone The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Amiodarone.
Carvedilol The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Carvedilol.
Itraconazole The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Itraconazole.
Propafenone The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Propafenone.
Clarithromycin The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Clarithromycin.
Saquinavir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Saquinavir.
Lapatinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lapatinib.
Paliperidone The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Paliperidone.
Mibefradil The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Mibefradil.
Lopinavir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lopinavir.
Biricodar The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Biricodar.
Dronedarone The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dronedarone.
Nilotinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Nilotinib.
Elacridar The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Elacridar.
Flibanserin The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Flibanserin.
Vandetanib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Vandetanib.
Telaprevir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Telaprevir.
Zosuquidar The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Zosuquidar.
Tariquidar The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Tariquidar.
Temsirolimus The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Temsirolimus.
Simeprevir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Simeprevir.
Brefeldin A The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Brefeldin A.
Ticagrelor The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ticagrelor.
Ivacaftor The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ivacaftor.
Lomitapide The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lomitapide.
Crizotinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Crizotinib.
Linagliptin The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Linagliptin.
Regorafenib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Regorafenib.
Ponatinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ponatinib.
Canagliflozin The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Canagliflozin.
Afatinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Afatinib.
Ledipasvir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ledipasvir.
Vorapaxar The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Vorapaxar.
Suvorexant The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Suvorexant.
Netupitant The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Netupitant.
Cobicistat The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Cobicistat.
Palbociclib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Palbociclib.
Daclatasvir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Daclatasvir.
Niguldipine The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Niguldipine.
Rolapitant The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Rolapitant.
Venetoclax The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Venetoclax.
Velpatasvir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Velpatasvir.
Neratinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Neratinib.
Valspodar The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Valspodar.
Dacomitinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dacomitinib.
Glasdegib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Glasdegib.
Voxilaprevir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Voxilaprevir.
Sarecycline The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Sarecycline.
Laniquidar The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Laniquidar.
Enasidenib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Enasidenib.
Pibrentasvir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Pibrentasvir.
Glecaprevir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Glecaprevir.
Dexniguldipine The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dexniguldipine.
ONT-093 The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with ONT-093.
Entrectinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Entrectinib.
Fedratinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fedratinib.
Istradefylline The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Istradefylline.
Norgestimate The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Norgestimate.
Carfilzomib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Carfilzomib.
Asunaprevir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Asunaprevir.
Favipiravir The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Favipiravir.
Methylene blue The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Methylene blue.
Ripretinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ripretinib.
Pralsetinib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Pralsetinib.
Lonafarnib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lonafarnib.
Clofazimine The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Clofazimine.
Arsenic trioxide The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Arsenic trioxide.
Mefloquine The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Mefloquine.
Cethromycin The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Cethromycin.
Ixabepilone The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ixabepilone.
Voclosporin The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Voclosporin.
Eliglustat The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Eliglustat.
Umbralisib The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Umbralisib.
Diosmin The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Diosmin.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 9472628
    Hendrikse NH, Franssen EJ, van der Graaf WT, Meijer C, Piers DA, Vaalburg W, de Vries EG: 99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein. Br J Cancer. 1998;77(3):353-8.
  • PMID: 25250628
    Ma Q, Chen B, Gao S, Ji T, Wen Q, Song Y, Zhu L, Xu Z, Liu L: 99mTc-3P4-RGD2 scintimammography in the assessment of breast lesions: comparative study with 99mTc-MIBI. PLoS One. 2014 Sep 24;9(9):e108349. doi: 10.1371/journal.pone.0108349. eCollection 2014.
  • PMID: 9591588
    Tiling R, Tatsch K, Sommer H, Meyer G, Pechmann M, Gebauer K, Munzing W, Linke R, Khalkhali I, Hahn K: Technetium-99m-sestamibi scintimammography for the detection of breast carcinoma: comparison between planar and SPECT imaging. J Nucl Med. 1998 May;39(5):849-56.

Contoh Produk & Brand

Produk: 5 • International brands: 0
Produk
  • Kit for the Preparation of Technetium Tc99m Sestamibi
    Injection, powder, lyophilized, for solution • 1 mg/5mL • Parenteral • US • Generic • Approved
  • Kit for the Preparation of Technetium Tc99m Sestamibi
    Injection • 1 mg/10mL • Intravenous • US • Generic • Approved
  • Technetium Tc 99m Sestamibi
    Injection • 1 mg/10mL • Intravenous • US • Approved
  • Technetium Tc 99m Sestamibi
    Injection, powder, for solution • 1 mg/1mL • Intravenous • US • Generic • Approved
  • Technetium Tc 99m Sestamibi
    Injection • 1 mg/1mL • Intravenous • US • Generic • Approved

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