Peringatan Keamanan

The rare inadvertent intravascular administration or rapid intravascular absorption of hypertonic sodium chloride can cause a shift of tissue fluids into the vascular bed, resulting in hypervolemia, electrolyte disturbances, circulatory failure, pulmonary embolism, or augmented hypertension.

Sodium chloride

DB09153

small molecule approved vet_approved

Deskripsi

Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride is the primary salt in seawater and in the extracellular fluid of many multicellular organisms. It is listed on the World Health Organization Model List of Essential Medicines.

Struktur Molekul 2D

Berat 58.443
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 17 minutes
Volume Distribusi The volume of distribution is 0.64 L/kg.
Klirens (Clearance) -

Absorpsi

Absorption of sodium in the small intestine plays an important role in the absorption of chloride, amino acids, glucose, and water. Chloride, in the form of hydrochloric acid (HCl), is also an important component of gastric juice, which aids the digestion and absorption of many nutrients.

Metabolisme

The salt that is taken in to gastro intestinal tract remains for the most part unabsorbed as the liquid contents pass through the stomach and small bowel. On reaching the colon this salt, together with the water is taken in to the blood. As excesses are absorbed the kidney is constantly excreting sodium chloride, so that the chloride level in the blood and tissues remains fairly constant.Further more, if the chloride intake ceases, the kidney ceases to excrete chlorides. Body maintains an equilibrium retaining the 300gm of salt dissolved in the blood and fluid elements of the tissue dissociated into sodium ions and chloride ions.

Rute Eliminasi

Substantially excreted by the kidneys.

Interaksi Obat

4 Data
Lithium citrate Sodium chloride may increase the excretion rate of Lithium citrate which could result in a lower serum level and potentially a reduction in efficacy.
Lithium carbonate Sodium chloride may increase the excretion rate of Lithium carbonate which could result in a lower serum level and potentially a reduction in efficacy.
Lithium hydroxide Sodium chloride may increase the excretion rate of Lithium hydroxide which could result in a lower serum level and potentially a reduction in efficacy.
Tolvaptan The risk or severity of adverse effects can be increased when Sodium chloride is combined with Tolvaptan.

Referensi & Sumber

Contoh Produk & Brand

Produk: 1854 • International brands: 0
Produk
  • (20 Mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (20 Mmol/l) Potassium Chloride In 5% Dextrose and 0.9% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (20mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (20mmol/l) Potassium Chloride In 5% Dextrose and 0.2% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (20mmol/l) Potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (40 Mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP
    Liquid • - • Intravenous • Canada • Approved
  • (40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (40mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
Menampilkan 8 dari 1854 produk.

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