Peringatan Keamanan

Overdose toxicity is mainly due to alkalosis as well as tetany or depressed heart function due to lack of free calcium L790.

Sodium citrate

DB09154

small molecule approved investigational

Deskripsi

Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water,
practically insoluble in alcohol. Like citric acid, it has a sour taste.
From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.

Struktur Molekul 2D

Berat 258.068
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 18-54 min [A19414]
Volume Distribusi 19-39L [A19414].
Klirens (Clearance) Total clearance of 313-1107mL/min [A19414].

Absorpsi

Tmax of 98-130min A19414.

Metabolisme

Citrate is metabolized to bicarbonate in the liver and plays a role as an intermediate in the citric acid cycle A19419 L795.

Rute Eliminasi

Largely eliminated through hepatic metabolism with very little cleared by the kidneys A19414 A19415.

Interaksi Makanan

1 Data
  • 1. Take with or without food. Recommendations vary from product to product - consult individual product monographs for additional information.

Interaksi Obat

808 Data
Apixaban Apixaban may increase the anticoagulant activities of Sodium citrate.
Dabigatran etexilate Dabigatran etexilate may increase the anticoagulant activities of Sodium citrate.
Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Sodium citrate.
Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Sodium citrate is combined with Deferasirox.
Ursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Ursodeoxycholic acid.
Glycochenodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Glycochenodeoxycholic Acid.
Cholic Acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Cholic Acid.
Glycocholic acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Glycocholic acid.
Deoxycholic acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Deoxycholic acid.
Taurocholic acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Taurocholic acid.
Obeticholic acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Obeticholic acid.
Chenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Chenodeoxycholic acid.
Taurochenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Taurochenodeoxycholic acid.
Tauroursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Tauroursodeoxycholic acid.
Bamet-UD2 The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Bamet-UD2.
Dehydrocholic acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Dehydrocholic acid.
Hyodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Sodium citrate is combined with Hyodeoxycholic Acid.
Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Sodium citrate.
Ibrutinib The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Sodium citrate.
Obinutuzumab The risk or severity of bleeding and hemorrhage can be increased when Sodium citrate is combined with Obinutuzumab.
Rivaroxaban Sodium citrate may increase the anticoagulant activities of Rivaroxaban.
Sugammadex The risk or severity of bleeding and hemorrhage can be increased when Sodium citrate is combined with Sugammadex.
Tibolone Tibolone may increase the anticoagulant activities of Sodium citrate.
Tipranavir The risk or severity of bleeding and hemorrhage can be increased when Tipranavir is combined with Sodium citrate.
Urokinase Urokinase may increase the anticoagulant activities of Sodium citrate.
Vitamin E Vitamin E may increase the anticoagulant activities of Sodium citrate.
Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Sodium citrate.
Ginkgo biloba Ginkgo biloba may increase the anticoagulant activities of Sodium citrate.
Ifosfamide The risk or severity of bleeding can be increased when Ifosfamide is combined with Sodium citrate.
Quinine The therapeutic efficacy of Sodium citrate can be increased when used in combination with Quinine.
Quinidine The therapeutic efficacy of Sodium citrate can be increased when used in combination with Quinidine.
Tamoxifen The risk or severity of bleeding can be increased when Tamoxifen is combined with Sodium citrate.
Toremifene The risk or severity of bleeding can be increased when Toremifene is combined with Sodium citrate.
Pentoxifylline The therapeutic efficacy of Sodium citrate can be increased when used in combination with Pentoxifylline.
Aluminum hydroxide Sodium citrate can cause an increase in the absorption of Aluminum hydroxide resulting in an increased serum concentration and potentially a worsening of adverse effects.
Pentosan polysulfate Pentosan polysulfate may increase the anticoagulant activities of Sodium citrate.
Levocarnitine The therapeutic efficacy of Sodium citrate can be increased when used in combination with Levocarnitine.
Diethylstilbestrol Diethylstilbestrol may decrease the anticoagulant activities of Sodium citrate.
Chlorotrianisene Chlorotrianisene may decrease the anticoagulant activities of Sodium citrate.
Conjugated estrogens Conjugated estrogens may decrease the anticoagulant activities of Sodium citrate.
Mestranol The risk or severity of adverse effects can be increased when Mestranol is combined with Sodium citrate.
Estrone sulfate Estrone sulfate may decrease the anticoagulant activities of Sodium citrate.
Quinestrol Quinestrol may decrease the anticoagulant activities of Sodium citrate.
Hexestrol Hexestrol may decrease the anticoagulant activities of Sodium citrate.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Sodium citrate.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Sodium citrate.
Polyestradiol phosphate Polyestradiol phosphate may decrease the anticoagulant activities of Sodium citrate.
Esterified estrogens Esterified estrogens may decrease the anticoagulant activities of Sodium citrate.
Zeranol Zeranol may decrease the anticoagulant activities of Sodium citrate.
Equol Equol may decrease the anticoagulant activities of Sodium citrate.
Methallenestril Methallenestril may decrease the anticoagulant activities of Sodium citrate.
Epimestrol Epimestrol may decrease the anticoagulant activities of Sodium citrate.
Moxestrol Moxestrol may decrease the anticoagulant activities of Sodium citrate.
Estradiol acetate Estradiol acetate may decrease the anticoagulant activities of Sodium citrate.
Estradiol benzoate Estradiol benzoate may decrease the anticoagulant activities of Sodium citrate.
Estradiol cypionate Estradiol cypionate may decrease the anticoagulant activities of Sodium citrate.
Estradiol valerate Estradiol valerate may decrease the anticoagulant activities of Sodium citrate.
Biochanin A Biochanin A may decrease the anticoagulant activities of Sodium citrate.
Formononetin Formononetin may decrease the anticoagulant activities of Sodium citrate.
Estriol Estriol may decrease the anticoagulant activities of Sodium citrate.
Limaprost The risk or severity of adverse effects can be increased when Limaprost is combined with Sodium citrate.
Icosapent The risk or severity of bleeding and hemorrhage can be increased when Icosapent is combined with Sodium citrate.
Mesalazine The risk or severity of bleeding can be increased when Mesalazine is combined with Sodium citrate.
Indomethacin The risk or severity of bleeding and hemorrhage can be increased when Indomethacin is combined with Sodium citrate.
Nabumetone The risk or severity of bleeding and hemorrhage can be increased when Nabumetone is combined with Sodium citrate.
Ketorolac The risk or severity of bleeding and hemorrhage can be increased when Ketorolac is combined with Sodium citrate.
Tenoxicam The risk or severity of bleeding and hemorrhage can be increased when Tenoxicam is combined with Sodium citrate.
Celecoxib The risk or severity of bleeding and hemorrhage can be increased when Celecoxib is combined with Sodium citrate.
Tolmetin The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Sodium citrate.
Rofecoxib The risk or severity of bleeding and hemorrhage can be increased when Rofecoxib is combined with Sodium citrate.
Piroxicam The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Sodium citrate.
Fenoprofen The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Sodium citrate.
Valdecoxib The risk or severity of bleeding and hemorrhage can be increased when Valdecoxib is combined with Sodium citrate.
Diclofenac The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Sodium citrate.
Sulindac The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Sodium citrate.
Flurbiprofen The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen is combined with Sodium citrate.
Etodolac The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with Sodium citrate.
Mefenamic acid The risk or severity of bleeding and hemorrhage can be increased when Mefenamic acid is combined with Sodium citrate.
Naproxen The risk or severity of bleeding and hemorrhage can be increased when Naproxen is combined with Sodium citrate.
Sulfasalazine The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with Sodium citrate.
Phenylbutazone The risk or severity of bleeding and hemorrhage can be increased when Phenylbutazone is combined with Sodium citrate.
Meloxicam The risk or severity of bleeding and hemorrhage can be increased when Meloxicam is combined with Sodium citrate.
Carprofen The risk or severity of bleeding and hemorrhage can be increased when Carprofen is combined with Sodium citrate.
Diflunisal The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Sodium citrate.
Salicylic acid The risk or severity of bleeding and hemorrhage can be increased when Salicylic acid is combined with Sodium citrate.
Meclofenamic acid The risk or severity of bleeding and hemorrhage can be increased when Meclofenamic acid is combined with Sodium citrate.
Oxaprozin The risk or severity of bleeding and hemorrhage can be increased when Oxaprozin is combined with Sodium citrate.
Ketoprofen The risk or severity of bleeding and hemorrhage can be increased when Ketoprofen is combined with Sodium citrate.
Balsalazide The risk or severity of bleeding and hemorrhage can be increased when Balsalazide is combined with Sodium citrate.
Olsalazine The risk or severity of bleeding can be increased when Olsalazine is combined with Sodium citrate.
Lumiracoxib The risk or severity of bleeding and hemorrhage can be increased when Lumiracoxib is combined with Sodium citrate.
Magnesium salicylate The risk or severity of bleeding and hemorrhage can be increased when Magnesium salicylate is combined with Sodium citrate.
Salsalate The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Sodium citrate.
Choline magnesium trisalicylate The risk or severity of bleeding and hemorrhage can be increased when Choline magnesium trisalicylate is combined with Sodium citrate.
Antrafenine The risk or severity of bleeding and hemorrhage can be increased when Antrafenine is combined with Sodium citrate.
Aminophenazone The risk or severity of bleeding and hemorrhage can be increased when Aminophenazone is combined with Sodium citrate.
Antipyrine The risk or severity of bleeding and hemorrhage can be increased when Antipyrine is combined with Sodium citrate.
Tiaprofenic acid The risk or severity of bleeding and hemorrhage can be increased when Tiaprofenic acid is combined with Sodium citrate.
Etoricoxib The risk or severity of bleeding and hemorrhage can be increased when Etoricoxib is combined with Sodium citrate.
Taxifolin The risk or severity of bleeding and hemorrhage can be increased when Taxifolin is combined with Sodium citrate.

