There are no data on iopromide use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. Iopromide crosses the placenta and reaches fetal tissues in small amounts. In animal reproduction studies, intravenous administration of iopromide to pregnant rats and rabbits during organogenesis at doses up to 0.35 and 0.7 times, respectively, the maximum recommended human dose based on body surface area resulted in no relevant adverse developmental effects.L46906
The safety and efficacy of iopromide have been established in pediatric patients aged 2 years and older for radiographic evaluation of cardiac chambers and related arteries, excretory urography, and contrast computed tomography of the head and body. The use of iopromide in these age groups for these indications is supported by evidence from adequate and well-controlled studies in adults and additional safety data in pediatric patients aged 2 years and older, including data from published studies.L46906
Pediatric patients who are at higher risk of experiencing an adverse reaction during and after the administration of any contrast agent include those with asthma, sensitivity to medication and/or allergens, cyanotic and acyanotic heart disease, congestive
heart failure, or serum creatinine greater than 1.5 mg/dL.L46906
Thyroid function tests indicative of thyroid dysfunction, characterized by hypothyroidism or transient thyroid suppression have been reported following iodinated contrast media administration in pediatric patients, including term and preterm neonates; Some patients were treated for hypothyroidism. After exposure to iodinated contrast media, individualize thyroid function monitoring in pediatric patients 0 to 3 years of age based on underlying risk factors, especially in term and preterm neonates.L46906
The clearance of iopromide decreases with increasing degree of renal impairment and results in delayed opacification of the urinary system. In addition, preexisting renal impairment increases the risk of acute kidney injury. Iopromide can be removed by dialysis.L46906
Long-term animal studies have not been performed with iopromide to evaluate carcinogenic potential or effects on fertility. Iopromide was not genotoxic in a series of studies including the Ames test, an in vitro human lymphocytes analysis of chromosomal aberrations, an in vivo mouse micronucleus assay, and an in vivo mouse dominant lethal assay.L46906
The manifestations of overdosage are life-threatening and affect mainly the pulmonary and cardiovascular systems. Treatment of overdosage is directed toward the support of all vital functions, and prompt institution of symptomatic therapy.L46906
The most common adverse reactions (>1%) are headache, nausea, injection site and infusion site reactions, vasodilatation, vomiting, back pain, urinary urgency, chest pain, pain, dysgeusia, and abnormal vision. Inadvertent intrathecal administration may cause death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema.L46906
Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs.A225366 Although iopromide can cause several serious adverse effects, including cardiac events, thromboembolism, hypersensitivity reaction, and even death if administered intrathecally inadvertently, it is still deemed to have a favorable safety profile, with only 0.7% of patients in a 2 years study experiencing adverse events.A260751 Although the mechanism is unclear, women and outpatients tend to have a higher incidence of adverse events compared to other population groups.A260751
Approved by the FDA in 1995 and Health Canada in 1994 under the brand name ULTRAVIST, iopromide is used in radiological diagnosis, including, but not limited to, intra-arterial digital subtraction angiography (IA-DSA), cerebral and peripheral arteriography, peripheral venography, excretory urography, brain computer tomography (CT), coronary arteriography, left ventriculography, visceral angiography, and orthography.L46906,L46911
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Aldesleukin | The risk of a hypersensitivity reaction to Iopromide is increased when it is combined with Aldesleukin. |
| Metformin | The risk or severity of lactic acidosis can be increased when Iopromide is combined with Metformin. |
| Cyclosporine | Cyclosporine may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Icosapent | Icosapent may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Tenofovir disoproxil | Tenofovir disoproxil may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Indomethacin | Indomethacin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Loracarbef | Loracarbef may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Ketorolac | Ketorolac may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Tenoxicam | Tenoxicam may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Celecoxib | Celecoxib may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Tolmetin | Tolmetin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Foscarnet | Foscarnet may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Rofecoxib | Rofecoxib may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Piroxicam | Piroxicam may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Methotrexate | Methotrexate may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cephalexin | Cephalexin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Valdecoxib | Valdecoxib may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Diclofenac | Diclofenac may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Sulindac | Sulindac may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Amphotericin B | Amphotericin B may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Flurbiprofen | Flurbiprofen may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Pentamidine | Pentamidine may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Etodolac | Etodolac may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Mefenamic acid | Mefenamic acid may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Naproxen | Naproxen may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Phenylbutazone | Phenylbutazone may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Meloxicam | Meloxicam may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Carprofen | Carprofen may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefaclor | Cefaclor may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Diflunisal | Diflunisal may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Tacrolimus | Tacrolimus may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Salicylic acid | Salicylic acid may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Acetylsalicylic acid | Acetylsalicylic acid may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Ketoprofen | Ketoprofen may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Ibuprofen | Ibuprofen may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Atazanavir | Atazanavir may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Colistimethate | Colistimethate may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Olsalazine | Olsalazine may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Lumiracoxib | Lumiracoxib may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefotetan | Cefotetan may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefoxitin | Cefoxitin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Ceftizoxime | Ceftizoxime may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefradine | Cefradine may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Magnesium salicylate | Magnesium salicylate may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Salsalate | Salsalate may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Choline magnesium trisalicylate | Choline magnesium trisalicylate may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefepime | Cefepime may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefacetrile | Cefacetrile may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Ceftibuten | Ceftibuten may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cefpodoxime | Cefpodoxime may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Antrafenine | Antrafenine may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Aminophenazone | Aminophenazone may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Antipyrine | Antipyrine may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Tiaprofenic acid | Tiaprofenic acid may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Lopinavir | Lopinavir may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Etoricoxib | Etoricoxib may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Hydrolyzed Cephalothin | Hydrolyzed Cephalothin may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cephalothin Group | Cephalothin Group may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Oxyphenbutazone | Oxyphenbutazone may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Latamoxef | Latamoxef may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Nimesulide | Nimesulide may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Benoxaprofen | Benoxaprofen may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Metamizole | Metamizole may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Zomepirac | Zomepirac may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Ceftobiprole | Ceftobiprole may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Cimicoxib | Cimicoxib may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Ceftaroline fosamil | Ceftaroline fosamil may decrease the excretion rate of Iopromide which could result in a higher serum level. |