Target Protein

Carbonic anhydrase 4 CA4

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17883701
    Mann KG, Whelihan MF, Butenas S, Orfeo T: Citrate anticoagulation and the dynamics of thrombin generation. J Thromb Haemost. 2007 Oct;5(10):2055-61.
  • PMID: 25535411
    Palta S, Saroa R, Palta A: Overview of the coagulation system. Indian J Anaesth. 2014 Sep;58(5):515-23. doi: 10.4103/0019-5049.144643.
  • PMID: 14530750
    Kramer L, Bauer E, Joukhadar C, Strobl W, Gendo A, Madl C, Gangl A: Citrate pharmacokinetics and metabolism in cirrhotic and noncirrhotic critically ill patients. Crit Care Med. 2003 Oct;31(10):2450-5.
  • PMID: 23824037
    Zheng Y, Xu Z, Zhu Q, Liu J, Qian J, You H, Gu Y, Hao C, Jiao Z, Ding F: Citrate Pharmacokinetics in Critically Ill Patients with Acute Kidney Injury. PLoS One. 2013 Jun 18;8(6):e65992. doi: 10.1371/journal.pone.0065992. Print 2013.
  • PMID: 26131288
    Li K, Xu Y: Citrate metabolism in blood transfusions and its relationship due to metabolic alkalosis and respiratory acidosis. Int J Clin Exp Med. 2015 Apr 15;8(4):6578-84. eCollection 2015.

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